scholarly journals Ambient particulate matter enhances the pulmonary allergic immune response to house dust mite in a BALB/c mouse model by augmenting Th2- and Th17-immune responses

2018 ◽  
Vol 6 (18) ◽  
pp. e13827 ◽  
Author(s):  
Alejandro R. Castañeda ◽  
Christoph F. A. Vogel ◽  
Keith J. Bein ◽  
Heather K. Hughes ◽  
Suzette Smiley-Jewell ◽  
...  
Keyword(s):  
Immune Response ◽  
Particulate Matter ◽  
Mouse Model ◽  
Immune Responses ◽  
House Dust ◽  
House Dust Mite ◽  
Ambient Particulate Matter ◽  
Dust Mite ◽  
Allergic Immune Response

scholarly journals G Protein-Coupled Receptor Kinase 2 (GRK2) Regulates T Cell Response in a Murine Model of House Dust Mite-Induced Asthma

2021 ◽  
Vol 2 ◽  
Author(s):  
Ananth K. Kammala ◽  
Canchai Yang ◽  
Reynold A. Panettieri ◽  
Rupali Das ◽  
Hariharan Subramanian
Keyword(s):  
T Cell ◽  
Mouse Model ◽  
G Protein ◽  
House Dust ◽  
House Dust Mite ◽  
T Cell Response ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Dust Mite ◽  
G Protein Coupled

G protein-coupled receptor kinase 2 (GRK2) is an adapter protein that modulates G protein-coupled receptor (GPCR) signaling. It also regulates the functions and activity of other intracellular proteins in many cell types. Accordingly, GRK2 is thought to contribute to disease progression by a variety of mechanisms related to its multifunctional roles. Indeed, GRK2 levels are enhanced in patient samples as well as in preclinical models of several diseases. We have previously shown that GRK2 regulates mast cell functions, and thereby contributes to exacerbated inflammation during allergic reactions. In the current study, we observed that GRK2 levels are enhanced in the lungs of human asthma patients and in mice sensitized to house dust mite extract (HDME) allergen. Consistent with these findings, interleukin (IL)-4 and IL-13 levels were reduced in the lungs of GRK2+/− mice in a HMDE mouse model of asthma. Because Th2 cells are the major source of these cytokines during asthma, we determined the role of GRK2 in regulating T cell-specific responses in our HMDE mouse model. We observed a significant reduction of airway hyperresponsiveness (AHR), lung eosinophil and lymphocyte counts, serum IgE, Th2 cytokines (IL-4 and IL-13), goblet cell hyperplasia and mucus production in mice that had reduced GRK2 expression specifically in T cells. Collectively, our studies reveal an important role for GRK2 in regulating T cell response during asthma pathogenesis and further elucidation of the mechanisms through which GRK2 modulates airway inflammation will lead to the development of new therapeutic strategies for asthma.

scholarly journals Semaphorin 3E Inhibits House Dust Mite–Induced Angiogenesis in a Mouse Model of Allergic Asthma

2019 ◽  
Vol 189 (4) ◽  
pp. 762-772 ◽  
Author(s):  
Nazanin Tatari ◽  
Hesam Movassagh ◽  
Lianyu Shan ◽  
Latifa Koussih ◽  
Abdelilah S. Gounni
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite

A comparison of the allergic responses induced by Penicillium chrysogenum and house dust mite extracts in a mouse model

Indoor Air ◽  
2010 ◽  
Vol 20 (5) ◽  
pp. 380-391 ◽  
Author(s):  
M. D. W. Ward ◽  
Y. J. Chung ◽  
L. B. Copeland ◽  
D. L. Doerfler
Keyword(s):  
Mouse Model ◽  
House Dust ◽  
House Dust Mite ◽  
Penicillium Chrysogenum ◽  
Dust Mite

Protective effect of Streptococcus thermophilus CCFM218 against house dust mite allergy in a mouse model

Food Control ◽  
2015 ◽  
Vol 50 ◽  
pp. 283-290 ◽  
Author(s):  
Chunqing Ai ◽  
Qiuxiang Zhang ◽  
Chengcheng Ren ◽  
Gang Wang ◽  
Xiaoming Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
House Dust ◽  
House Dust Mite ◽  
Streptococcus Thermophilus ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite

The Influence of Chitin on the Immune Response to the House Dust Mite Allergen Blo t 12

2013 ◽  
Vol 163 (2) ◽  
pp. 119-129 ◽  
Author(s):  
Josefina Zakzuk ◽  
Inés Benedetti ◽  
Enrique Fernández-Caldas ◽  
Luis Caraballo
Keyword(s):  
Immune Response ◽  
House Dust ◽  
House Dust Mite ◽  
Mite Allergen ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Dust Mite Allergen
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