scholarly journals Metabolic effects of Tofogliflozin are efficiently enhanced with appropriate dietary carbohydrate ratio and are distinct from carbohydrate restriction

2018 ◽  
Vol 6 (5) ◽  
pp. e13642 ◽  
Author(s):  
Shiori Ito ◽  
Toshio Hosaka ◽  
Wataru Yano ◽  
Takahiro Itou ◽  
Misako Yasumura ◽  
...  
Keyword(s):  
Metabolic Effects ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate

Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction

2005 ◽  
Vol 289 (2) ◽  
pp. E306-E312 ◽  
Author(s):  
Matthew P. Harber ◽  
Simon Schenk ◽  
Ariel L. Barkan ◽  
Jeffrey F. Horowitz
Keyword(s):  
Glucose Uptake ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Carbohydrate Oxidation ◽  
Metabolic Effects ◽  
Glucose Disposal ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate ◽  
Endogenous Glucose ◽  
Glucose Availability

Dietary carbohydrate restriction (CR) presents a challenge to glucose homeostasis. Despite the popularity of CR diets, little is known regarding the metabolic effects of CR. The purpose of this study was to examine changes in whole body carbohydrate oxidation, glucose availability, endogenous glucose production, and peripheral glucose uptake after dietary CR, without the confounding influence of a negative energy balance. Postabsorptive rates of glucose appearance in plasma (Ra; i.e., endogenous glucose production) and disappearance from plasma (Rd; i.e., glucose uptake) were measured using isotope dilution methods after a conventional diet [60% carbohydrate (CHO), 30% fat, and 10% protein; kcals = 1.3 × resting energy expenditure (REE)] and after 2 days and 7 days of CR (5% CHO, 60% fat, and 35% protein; kcals = 1.3 × REE) in eight subjects (means ± SE; 29 ± 4 yr; BMI 24 ± 1 kg/m2) during a 9-day hospital visit. Postabsorptive plasma glucose concentration was reduced ( P = 0.01) after 2 days but returned to prediet levels the next day and remained at euglycemic levels throughout the diet (5.1 ± 0.2, 4.3 ± 0.3, and 4.8 ± 0.4 mmol/l for prediet, 2 days and 7 days, respectively). Glucose Ra and glucose Rd were reduced to below prediet levels (9.8 ± 0.6 μmol·kg−1·min−1) after 2 days of CR (7.9 ± 0.3 μmol·kg−1·min−1) and remained suppressed after 7 days (8.3 ± 0.4 μmol·kg−1·min−1; both P < 0.001). A greater suppression in carbohydrate oxidation, compared with the reduction in glucose Rd, led to an increased (all P ≤ 0.05) rate of nonoxidative glucose disposal at 7 days (5.2 ± 0.5 μmol·kg−1·min−1), compared with 2 days (2.7 ± 0.5 μmol·kg−1·min−1) and prediet (1.6 ± 0.8 μmol·kg−1·min−1). In response to eucaloric CR, a marked increase in nonoxidative glucose disposal may help maintain systemic glucose availability.

scholarly journals Regulation of hepatic lipids and antioxidants by dietary carbohydrate restriction and cholesterol in guinea pigs

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Richard S Bruno ◽  
Moises Torres‐Gonzalez ◽  
Steven F Yeung ◽  
Steven R Davis ◽  
Jeff S Volek ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate ◽  
Hepatic Lipids

Corrigendum to “Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base” [Nutrition 31 (2015) 1-13]

Nutrition ◽  
2019 ◽  
Vol 62 ◽  
pp. 213 ◽  
Author(s):  
Richard D. Feinman ◽  
Wendy K. Pogozelski ◽  
Arne Astrup ◽  
Richard K. Bernstein ◽  
Eugene J. Fine ◽  
...  
Keyword(s):  
Critical Review ◽  
Diabetes Management ◽  
Evidence Base ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate

scholarly journals Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss

JCI Insight ◽  
2019 ◽  
Vol 4 (12) ◽  
Author(s):  
Parker N. Hyde ◽  
Teryn N. Sapper ◽  
Christopher D. Crabtree ◽  
Richard A. LaFountain ◽  
Madison L. Bowling ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate

scholarly journals Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?

2014 ◽  
Vol 2 (S1) ◽  
Author(s):  
Eugene J Fine ◽  
C Segal-Isaacson ◽  
Silvia Herzkopf ◽  
Joseph Sparano ◽  
Maria Romano ◽  
...  
Keyword(s):  
Carbohydrate Restriction ◽  
Dietary Carbohydrate ◽  
Igf Signaling

scholarly journals Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

2006 ◽  
Vol 3 (1) ◽  
Author(s):  
Gualberto Ruaño ◽  
Andreas Windemuth ◽  
Mohan Kocherla ◽  
Theodore Holford ◽  
Maria Luz Fernandez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate

Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilation

Metabolism ◽  
2009 ◽  
Vol 58 (12) ◽  
pp. 1769-1777 ◽  
Author(s):  
Jeff S. Volek ◽  
Kevin D. Ballard ◽  
Ricardo Silvestre ◽  
Daniel A. Judelson ◽  
Erin E. Quann ◽  
...  
Keyword(s):  
Flow Mediated Dilation ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate ◽  
Low Fat ◽  
Low Fat Diet

Interim analysis of a prospective randomized trial of dietary carbohydrate restriction for men with a rising PSA after failed primary treatment: Carbohydrate and Prostate Study 2 (CAPS2).

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 382-382
Author(s):  
Stephen J. Freedland ◽  
Jenifer Allen ◽  
Andrew J. Armstrong ◽  
Judd W. Moul ◽  
Howard M. Sandler ◽  
...  
Keyword(s):  
Weight Loss ◽  
Interim Analysis ◽  
Dietary Intervention ◽  
Local Treatment ◽  
Carbohydrate Restriction ◽  
Dietary Carbohydrate ◽  
Carbohydrate Diet ◽  
Curative Intent ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

382 Background: Nearly one third of men treated with curative intent for localized prostate cancer (PC) will develop a rising PSA. The rate of PSA rise (PSA doubling time aka PSASDT) is a predictor metastases and PC death. In laboratory mice, an extreme low carbohydrate diet slows PC growth. We tested whether this diet could slow PSADT in men with recurrent PC. Methods: We are conducting a 6-month multi-center randomized phase II trial of dietary carbohydrate restriction vs. no diet intervention control. Men had to have a BMI ≥24 kg/m2, received radical prostatectomy or definitive local radiation for PC, had a PSA 0.4-20.0 ng/ml (3-20 if prior radiation therapy) within the past 3 months, and current PSADT 3-36 months. The intervention arm was instructed to eat < 20 grams/carbs/day with no other limits. The control arm was told to make no diet. In this interim analysis, we present the efficacy of the dietary intervention with regards to weight loss. Arms were compared using rank-sum. Total anticipated enrollment is 60. The primary outcome is differences in PSADT between arms. Secondary outcomes include weight loss, and dietary make-up. Results: To date, 28 patients (14 in each study arm) have completed the study. Characteristics were well-balanced at baseline. At the 6-month dietary assessment, calorie consumption was similar between the two study arms (p = 0.090) among the 16 patients (7 low-carb, 9 control) with diet information. Subjects in the low-carb arm ate fewer carbs (29 vs. 188 g, p = 0.008) and more protein (125 vs. 73 g, p = 0.044) but similar amounts of fat (75 vs. 67 g, p = 0.672) vs. subjects in the control arm. Six months on the low carb diet resulted in greater weight loss (median: 31.7 vs. 0.8 lbs, p < 0.001), lower BMI (24.4 vs. 29.6 kg/m2, p < 0.001), and smaller waist circumference (95.7 vs. 108.9 cm, p = 0.002). Conclusions: In this interim analysis of an on-going dietary study for men with a rising PSA after definitive local treatment, an extreme low carbohydrate diet results in dramatic weight loss in 6 months. Whether this weight loss slows PC growth is an on-going question. Clinical trial information: NCT01763944.

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