scholarly journals Intimal hyperplasia induced by vascular intervention causes lipoprotein retention and accelerated atherosclerosis

2017 ◽  
Vol 5 (14) ◽  
pp. e13334 ◽  
Author(s):  
Siavash Kijani ◽  
Ana Maria Vázquez ◽  
Malin Levin ◽  
Jan Borén ◽  
Per Fogelstrand
Keyword(s):  
Intimal Hyperplasia ◽  
Vascular Intervention ◽  
Accelerated Atherosclerosis ◽  
Lipoprotein Retention

Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention

2019 ◽  
Vol 68 ◽  
pp. 34-44
Author(s):  
Michael R Buckley ◽  
Paul D Terry ◽  
Stacy S Kirkpatrick ◽  
Joshua D Arnold ◽  
Michael M McNally ◽  
...  
Keyword(s):  
Fish Oil ◽  
Intimal Hyperplasia ◽  
Dietary Supplementation ◽  
Herbal Extracts ◽  
Vascular Intervention

Effect of Clopidogrel on Platelet Aggregation and Intimal Hyperplasia following Carotid Endarterectomy in the Rat

Vascular ◽  
2005 ◽  
Vol 13 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Shelly L. Bledsoe ◽  
Aliza T. Brown ◽  
Joseph A. Davis ◽  
Hongjiang Chen ◽  
John F. Eidt ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Carotid Endarterectomy ◽  
Intimal Hyperplasia ◽  
Antiplatelet Agent ◽  
Plasma Homocysteine ◽  
Significant Morbidity ◽  
Sprague Dawley ◽  
Platelet Activity ◽  
Vascular Intervention ◽  
Sprague Dawley Rats

Intimal hyperplasia results in significant morbidity and mortality following vascular intervention. Both platelets and elevated homocysteine have been implicated in the development of intimal hyperplasia. We previously demonstrated that a locally applied antiplatelet agent decreases the development of intimal hyperplasia. We were therefore interested in a systemic antiplatelet agent, clopidogrel. We hypothesized that clopidogrel would decrease platelet aggregation and activity and intimal hyperplasia. Male Sprague-Dawley rats underwent carotid endarterectomy (CEA) and treatment with either placebo or varying regimens of clopidogrel, including chronic, pre-CEA bolus, chronic plus pre-CEA bolus, and chronic plus post-CEA bolus; a homocystine diet was used to elevate both plasma homocysteine and the degree of intimal hyperplasia. Platelet aggregation, platelet activity, and intimal hyperplasia were then assessed. Platelet aggregation was not decreased with chronic clopidogrel; however, it was decreased with pre-CEA bolus clopidogrel. Similarly, platelet activity was not inhibited by chronic clopidogrel but was inhibited by pre-CEA and chronic plus pre-CEA bolus clopidogrel. Neither chronic, pre-CEA bolus, chronic plus pre-CEA bolus, nor chronic plus post-CEA bolus clopidogrel resulted in a decrease in intimal hyperplasia. Although pre-CEA bolus clopidogrel resulted in a decrease in both platelet aggregation and activity, it was unable to decrease the development of intimal hyperplasia at any dose. Additional factors must therefore contribute to the pathologic development of intimal hyperplasia.

Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention?

2007 ◽  
Vol 114 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Andreas C. Gidlöf ◽  
Pauline Ocaya ◽  
Olesya Krivospitskaya ◽  
Allan Sirsjö
Keyword(s):  
Vitamin A ◽  
Intimal Hyperplasia ◽  
Clinical Problem ◽  
Coronary Intervention ◽  
Matrix Composition ◽  
Transcriptional Level ◽  
Term Outcome ◽  
Vascular Intervention ◽  
Long Term Outcome ◽  
Endovascular Interventions

The re-establishment of adequate blood flow in a vessel with a reduced lumen due to an atherosclerotic plaque by percutaneous vascular intervention is a well established procedure. However, the long-term outcome of such interventions is negatively influenced by the development of intimal hyperplasia/restenosis. Although extensively researched, this still represents a significant clinical problem. Retinoids, i.e. natural and synthetic derivates of vitamin A, represent a potential therapeutic compound, since they have been shown to influence the vast majority of processes that ultimately lead to reocclusion of the injured vessel. Retinoids exert their effects at the transcriptional level through their nuclear receptors. Targeting multiple processes, i.e. proliferation, migration, extracellular matrix composition and cell differentiation, as well as coagulation/fibrinolysis, should increase their future role in the prevention of restenosis. The purpose of this review is to summarize the diverse effects of retinoids on pathobiological and biological processes activated at sites of vascular injury with particular emphasis on intimal hyperplasia/restenosis after endovascular interventions.

Platelet adhesion on endothelium early after vein grafting mediates leukocyte recruitment and intimal hyperplasia in a murine model

2015 ◽  
Vol 113 (04) ◽  
pp. 813-825 ◽  
Author(s):  
Chi-Nan Tseng ◽  
Ya-Ting Chang ◽  
Mariette Lengquist ◽  
Malin Kronqvist ◽  
Ulf Hedin ◽  
...  
Keyword(s):  
Early Intervention ◽  
Intimal Hyperplasia ◽  
Platelet Adhesion ◽  
Leukocyte Adhesion ◽  
Vena Cava ◽  
Specific Treatment ◽  
Leukocyte Recruitment ◽  
Blocking Antibody ◽  
Accelerated Atherosclerosis ◽  
Vein Grafts

SummaryIntimal hyperplasia (IH) is the substrate for accelerated atherosclerosis and limited patency of vein grafts. However, there is still no specific treatment targeting IH following graft surgery. In this study, we used a mouse model of vein grafting to investigate the potential for early intervention with platelet function for later development of graft IH. We transferred the inferior vena cava (IVC) from donor C57BL/6 mice to the carotid artery in recipients using a cuff technique. We found extensive endothelial injury and platelet adhesion one hour following grafting. Adhesion of leukocytes was distinct in areas of platelet adhesion. Platelet and leukocyte adhesion was strongly reduced in mice receiving a function-blocking antibody against the integrin αIIbβ3. This was followed by a reduction of IH one month following grafting. Depletion of platelets using antiserum also reduced IH at later time points. These findings indicate platelets as pivotal to leukocyte recruitment to the wall of vein grafts. In conclusion, the data also highlight early intervention of platelets and inflammation as potential treatment for later formation of IH and accelerated atherosclerosis following bypass surgery.

Reduction in Mechanical Wall Strain Precedes Intimal Hyperplasia Formation in a Murine Model of Arterial Occlusive Disease

2013 ◽  
Author(s):  
John T. Favreau ◽  
Chengwei Liu ◽  
Peng Yu ◽  
Christine Mauro ◽  
Ming Tao ◽  
...  
Keyword(s):  
Intimal Hyperplasia ◽  
Endovascular Procedures ◽  
The United States ◽  
Peripheral Artery ◽  
Vascular Intervention ◽  
Need For Treatment ◽  
Vessel Lumen ◽  
Post Procedure ◽  
Underlying Causes ◽  
Artery Disease

Coronary artery disease and peripheral artery disease remain a significant source of mortality and vascular morbidity in the United States; both affecting over 14 million Americans.[1] Although a number of both open and endovascular procedures are available for treating occlusive lesions, post-procedure intimal hyperplasia (IH) and pathological wall adaptation in treated arteries cause further need for treatment. As on average 50% of patients receiving these treatments must receive further vascular intervention to prevent the continued expansion of IH into the vessel lumen, there is a need to improve our understanding of the underlying causes of IH formation.[2]

scholarly journals 867-5 Rosiglitazone modulates angiogenic progenitor cell differentiation and attenuates intimal hyperplasia after vascular intervention

2004 ◽  
Vol 43 (5) ◽  
pp. A527 ◽  
Author(s):  
Chao-Hung Wang ◽  
Shu-Hong Li ◽  
Richard D Weisel ◽  
Paul E Szmitko ◽  
Cristina Fayet ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Intimal Hyperplasia ◽  
Progenitor Cell ◽  
Vascular Intervention

Multidisciplinary team decision is rare and decreasing in percutaneous vascular interventions despite positive impact on in-hospital outcomes

VASA ◽  
2019 ◽  
Vol 48 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Christian-Alexander Behrendt ◽  
Tilo Kölbel ◽  
Thea Schwaneberg ◽  
Holger Diener ◽  
Ralf Hohnhold ◽  
...  
Keyword(s):  
Multidisciplinary Team ◽  
Positive Impact ◽  
Cross Sectional Study ◽  
Invasive Treatment ◽  
Cross Sectional ◽  
Hospital Outcomes ◽  
Vascular Intervention ◽  
Medical Specialties ◽  
Team Decision ◽  
The Impact

Abstract. Background: Worldwide prevalence of peripheral artery disease (PAD) is increasing and peripheral vascular intervention (PVI) has become the primary invasive treatment. There is evidence that multidisciplinary team decision-making (MTD) has an impact on in-hospital outcomes. This study aims to depict practice patterns and time changes regarding MTD of different medical specialties. Methods: This is a retrospective cross-sectional study design. 20,748 invasive, percutaneous PVI of PAD conducted in the metropolitan area of Hamburg (Germany) were consecutively collected between January 2004 and December 2014. Results: MTD prior to PVI was associated with lower odds of early unsuccessful termination of the procedures (Odds Ratio 0.662, p < 0.001). The proportion of MTD decreased over the study period (30.9 % until 2009 vs. 16.6 % from 2010, p < 0.001) while rates of critical limb-threatening ischemia (34.5 % vs. 42.1 %), patients´ age (70 vs. 72 years), PVI below-the-knee (BTK) (13.2 % vs. 22.4 %), and rates of severe TASC C/D lesions BTK (43.2 % vs. 54.2 %) increased (all p < 0.001). Utilization of MTD was different between medical specialties with lowest frequency in procedures performed by internists when compared to other medical specialties (7.1 % vs. 25.7 %, p < 0.001). Conclusions: MTD prior to PVI is associated with technical success of the procedure. Nonetheless, rates of MTD prior to PVI are decreasing during the study period. Future studies should address the impact of multidisciplinary vascular teams on long-term outcomes.

Presentation with Personality changes and Tinnitus to a Vascular Intervention: Rare case of Carotid Body Paraganglioma

2018 ◽  
pp. e000109
Author(s):  
Ahsan Zil-E-Ali ◽  
Zubair Ahmed ◽  
Amber Ehsan Faquih ◽  
Muhammad Ishaq ◽  
Muhammad Aadil
Keyword(s):  
Case Report ◽  
Carotid Body ◽  
Neuroendocrine Neoplasms ◽  
Vascular Surgeon ◽  
Vascular Intervention ◽  
Presenting Symptoms ◽  
Personality Changes ◽  
Tender Mass ◽  
Carotid Body Tumors ◽  
General Physical

Background: Carotid body paragangliomas are rare neuroendocrine neoplasms of chromaffin negative glomus cells. This case report explains an atypical case with unusual presentation and treatment. Case Report: A healthy smoker technician by profession was brought to the emergency room (ER) with coprolalia. The general physical exam did not reveal any information. His history revealed unilateral tinnitus and odynophagia leading to a consultation by the neurologist with head imaging. Acoustic neuroma was ruled out and the caregiver was asked to elaborate the events mentioned in the history and a psychiatric examination was done. The personality changes were evaluated by the psychiatrist that showed overlapping of delirium and depression. The patient was further examined by a vascular surgeon. After careful revisiting of the history, examination and indication of tender mass in the neck by the patient's vascular surgeon, the diagnosis of carotid body paraganglioma was made which was followed by surgical resection for treatment. Conclusion: Carotid Body Paragangliomas are very vascular structures and their manipulation in a surgery setting requires expertise. This case presented with personality changes and tinnitus, a very less likely event to occur in a carotid body tumor. The present care report, thus adds on to the literature of carotid body tumors and its presenting symptoms.

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