scholarly journals Glicentin-related pancreatic polypeptide inhibits glucose-stimulated insulin secretion from the isolated pancreas of adult male rats

2015 ◽  
Vol 3 (12) ◽  
pp. e12638 ◽  
Author(s):  
Lynda Whiting ◽  
Kevin W. Stewart ◽  
Deborah L. Hay ◽  
Paul W. Harris ◽  
Yee S. Choong ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Adult Male ◽  
Pancreatic Polypeptide ◽  
Male Rats ◽  
Isolated Pancreas ◽  
Glucose Stimulated Insulin Secretion

Insulin secretion in Walker 256 tumor cachexia

1990 ◽  
Vol 258 (6) ◽  
pp. E1033-E1036 ◽  
Author(s):  
L. C. Fernandes ◽  
U. F. Machado ◽  
C. R. Nogueira ◽  
A. R. Carpinelli ◽  
R. Curi
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Adult Male ◽  
Male Rats ◽  
Control Group ◽  
Tumor Bearing ◽  
Isolated Islets Of Langerhans ◽  
Outflow Rate ◽  
Walker 256 ◽  
Walker 256 Tumor

The effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.

Nitrite increases glucose-stimulated insulin secretion and islet insulin content in obese type 2 diabetic male rats

Nitric Oxide ◽  
2017 ◽  
Vol 64 ◽  
pp. 39-51 ◽  
Author(s):  
Sevda Gheibi ◽  
Fatemeh Bakhtiarzadeh ◽  
Sajad Jeddi ◽  
Khadijeh Farrokhfall ◽  
Homeira Zardooz ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Male Rats ◽  
Insulin Content ◽  
Glucose Stimulated Insulin Secretion ◽  
Type 2 Diabetic

scholarly journals Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic α-cell

2014 ◽  
Vol 306 (11) ◽  
pp. E1257-E1263 ◽  
Author(s):  
Alison S. Salvatori ◽  
Mollisa M. Elrick ◽  
Willis K. Samson ◽  
John A. Corbett ◽  
Gina L. C. Yosten
Keyword(s):  
Insulin Secretion ◽  
Cell Line ◽  
Insulin Release ◽  
Glucose Homeostasis ◽  
Direct Action ◽  
Peptide Hormone ◽  
Male Rats ◽  
Glucose Disposal ◽  
Glucose Stimulated Insulin Secretion

Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing α-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the α-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized α-cell line αTC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the β-cell line INS 832/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the α-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between α-cells and β-cells in the endocrine pancreas, leading to attenuation in insulin secretion.

Effect of early life stress on pancreatic isolated islets’ insulin secretion in young adult male rats subjected to chronic stress

Endocrine ◽  
2014 ◽  
Vol 48 (2) ◽  
pp. 493-503 ◽  
Author(s):  
Forouzan Sadeghimahalli ◽  
Roxana Karbaschi ◽  
Homeira Zardooz ◽  
Fariba Khodagholi ◽  
Fatemeh Rostamkhani
Keyword(s):  
Insulin Secretion ◽  
Young Adult ◽  
Chronic Stress ◽  
Adult Male ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Isolated Islets ◽  
Male Rats ◽  
Young Adult Male

Age and gender effects on insulin secretion and glucose sensitivity of the endocrine pancreas

1992 ◽  
Vol 262 (4) ◽  
pp. R671-R676 ◽  
Author(s):  
R. C. Ruhe ◽  
D. L. Curry ◽  
S. Herrmann ◽  
R. B. McDonald
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Glucose Oxidation ◽  
Age Groups ◽  
Gender Effects ◽  
Female Rats ◽  
Male Rats ◽  
Old Rats ◽  
Glucose Stimulated Insulin Secretion ◽  
Total Glucose

Glucose-stimulated insulin secretion was evaluated in whole perfused pancreases and islets of Langerhans (90 to 110 microns diam) isolated from female and male Fischer 344 (F344) rats aged 6, 12, and 26 mo. Total glucose-stimulated (11.1 mmol/l) insulin release of whole perfused pancreases from male rats did not differ among age groups. In contrast, insulin secretion of 26-mo-old female rats was significantly greater than 6- and 12-mo-old female rats. Insulin secretion by islets of Langerhans incubated in glucose concentrations of 11.1, 16.7, and 22.2 mmol/l was greater in male rats compared with age-matched female animals at all three ages, and was greater in 6-vs. 26-mo-old male rats. Insulin secretion of female rats revealed some significant differences among the age groups, although no clear pattern was evident. Sensitivity of the islets to glucose was estimated from the rate of glucose oxidation. At incubation medium glucose concentrations of 11.1 mmol/l or higher, no effect of gender was observed, although the glucose oxidation rate of islets from male 26-mo-old rats was greater than that of islets from gender-matched 6-mo-old rats. These data indicate that in both the whole perfused pancreas and isolated islets of Langerhans, glucose-stimulated insulin secretion is not significantly altered with age or gender in the F344 rat. However, it appears that maintenance of insulin secretory capacity by aging male rats is achieved by enhancement of beta-cell sensitivity to glucose.

Subchronic co-administration to cadmium, diazinon and selenium causes apparent symptoms of osteoporosis in adult male rats

2014 ◽  
Author(s):  
Radoslav Omelka ◽  
Hana Chovancova ◽  
Ivana Bobonova ◽  
Grzegorz Formicki ◽  
Robert Toman ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats
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