scholarly journals Mitochondrial respiratory inhibition by 2,3-butanedione monoxime (BDM): implications for culturing isolated mouse ventricular cardiomyocytes

2016 ◽  
Vol 4 (1) ◽  
pp. e12606 ◽  
Author(s):  
Andrew R. Hall ◽  
Derek J. Hausenloy
Keyword(s):  
Respiratory Inhibition ◽  
Ventricular Cardiomyocytes ◽  
Butanedione Monoxime ◽  
Mitochondrial Respiratory

scholarly journals Correction to: Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

2020 ◽  
Vol 94 (8) ◽  
pp. 2731-2732
Author(s):  
Wanda van der Stel ◽  
Giada Carta ◽  
Julie Eakins ◽  
Salihanur Darici ◽  
Johannes Delp ◽  
...  
Keyword(s):  
Mitochondrial Targeting ◽  
Respiratory Inhibition ◽  
Mitochondrial Respiratory

Mitochondrial Respiratory Inhibition Promoted by Pyraclostrobin in Fungi is Also Observed in Honey Bees

2020 ◽  
Vol 39 (6) ◽  
pp. 1267-1272 ◽  
Author(s):  
Daniel Nicodemo ◽  
Fábio Erminio Mingatto ◽  
David De Jong ◽  
Paulo Francisco Veiga Bizerra ◽  
Marco Aurélio Tavares ◽  
...  
Keyword(s):  
Honey Bees ◽  
Respiratory Inhibition ◽  
Mitochondrial Respiratory

scholarly journals Role of cell contractions in cAMP-induced cardiomyocyte atrial natriuretic peptide release

2000 ◽  
Vol 278 (1) ◽  
pp. H117-H125 ◽  
Author(s):  
D. J. Church ◽  
M. C. Rebsamen ◽  
D. Morabito ◽  
V. van der Bent ◽  
M. B. Vallotton ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Contractile Activity ◽  
Fold Increase ◽  
Prostaglandin E ◽  
Ventricular Cardiomyocytes ◽  
Peptide Release ◽  
Butanedione Monoxime ◽  
Atrial Natriuretic

Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E2 (0.1 μM) or forskolin (0.1 μM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Both responses were maximal within 10–20 min of application and were accompanied by three- to fourfold increases in cAMP formation. By contrast, a higher regimen of forskolin (10 μM) promoted a 20- to 30-fold increase in basal cAMP production, which was accompanied by the abolition of contractile activity and ANP release. Low regimens of forskolin (0.1 μM) doubled the occurrence of cytosolic Ca2+ transients associated with monolayer contraction, whereas higher regimens of forskolin (10 μM) completely suppressed Ca2+transients. Moreover, in quiescent cultures that were pretreated with ryanodine, tetrodotoxin, nifedipine, or butanedione monoxime, prostaglandin E2 (0.1 μM) and forskolin (0.1 μM) failed to elicit significant ANP secretion, suggesting that cAMP-elevating agents promote ANP secretion to a great extent via an increase in cellular contraction frequency in ventricular cardiomyocytes.

Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina

2007 ◽  
Vol 181 (3) ◽  
pp. 435-446 ◽  
Author(s):  
Kun Xiong ◽  
Huaibin Cai ◽  
Xue-Gang Luo ◽  
Robert G. Struble ◽  
Richard W. Clough ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Retina ◽  
Respiratory Inhibition ◽  
And Oxidative Stress ◽  
Mitochondrial Respiratory
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