scholarly journals Reduced vocal variability in a zebra finch model of dopamine depletion: implications for Parkinson disease

2015 ◽  
Vol 3 (11) ◽  
pp. e12599 ◽  
Author(s):  
Julie E. Miller ◽  
George W. Hafzalla ◽  
Zachary D. Burkett ◽  
Cynthia M. Fox ◽  
Stephanie A. White
Keyword(s):  
Parkinson Disease ◽  
Zebra Finch ◽  
Dopamine Depletion ◽  
Vocal Variability

Patterns of striatal dopamine depletion in early Parkinson disease

Neurology ◽  
2020 ◽  
Vol 95 (3) ◽  
pp. e280-e290 ◽  
Author(s):  
Seok Jong Chung ◽  
Hye Sun Lee ◽  
Han Soo Yoo ◽  
Yang Hyun Lee ◽  
Phil Hyu Lee ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Parkinson Disease ◽  
Cox Regression ◽  
Early Stage ◽  
Freezing Of Gait ◽  
Striatal Dopamine ◽  
Dopamine Depletion ◽  
Wearing Off ◽  
Striatal Dopamine Depletion ◽  
Selective Dopamine

ObjectiveTo investigate whether the patterns of striatal dopamine depletion on dopamine transporter (DAT) scans could provide information on the long-term prognosis in Parkinson disease (PD).MethodsWe enrolled 205 drug-naive patients with early-stage PD, who underwent 18F-FP-CIT PET scans at initial assessment and received PD medications for 3 or more years. After quantifying the DAT availability in each striatal subregion, factor analysis was conducted to simplify the identification of striatal dopamine depletion patterns and to yield 4 striatal subregion factors. We assessed the effect of these factors on the development of levodopa-induced dyskinesia (LID), wearing-off, freezing of gait (FOG), and dementia during the follow-up period (6.84 ± 1.80 years).ResultsThe 4 factors indicated which striatal subregions were relatively preserved: factor 1 (caudate), factor 2 (more-affected sensorimotor striatum), factor 3 (less-affected sensorimotor striatum), and factor 4 (anterior putamen). Cox regression analyses using the composite scores of these striatal subregion factors as covariates demonstrated that selective dopamine depletion in the sensorimotor striatum was associated with a higher risk for developing LID. Selective dopamine loss in the putamen, particularly in the anterior putamen, was associated with early development of wearing-off. Selective involvement of the anterior putamen was associated with a higher risk for dementia conversion. However, the patterns of striatal dopamine depletion did not affect the risk of FOG.ConclusionsThese findings suggested that the patterns of striatal dopaminergic denervation, which were estimated by the equation derived from the factor analysis, have a prognostic implication in patients with early-stage PD.

scholarly journals Habitual versus Goal-directed Action Control in Parkinson Disease

2011 ◽  
Vol 23 (5) ◽  
pp. 1218-1229 ◽  
Author(s):  
Sanne de Wit ◽  
Roger A. Barker ◽  
Anthony D. Dickinson ◽  
Roshan Cools
Keyword(s):  
Parkinson Disease ◽  
Disease Severity ◽  
Habit Formation ◽  
Dorsal Striatum ◽  
Dopamine Depletion ◽  
Conflict Task ◽  
Stimulus Response ◽  
Directed Action ◽  
Goal Directed Behavior ◽  
Direct Investigation

This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus–response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus–response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity–dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.

scholarly journals Dopamine Function and the Efficiency of Human Movement

2014 ◽  
Vol 26 (3) ◽  
pp. 645-657 ◽  
Author(s):  
Sergei Gepshtein ◽  
Xiaoyan Li ◽  
Joseph Snider ◽  
Markus Plank ◽  
Dongpyo Lee ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Energy Cost ◽  
Dorsal Striatum ◽  
Human Movement ◽  
Energy Costs ◽  
Dopamine Depletion ◽  
Healthy Elderly ◽  
Efficient Planning ◽  
Implicit Motor ◽  
Successful Behavior

To sustain successful behavior in dynamic environments, active organisms must be able to learn from the consequences of their actions and predict action outcomes. One of the most important discoveries in systems neuroscience over the last 15 years has been about the key role of the neurotransmitter dopamine in mediating such active behavior. Dopamine cell firing was found to encode differences between the expected and obtained outcomes of actions. Although activity of dopamine cells does not specify movements themselves, a recent study in humans has suggested that tonic levels of dopamine in the dorsal striatum may in part enable normal movement by encoding sensitivity to the energy cost of a movement, providing an implicit “motor motivational” signal for movement. We investigated the motivational hypothesis of dopamine by studying motor performance of patients with Parkinson disease who have marked dopamine depletion in the dorsal striatum and compared their performance with that of elderly healthy adults. All participants performed rapid sequential movements to visual targets associated with different risk and different energy costs, countered or assisted by gravity. In conditions of low energy cost, patients performed surprisingly well, similar to prescriptions of an ideal planner and healthy participants. As energy costs increased, however, performance of patients with Parkinson disease dropped markedly below the prescriptions for action by an ideal planner and below performance of healthy elderly participants. The results indicate that the ability for efficient planning depends on the energy cost of action and that the effect of energy cost on action is mediated by dopamine.

Dopamine depletion impairs precursor cell proliferation in Parkinson disease

2004 ◽  
Vol 7 (7) ◽  
pp. 726-735 ◽  
Author(s):  
Günter U Höglinger ◽  
Pamela Rizk ◽  
Marie P Muriel ◽  
Charles Duyckaerts ◽  
Wolfgang H Oertel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Parkinson Disease ◽  
Precursor Cell ◽  
Dopamine Depletion

Presynaptic dopamine depletion predicts levodopa-induced dyskinesia in de novo Parkinson disease

Neurology ◽  
2014 ◽  
Vol 82 (18) ◽  
pp. 1597-1604 ◽  
Author(s):  
J. Y. Hong ◽  
J. S. Oh ◽  
I. Lee ◽  
M. K. Sunwoo ◽  
J. H. Ham ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
De Novo ◽  
Dopamine Depletion

The Pattern of Striatal Dopamine Depletion as a Prognostic Marker in De Novo Parkinson Disease

2018 ◽  
Vol 43 (11) ◽  
pp. 787-792 ◽  
Author(s):  
Seok Jong Chung ◽  
Han Soo Yoo ◽  
Hye Sun Lee ◽  
Jungsu S. Oh ◽  
Jae Seung Kim ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Prognostic Marker ◽  
De Novo ◽  
Striatal Dopamine ◽  
Dopamine Depletion ◽  
Striatal Dopamine Depletion

scholarly journals Is neurogenesis in two songbird species related to their song sequence variability?

2019 ◽  
Vol 286 (1895) ◽  
pp. 20182872 ◽  
Author(s):  
Justina Polomova ◽  
Kristina Lukacova ◽  
Boris Bilcik ◽  
Lubica Kubikova
Keyword(s):  
Zebra Finch ◽  
Subventricular Zone ◽  
Taeniopygia Guttata ◽  
Song Learning ◽  
Sequence Variability ◽  
Bengalese Finch ◽  
Song System ◽  
Proper Name ◽  
Vocal Variability ◽  
Song Sequence

Neurogenesis takes part in the adult songbird brain and new neurons are integrated into the forebrain including defined areas involved in the control of song learning and production. It has been suggested that the new neurons in the song system might enable vocal variability. Here, we examined the basal levels of neurogenesis in two songbird species, zebra finch ( Taeniopygia guttata ) and Bengalese finch ( Lonchura striata var. domestica ), which do not learn new song elements as adults but differ in the level of song sequence variability. We found that Bengalese finches had less linear and stereotyped song sequence and a higher number of newborn cells in the neurogenic subventricular zone (SVZ) as well as the number of newly born neurons incorporated into the vocal nucleus HVC (used as a proper name) in comparison to zebra finches. Importantly, this vocal sequence variability in Bengalese finches correlated with the number of new neurons in the vocal nucleus HVC and more plastic song was associated with higher neuronal incorporation. In summary, our data support the hypothesis that newly generated neurons facilitate behavioural variability.

scholarly journals Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease

2016 ◽  
Vol 28 (5) ◽  
pp. 657-667 ◽  
Author(s):  
Karin Foerde ◽  
Bernd Figner ◽  
Bradley B. Doll ◽  
Isabel C. Woyke ◽  
Erin Kendall Braun ◽  
...  
Keyword(s):  
Decision Making ◽  
Parkinson Disease ◽  
Intertemporal Choice ◽  
Dopamine Depletion ◽  
Choice Problem ◽  
Sensitivity To Reward ◽  
Intertemporal Decisions ◽  
New Evidence ◽  
Dopamine Modulation

Choosing between smaller prompt rewards and larger later rewards is a common choice problem, and studies widely agree that frontostriatal circuits heavily innervated by dopamine are centrally involved. Understanding how dopamine modulates intertemporal choice has important implications for neurobiological models and for understanding the mechanisms underlying maladaptive decision-making. However, the specific role of dopamine in intertemporal decisions is not well understood. Dopamine may play a role in multiple aspects of intertemporal choices—the valuation of choice outcomes and sensitivity to reward delays. To assess the role of dopamine in intertemporal decisions, we tested Parkinson disease patients who suffer from dopamine depletion in the striatum, in either high (on medication, PDON) or low (off medication, PDOFF) dopaminergic states. Compared with both PDOFF and healthy controls, PDON made more farsighted choices and reduced their valuations less as a function of increasing time to reward. Furthermore, reduced discounting in the high dopaminergic state was robust across multiple measures, providing new evidence for dopamine's role in making decisions about the future.

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