scholarly journals Deletion of glycerol channel aquaporin-9 (Aqp9 ) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db ) obese mice

2015 ◽  
Vol 3 (9) ◽  
pp. e12538 ◽  
Author(s):  
Peter Spegel ◽  
Aakash Chawade ◽  
Søren Nielsen ◽  
Per Kjellbom ◽  
Michael Rützler
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Leptin Receptor ◽  
Blood Glucose Control ◽  
Obese Mice ◽  
Aquaporin 9

Early Atherosclerosis Is Retarded by Improved Long-Term Blood Glucose Control in Patients With IDDM

Diabetes ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1253-1258 ◽  
Author(s):  
K. J. Jensen-Urstad ◽  
P. G. Reichard ◽  
J. S. Rosfors ◽  
L. E. L. Lindblad ◽  
M. T. Jensen-Urstad
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Early Atherosclerosis

scholarly journals Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice

2021 ◽  
Author(s):  
Brittany M Duggan ◽  
Akhilesh K Tamrakar ◽  
Nicole G Barra ◽  
Fernando F Anhe ◽  
Gabriella Paniccia ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Blood Glucose ◽  
Gut Microbiota ◽  
Glucose Control ◽  
Subcutaneous Injection ◽  
Blood Glucose Control ◽  
Dependent Manner ◽  
Obese Mice ◽  
Bacterial Extract ◽  
Obesity And Diabetes

Obesity and diabetes increase circulating levels of microbial components derived from the gut microbiota. Individual bacterial factors (i.e., postbiotics) can have opposing effects on metabolic inflammation and blood glucose control. We tested the net effect of gut bacterial extracts on blood glucose using a microbiota-based vaccination strategy in mice. Male and female mice had improved insulin sensitivity and blood glucose control five weeks after a single subcutaneous injection of a specific dose of a bacterial extract obtained from the luminal contents of the proximal gut. Injection of mice with proximal gut extracts from germ-free mice revealed that bacteria were required for a microbiota-based vaccination to improve blood glucose control. Vaccination of Nod1-/-, Nod2-/-, and Ripk2-/- mice showed that each of these innate immune proteins was required for bacterial extract injection to improve blood glucose control. A microbiota-based vaccination promoted a proximal gut immunoglobulin-G (IgG) response directed against bacterial extract antigens, where subcutaneous injection of mice with the luminal contents of the ileum elicited a bacterial extract-specific IgG response that is compartmentalized to the ileum of vaccinated mice. A microbiota-based vaccination was associated with an altered the microbiota composition in the ileum and colon of mice. Lean mice required a single injection of proximal gut bacterial extracts, but high fat diet (HFD)-fed, obese mice required prime-boost bacterial extract injections for improvements in blood glucose control. These data show that, upon subversion of the gut barrier, vaccination with proximal gut bacterial extracts engages innate immunity to promote long-lasting improvements in blood glucose control in a dose-dependent manner.

scholarly journals Clinical evaluation of measuring glycosylated hemoglobin levels for assessing the long-term blood glucose control in diabetics.

1980 ◽  
Vol 27 (4) ◽  
pp. 411-415 ◽  
Author(s):  
MITSUO INADA ◽  
MARIKO OISHI ◽  
MITSUSHIGE NISHIKAWA ◽  
SHUNICHIRO KURATA ◽  
HIROO IMURA
Keyword(s):  
Blood Glucose ◽  
Clinical Evaluation ◽  
Glucose Control ◽  
Glycosylated Hemoglobin ◽  
Blood Glucose Control

Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

2009 ◽  
Vol 390 (1) ◽  
Author(s):  
Nigel Irwin ◽  
Paula L. McClean ◽  
Steven Patterson ◽  
Kerry Hunter ◽  
Peter R. Flatt
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Insulin Response ◽  
Gastric Inhibitory Polypeptide ◽  
Oral Glucose ◽  
Acute Administration ◽  
Passive Immunisation ◽  
Active Immunisation

AbstractRecent research suggests that long-term ablation of gastric inhibitory polypeptide (GIP) receptor signalling can reverse or prevent many of the metabolic abnormalities associated with dietary and genetically induced obesity-diabetes. The present study was designed to assess the sub-chronic effects of passive or active immunisation against GIP inob/obmice. Initial acute administration of GIP antibody together with oral glucose inob/obmice significantly increased the glycaemic excursion compared to controls (p<0.05). This was associated with a significant reduction (p<0.05) in the overall glucose-mediated insulin response. However, sub-chronic passive GIP immunisation was not associated with any changes in body weight, food intake or metabolic control. In contrast, active immunisation against GIP for 56 days in youngob/obmice resulted in significantly (p<0.05) reduced circulating plasma glucose concentrations on day 56 compared to controls. There was a tendency for decreased circulating insulin in GIP immunised mice. The glycaemic response to intraperitoneal glucose was correspondingly improved (p<0.05) in mice immunised against GIP. Glucose-stimulated insulin levels were not significantly different from controls. Furthermore, insulin sensitivity was similar in mice immunised against GIP and respective controls. Overall, the results reveal that active, as opposed to passive, immunisation against GIP improves blood glucose controlob/obmice.

Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus

1977 ◽  
Vol 44 (5) ◽  
pp. 859-864 ◽  
Author(s):  
KENNETH H. GABBAY ◽  
KAREN HASTY ◽  
JAN L. BRESLOW ◽  
R. CURTIS ELLISON ◽  
H. FRANKLIN BUNN ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control
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