scholarly journals Diet-induced obesity impairs muscle satellite cell activation and muscle repair through alterations in hepatocyte growth factor signaling

2015 ◽  
Vol 3 (8) ◽  
pp. e12506 ◽  
Author(s):  
Donna M. D'Souza ◽  
Karin E. Trajcevski ◽  
Dhuha Al-Sajee ◽  
David C. Wang ◽  
Melissa Thomas ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Satellite Cell ◽  
Cell Activation ◽  
Growth Factor Signaling ◽  
Muscle Repair ◽  
Muscle Satellite Cell ◽  
Diet Induced Obesity ◽  
Satellite Cell Activation ◽  
Hepatocyte Growth

Hepatocyte growth factor affects satellite cell activation and differentiation in regenerating skeletal muscle

2000 ◽  
Vol 278 (1) ◽  
pp. C174-C181 ◽  
Author(s):  
Kristy J. Miller ◽  
Deepa Thaloor ◽  
Sarah Matteson ◽  
Grace K. Pavlath
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Satellite Cell ◽  
Cell Activation ◽  
Inhibitory Effect ◽  
Satellite Cell Activation ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF) is the only known growth factor that activates quiescent satellite cells in skeletal muscle. We hypothesized that local delivery of HGF may enhance regeneration after trauma by increasing the number of myoblasts available for restoring normal tissue architecture. Injection of HGF into muscle at the time of injury increases myoblast number but does not enhance tissue repair as determined using quantitative histological analyses. Rather, depending on the dose and the timing of HGF administration relative to the injury, regeneration can be inhibited. The greatest inhibitory effect is observed when HGF is administered on the day of injury and continued for 3 days, corresponding to the time when satellite cell activation, proliferation, and early differentiation normally occur. To establish a mechanism for this inhibition, we show that HGF can act directly on primary muscle cells to block differentiation. These results demonstrate that 1) exogenous HGF synergizes with factors in damaged muscle to increase myoblast number, 2) regeneration is not regulated solely by myoblast number, and 3) HGF inhibits muscle differentiation both in vitro and in vivo.

Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation

2014 ◽  
Vol 326 (1) ◽  
pp. 112-124 ◽  
Author(s):  
Yosuke Nagata ◽  
Kazuya Ohashi ◽  
Eiji Wada ◽  
Yuki Yuasa ◽  
Masataka Shiozuka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Satellite Cell ◽  
Cell Activation ◽  
Muscle Satellite Cell ◽  
Sphingosine 1 Phosphate ◽  
Satellite Cell Activation ◽  
Epidermal Growth
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