scholarly journals Gene expression in salivary glands: effects of diet and mouse chromosome 17 locus regulating macronutrient intake

2015 ◽  
Vol 3 (2) ◽  
pp. e12311 ◽  
Author(s):  
Jacob Simon ◽  
Lisa M. DiCarlo ◽  
Claudia Kruger ◽  
William D. Johnson ◽  
Claudia Kappen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Salivary Glands ◽  
Mouse Chromosome ◽  
Chromosome 17 ◽  
Macronutrient Intake

scholarly journals Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family

2006 ◽  
Vol 28 (1) ◽  
pp. 129-140 ◽  
Author(s):  
John J. Mullins ◽  
Linda J. Mullins ◽  
Donald R. Dunbar ◽  
William J. Brammar ◽  
Kenneth W. Gross ◽  
...  
Keyword(s):  
Amino Acid ◽  
Oral Cavity ◽  
Salivary Glands ◽  
Mouse Chromosome ◽  
Mrna Translation ◽  
Salivary Protein ◽  
Protein Family ◽  
Chromosome 17 ◽  
Complex Region ◽  
T Complex

Salivary fluid, the collective product of numerous major and minor salivary glands, contains a range of secretory proteins that play key defensive, digestive, and gustatory roles in the oral cavity. To understand the distinct protein “signature” contributed by individual salivary glands to salivary secretions, we studied a family of proteins shown by in vitro mRNA translation to be abundantly expressed in mouse sublingual glands. Molecular cloning, Southern blotting, and restriction fragment length polymorphism analyses showed these to represent one known and two novel members of the common salivary protein (CSP-1)/Demilune cell and parotid protein (Dcpp) salivary protein family, the genes for which are closely linked in the T-complex region of mouse chromosome 17. Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. The corresponding human gene displays a similar structure to the mouse Dcpp genes and is located on human chromosome 16 in a region known to be syntenic with the T-complex region of mouse chromosome 17. The predicted mouse and human proteins both display classical NH2-terminal signal sequences, putative jacalin-related lectin domains, and potential N-linked glycosylation sites, suggesting secretion via sublingual saliva into the oral cavity where they may display antimicrobial activity or provide a defensive coating to enamel. Identification of a human CSP-1/Dcpp ortholog therefore provides a key tool for investigation of salivary protein function in human oral health and disease.

The Gene Encoding Protein Kinase SEK1 Maps to Mouse Chromosome 11 and Human Chromosome 17

Genomics ◽  
1996 ◽  
Vol 34 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Robert A. White ◽  
Rowland T. Hughes ◽  
Linda R. Adkison ◽  
Gail Bruns ◽  
Leonard I. Zon
Keyword(s):  
Protein Kinase ◽  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 17 ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Human Chromosome 17 ◽  
Mouse Chromosome 11 ◽  
Encoding Protein

Cloning of a Testis-Specific Gene Located Between Qa-2 and Upg-1 on Mouse Chromosome 17

H-2 Antigens ◽  
1987 ◽  
pp. 321-325
Author(s):  
Masanori Kasahara ◽  
Felipe Figueroa ◽  
Jan Klein
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 17 ◽  
Specific Gene

Molecular Studies of Mouse Chromosome 17 and the T Complex

1984 ◽  
pp. 141-156 ◽  
Author(s):  
Lee M. Silver ◽  
James I. Garrels ◽  
Hans Lehrach
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 17 ◽  
T Complex ◽  
Molecular Studies

scholarly journals Screening of genetic loci predisposing to herpes simplex virus infection on mouse chromosome 17

2016 ◽  
Vol 3 (12) ◽  
pp. 274
Author(s):  
Xiu-Ying Chen ◽  
Wei-Ju Tang ◽  
Xu-Zheng Zuo ◽  
Gong Wang ◽  
Hao-Xiang Wang ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Infection ◽  
Mouse Chromosome ◽  
Herpes Simplex Virus Infection ◽  
Chromosome 17 ◽  
Genetic Loci ◽  
Simplex Virus

Increased expression of interleukin-21-inducible genes in minor salivary glands are associated with primary Sjögren’s syndrome disease characteristics

Rheumatology ◽  
2020 ◽  
Author(s):  
Xiaomin Chen ◽  
Shan Jiang ◽  
Zihao Zhou ◽  
Xin Xu ◽  
Senhong Ying ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
B Cells ◽  
Salivary Glands ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Minor Salivary Glands ◽  
Disease Characteristics ◽  
Inducible Genes ◽  
Sjögren‘S Syndrome

Abstract Objective To determine the upregulation of IL-21-inducible genes in minor salivary glands (MSGs) in 28 primary SS (pSS) patients and 12 non-pSS subjects and correlate it with disease characteristics. Methods RNA sequencing was utilized to compare IL-21-inducible genes expression in the MSGs between pSS and non-pSS subjects. The subgroups were characterized according to the IL-21 score calculated by seven IL-21-inducible genes. Furthermore, the disease characteristics and transcripts implicated in hypoxia and interferon signalling were assessed in two pSS subgroups. Results We observed that the expression of the IL-21-inducible genes (IL-21, IL-21R, JAK3, STAT1, HLA-B, CCR7 and CXCL10), the so-called IL-21 signature genes, was significantly increased in pSS patients. The upregulation of JAK3 expression may be induced by hypomethylation of the JAK3 promoter in pSS patients and putatively associated with POU2F2. The patients with increased IL-21 signature gene expression showed an increased EULAR Sjögren’s Syndrome Disease Activity Index score and increased enrichment of B cells, memory B cells, CD4+ T cells and CD8+ T cells. Furthermore, the IL-21 scores in the anti-SSA+, SSB+, ANA+ and high IgG samples were higher than those in the respective antibody-negative samples and normal IgG. In addition, we found both hypoxia and IFN-relevant genes showed strong correlation with IL-21 signature gene expression, indicating their interaction in pSS. Conclusion IL-21 signature gene was associated with typical disease characteristics in pSS, which provides insight into the contribution of the IL-21 signalling pathway to the pathogenesis of the disease and might provide a novel treatment strategy for this subtype of pSS.

Mouse Chromosome 17

1992 ◽  
Vol 3 (S1) ◽  
pp. S241-S260 ◽  
Author(s):  
Lee M. Silver ◽  
Karen Artzt ◽  
Denise Barlow ◽  
Kirsten Fischer-Lindahl ◽  
Mary F. Lyon ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 17

Genetic mapping of Ptprm on mouse Chromosome 17

1995 ◽  
Vol 6 (10) ◽  
pp. 757-758
Author(s):  
Y. Mukouyama ◽  
T. Watanabe ◽  
T. Kume ◽  
M. Oishi
Keyword(s):  
Genetic Mapping ◽  
Mouse Chromosome ◽  
Chromosome 17

Mapping of acidic epididymal glycoprotein (Aeg) genes to mouse Chromosome 17

1995 ◽  
Vol 6 (1) ◽  
pp. 52-54 ◽  
Author(s):  
M. Kasahara ◽  
M. Hayashi ◽  
M. C. Yoshida ◽  
J. H. Nadeau ◽  
S. Fujimoto ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 17
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