scholarly journals Effects of diaphragmatic contraction on lower limb venous return and central hemodynamic parameters contrasting healthy subjects versus heart failure patients at rest and during exercise

2014 ◽  
Vol 2 (12) ◽  
pp. e12216 ◽  
Author(s):  
Fernanda Machado Balzan ◽  
Régis Chiarelli da Silva ◽  
Danton Pereira da Silva ◽  
Paulo Roberto Stefani Sanches ◽  
Angela Maria Vicente Tavares ◽  
...  
Keyword(s):  
Heart Failure ◽  
Lower Limb ◽  
Healthy Subjects ◽  
Venous Return ◽  
Hemodynamic Parameters ◽  
Heart Failure Patients ◽  
Central Hemodynamic

scholarly journals Heart transplantation waiting list of V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs. Trends from 2010 to 2017

2019 ◽  
Vol 20 (4) ◽  
pp. 8-13 ◽  
Author(s):  
S. V. Gautier ◽  
V. N. Poptsov ◽  
N. N. Koloskova ◽  
V. M. Zakharevich ◽  
A. О. Shevchenko ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Failure ◽  
Heart Transplantation ◽  
Nyha Class ◽  
Waiting List ◽  
Artificial Organs ◽  
Hemodynamic Parameters ◽  
Resonance Imaging ◽  
National Medical ◽  
Central Hemodynamic

The aim:to analyze the waiting list for heart transplantation from 2010 to 2017 and to characterize recipients with chronic heart failure III–IV NYHA Class.Methods.The study comprised 997 patients (139 [14%] females and 858 [86%] males) included in the waiting list for heart transplantation the period from January 2010 to December 2017. The average age of patients on the waiting list was 49.0 ± 12.0 (from 10 to 78 years). Before making a decision on inclusion in the waiting list, all patients underwent clinical and instrumental examination, including general clinical studies, echocardiography, measurement of central hemodynamic parameters using a Swan–Gans catheter, computer and/or magnetic resonance imaging of the chest, abdominal and brain.Results.Heart transplantation was performed on 728 patients (99 females – 13.6% and 629 males – 86.4%) including 18 children aged 12 to 17 years (14.18 ± 2.07 years). Mortality in the waiting list in 2010 was 16.1%, compared with 3.2% in 2017.

Augmented sympathetic neural response to simulated obstructive apnoea in human heart failure

2003 ◽  
Vol 104 (3) ◽  
pp. 231-238 ◽  
Author(s):  
T. Douglas BRADLEY ◽  
Ruzena TKACOVA ◽  
Michael J. HALL ◽  
Shin-ichi ANDO ◽  
John S. FLORAS
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Sympathetic Activity ◽  
Healthy Subjects ◽  
Human Subjects ◽  
Muscle Sympathetic Nerve Activity ◽  
Sleep Apnoea ◽  
Human Heart Failure ◽  
Healthy Human ◽  
Heart Failure Patients

Sleep apnoea in heart failure increases mortality risk, possibly as a result of greater activation of the sympathetic nervous system. In healthy subjects, simulated central apnoeas (holding breath) and obstructive apnoeas (Mueller manoeuvres) increase muscle sympathetic activity equally, primarily through chemoreceptor stimulation. In heart failure, however, Mueller manoeuvres cause greater reductions in blood pressure than breath holds. We hypothesized that in heart failure, the summation of arterial baroreceptor unloading and chemoreceptor stimulation would increase sympathetic activity more during obstructive than central apnoeas. Healthy human subjects and heart failure patients (seven of each) performed 15-s breath holds and 15-s Mueller manoeuvres. Breath holds evoked a progressive increase in muscle sympathetic nerve activity in both groups, but had no effect on blood pressure. In healthy subjects, breath holds and Mueller manoeuvres caused equal peaks in sympathetic activity. In contrast, in heart failure patients, Mueller manoeuvres caused a progressive decrease in blood pressure (P<0.05) and greater increases in sympathetic activity than breath holds (P<0.01). In heart failure, simulated obstructive apnoea elicits greater increases in sympathetic activity than simulated central apnoea, due to its additional hypotensive effect. These present findings offer novel insight into the potential role of sleep apnoea in augmenting sympathetic activity and accelerating disease progression in heart failure.

scholarly journals Effect of aerobic and resistance exercise on central hemodynamic responses in severe chronic heart failure

2002 ◽  
Vol 93 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Craig Cheetham ◽  
Daniel Green ◽  
Julie Collis ◽  
Lawrence Dembo ◽  
Gerard O'Driscoll
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Resistance Exercise ◽  
Upper Limb ◽  
Lower Limb ◽  
Exercise Heart Rate ◽  
Heart Catheterization ◽  
Lower Limb Exercise ◽  
Central Hemodynamic ◽  
Limb Exercise

Exercise is now considered an important component of management in chronic heart failure (CHF), but little is known about central hemodynamic changes that occur during different exercise modalities in these patients. Seventeen patients (ejection fraction 25 ± 2%) undertook brachial artery and right heart catheterization and oxygen consumption assessment at rest, during submaximal and peak cycling (Cyc), and during submaximal upper and lower limb resistance exercise. Cardiac output (CO) increased relative to baseline during peak Cyc ( P < 0.05) but did not change during submaximal Cyc or upper or lower limb exercise. Heart rate (HR) was lowest during upper limb exercise and progressively increased during lower limb exercise, submaximal Cyc, and peak Cyc, with significant differences between each of these ( P< 0.01). Conversely, stroke volume (SV) decreased during submaximal Cyc and lower limb exercise and was lower during peak and submaximal Cyc and lower limb exercise than during upper limb exercise ( P < 0.05). CHF patients are dependent on increases in HR to increase CO during exercise when SV may decline. Resistance exercise, performed at appropriate intensity, induces a similar hemodynamic burden to aerobic exercise in patients with CHF.

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