scholarly journals Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins

2014 ◽  
Vol 2 (5) ◽  
pp. e12016 ◽  
Author(s):  
Hye Jeong Lee ◽  
Min Hyung Kwon ◽  
Soojung Lee ◽  
Randy A. Hall ◽  
C. Chris Yun ◽  
...  
Keyword(s):  
Sodium Bicarbonate ◽  
Scaffold Proteins ◽  
Sodium Bicarbonate Cotransporter

scholarly journals The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH

2018 ◽  
Vol 596 (19) ◽  
pp. 4709-4728 ◽  
Author(s):  
Henriette L. Christensen ◽  
Dagne Barbuskaite ◽  
Aleksandra Rojek ◽  
Hans Malte ◽  
Inga B. Christensen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Sodium Bicarbonate ◽  
Choroid Plexus ◽  
Sodium Bicarbonate Cotransporter

scholarly journals The Functional Complex Composed of the Sodium/Bicarbonate Cotransporter and the Soluble Adenylate Cyclase (sAC) Modulates Basal Cardiac Contractility

2015 ◽  
Vol 108 (2) ◽  
pp. 266a ◽  
Author(s):  
María S. Espejo ◽  
María C. Ciancio ◽  
Alejandro Orlowski ◽  
Verónica C. De Giusti ◽  
Ernesto A. Aiello
Keyword(s):  
Adenylate Cyclase ◽  
Sodium Bicarbonate ◽  
Cardiac Contractility ◽  
Sodium Bicarbonate Cotransporter ◽  
Functional Complex

scholarly journals The Electrogenic Sodium Bicarbonate Cotransporter NBCe1 Is a High-Affinity Bicarbonate Carrier in Cortical Astrocytes

2014 ◽  
Vol 34 (4) ◽  
pp. 1148-1157 ◽  
Author(s):  
S. M. Theparambil ◽  
I. Ruminot ◽  
H.-P. Schneider ◽  
G. E. Shull ◽  
J. W. Deitmer
Keyword(s):  
Sodium Bicarbonate ◽  
High Affinity ◽  
Sodium Bicarbonate Cotransporter ◽  
Cortical Astrocytes

Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye

2001 ◽  
Vol 281 (5) ◽  
pp. F920-F935 ◽  
Author(s):  
Dean Bok ◽  
Matthew J. Schibler ◽  
Alexander Pushkin ◽  
Pejvak Sassani ◽  
Natalia Abuladze ◽  
...  
Keyword(s):  
Protein Expression ◽  
Sodium Bicarbonate ◽  
Molecular Mechanisms ◽  
Coding Region ◽  
Sodium Bicarbonate Cotransporter ◽  
Band Keratopathy ◽  
Proximal Renal Tubular Acidosis ◽  
Renal Tubular ◽  
Protein Variants ◽  
Renal Phenotype

The human NBC1 gene encodes two electrogenic sodium-bicarbonate cotransport proteins, pNBC1 and kNBC1, which are candidate proteins for mediating electrogenic sodium-bicarbonate cotransport in ocular cells. Mutations in the coding region of the human NBC1 gene in exons common to both pNBC1 and kNBC1 result in a syndrome with a severe ocular and renal phenotype (blindness, band keratopathy, glaucoma, cataracts, and proximal renal tubular acidosis). In the present study, we determined the pattern of electrogenic sodium-bicarbonate cotransporter protein expression in rat eye. For this purpose, pNBC1- and kNBC1-specific antibodies were generated and used to detect these NBC1 protein variants by immunoblotting and immunocytochemistry. pNBC1 is expressed in cornea, conjunctiva, lens, ciliary body, and retina, whereas the expression of kNBC1 is restricted to the conjunctiva. These results provide the first evidence for extrarenal kNBC1 protein expression. The data in this study will serve as a basis for understanding the molecular mechanisms responsible for abnormalities in ocular electrogenic sodium-bicarbonate cotransport in patients with mutations in the NBC1 gene.

scholarly journals Salt Sensitivity of Blood Pressure Is Associated With Polymorphisms in the Sodium-Bicarbonate Cotransporter

Hypertension ◽  
2012 ◽  
Vol 60 (5) ◽  
pp. 1359-1366 ◽  
Author(s):  
Robert M. Carey ◽  
Cynthia D. Schoeffel ◽  
John J. Gildea ◽  
John E. Jones ◽  
Helen E. McGrath ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sodium Bicarbonate ◽  
Salt Sensitivity ◽  
Sodium Bicarbonate Cotransporter
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