scholarly journals Association of AXIN1 With Parkinson’s Disease in a Taiwanese Population

2021 ◽  
Author(s):  
Hwa-Shin Fang ◽  
Chih-Ying Chao ◽  
Chun-Chieh Wang ◽  
Wen-Lang Fan ◽  
Po-Jung Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Taiwanese Population

Mutational analysis of FBXO7 gene in Parkinson's disease in a Taiwanese population

2013 ◽  
Vol 34 (6) ◽  
pp. 1713.e1-1713.e4 ◽  
Author(s):  
Chin-Hsien Lin ◽  
Meng-Ling Chen ◽  
Tzu-Ting Lai ◽  
Chun-Hwei Tai ◽  
Ruey-Meei Wu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mutational Analysis ◽  
Taiwanese Population

COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population

2015 ◽  
Vol 36 (1) ◽  
pp. 546.e17-546.e18 ◽  
Author(s):  
Chin-Hsien Lin ◽  
Hang-I Lin ◽  
Meng-Ling Chen ◽  
Ruey-Meei Wu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Taiwanese Population

Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population

2014 ◽  
Vol 35 (5) ◽  
pp. 1212.e11-1212.e13 ◽  
Author(s):  
Chin-Hsien Lin ◽  
Kai-Hsiang Chen ◽  
Meng-Ling Chen ◽  
Han-I. Lin ◽  
Ruey-Meei Wu
Keyword(s):  
Parkinson’S Disease ◽  
Vitamin D ◽  
Parkinson's Disease ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
Taiwanese Population

Genetic analysis of PODXL gene in patients with familial and young-onset Parkinson's disease in a Taiwanese population

2019 ◽  
Vol 84 ◽  
pp. 235.e9-235.e10 ◽  
Author(s):  
Szu-Ju Chen ◽  
Ruey-Meei Wu ◽  
Chang-Han Ho ◽  
Jay Cheng ◽  
Han-Yi Lin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Analysis ◽  
Taiwanese Population ◽  
Young Onset

scholarly journals Polymorphisms of Interleukin-6 and Interleukin-8 Are Not Associated with Parkinson’s Disease in Taiwan

2021 ◽  
Vol 11 (6) ◽  
pp. 768
Author(s):  
Tsai-Wei Liu ◽  
Yih-Ru Wu ◽  
Yi-Chun Chen ◽  
Hon Chung Fung ◽  
Chiung-Mei Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Variants ◽  
Late Onset ◽  
Age At Onset ◽  
Nucleotide Polymorphisms ◽  
Taiwanese Population ◽  
Negative Results ◽  
Allelic Distribution ◽  
And Gender

Background: Studies have suggested that cytokines are crucial mediators in the pathogenesis of Parkinson’s disease (PD). The multifunctional cytokine interleukin (IL)-6 and its single nucleotide polymorphisms (SNPs) were found to have an impact on the development of PD. However, different studies in associations of IL-6 genetic variants with PD showed inconsistent results and it has never been explored in a Taiwanese population. Both IL-1α and IL-8 contribute to the same inflammation pathway. IL-1α genetic polymorphism has an effect on late-onset PD in Taiwan, whereas the associations of IL-8 genetic variants with PD in Taiwan remain to be investigated. Methods: This study examined the frequencies of polymorphisms within the critical promoter areas of the proinflammatory cytokine genes: IL-6 G-174C (rs1800795) and IL-8 A-251T (rs4073) in Taiwanese PD patients compared with age-and gender-matched healthy subjects. Comparisons were also made in genotype and allele frequencies of IL-6 G-174C (rs1800795) and IL-8 A-251T (rs4073) among different populations in previous studies. Results: In total, 1120 subjects, including 509 PD patients (female/male: 259/250) and 511 control subjects (female/male: 252/259), were recruited. We found no statistically significant differences in IL-6 G-174C (rs1800795) or IL-8 A-251T (rs4073) genotypic and allelic distribution between PD and controls, even after being stratified by age at onset and gender. Conclusions: The results did not demonstrate any association of IL-6 G-174C (rs1800795) or IL-8 A-251T (rs4073) with PD in a Taiwanese population. Despite the negative results, this is the first study in associations of IL-6 G-174C (rs1800795) and IL-8 A-251T (rs4073) with PD in Taiwan. The relevance of genetic variants of IL-6 G-174C (rs1800795) or IL-8 A-251T (rs4073) on PD susceptibility warrants further investigation.

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

2012 ◽  
Vol 18 (6) ◽  
pp. 753-758 ◽  
Author(s):  
Mark L. Wahlqvist ◽  
Meei-Shyuan Lee ◽  
Chih-Cheng Hsu ◽  
Shao-Yuan Chuang ◽  
Jiunn-Tay Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Taiwanese Population ◽  
Population Cohort

Mutational analysis of SYNJ1 gene (PARK20) in Parkinson's disease in a Taiwanese population

2015 ◽  
Vol 36 (10) ◽  
pp. 2905.e7-2905.e8 ◽  
Author(s):  
Kai-Hsiang Chen ◽  
Ruey-Meei Wu ◽  
Hang-I Lin ◽  
Chun-Hwei Tai ◽  
Chin-Hsien Lin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mutational Analysis ◽  
Taiwanese Population
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