scholarly journals Transient Hypersomnolence Provoked by Metoclopramide in a Patient with Degenerative Parkinsonism

2019 ◽  
Vol 12 (1) ◽  
pp. 60-62
Author(s):  
Sang-Won Yoo ◽  
Ko Eun Choi ◽  
Joong-Seok Kim
Keyword(s):  
Degenerative Parkinsonism

Degenerative Parkinsonism

2013 ◽  
pp. 548-548
Author(s):  
C. Renn Upchurch Sweeney ◽  
J. Rick Turner ◽  
J. Rick Turner ◽  
Chad Barrett ◽  
Ana Victoria Soto ◽  
...  
Keyword(s):  
Degenerative Parkinsonism

scholarly journals Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal 123I-FP-CIT indices

2019 ◽  
Vol 266 (7) ◽  
pp. 1771-1781 ◽  
Author(s):  
Nicolas Nicastro ◽  
Jennifer Wegrzyk ◽  
Maria Giulia Preti ◽  
Vanessa Fleury ◽  
Dimitri Van de Ville ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Support Vector ◽  
Machine Analysis ◽  
Degenerative Parkinsonism

Clinical and Genetic Aspects of Progressive Supranuclear Palsy

1998 ◽  
Vol 11 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Irene Litvan ◽  
Michael Hutton
Keyword(s):  
Linkage Disequilibrium ◽  
Diagnostic Accuracy ◽  
Progressive Supranuclear Palsy ◽  
Frontotemporal Dementia ◽  
Clinical Features ◽  
Neuronal Degeneration ◽  
Chromosome 17 ◽  
Clinical Criteria ◽  
Degenerative Parkinsonism ◽  
Research Studies

Progressive supranuclear palsy (PSP) is, after Parkinson's disease, the most common form of degenerative parkinsonism. Several clinical features are used in the recognition of this disorder as well as in the differentiation from related disorders. Clinical criteria that could increase diagnostic accuracy in research studies are also emphasized. Due to a better understanding of the genetic aspects of PSP, recent studies have suggested that it is a recessive disorder in linkage disequilibrium with the tau (τ) gene, rather than a sporadic disorder. In addition, the recent identification of mutations in the τ gene associated with a similar neurodegenerative condition (frontotemporal dementia and parkinsonism linked to chromosome 17) has further strengthened the argument that τ dysfunction is somehow involved in the pathogenesis of PSP. Nongenetic factors that could trigger or perpetuate the cascade of events leading to neuronal degeneration in PSP are also reviewed.

Early Onset Degenerative Parkinsonism – Consider SPG7 Mutation

2021 ◽  
Vol 69 (4) ◽  
pp. 1051
Author(s):  
Shakya Bhattacharjee ◽  
Muhammad Noushad ◽  
Martin Sadler
Keyword(s):  
Early Onset ◽  
Degenerative Parkinsonism

scholarly journals Single-site 123I-FP-CIT reference values from individuals with non-degenerative parkinsonism—comparison with values from healthy volunteers

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Rachid Fahmi ◽  
Günther Platsch ◽  
Alexandre Bani Sadr ◽  
Sylvain Gouttard ◽  
Stephane Thobois ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Reference Values ◽  
Single Site ◽  
Degenerative Parkinsonism

WED 106 Unilateral abnormal dat scan: early indicator of parkinson’s disease

2018 ◽  
Vol 89 (10) ◽  
pp. A11.3-A11
Author(s):  
Heng Nicholas ◽  
Chin Mei Ying ◽  
Monaghan Clare ◽  
Davidson John ◽  
Gilbertson Tom ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Predictive Factor ◽  
Demographic Data ◽  
Tertiary Institution ◽  
Parkinsonian Syndromes ◽  
Dat Scan ◽  
Diagnostic Changes ◽  
Degenerative Parkinsonism

IntroductionDopamine transporter (DaT) scans are used in the investigation of clinically uncertain Parkinsonian syndromes (CUPS). Presently, bilateral abnormal DaT scans are diagnostic of Parkinson’s disease and degenerative Parkinsonism, while normal scans suggest non-degenerative causes. However, the clinical significance of unilateral abnormal scans remains ambiguous. Therefore, we aimed to determine their relevance in CUPS, and hypothesised that they may presage Parkinson’s disease and degenerative Parkinsonism.MethodsA retrospective analysis was performed for patients with CUPS within a tertiary institution who had undergone DaT scans. Demographic data, clinical features, imaging and diagnoses were collected. In patients with unilateral scans, follow-up assessments, further imaging and diagnostic changes were also recorded.ResultsA total of 200 DaT scans were performed from 1 January 2008 to 1 January 2017. There were 100 (50.0%) with normal scans, 77 (38.5%) with bilateral scans, and 23 (11.5%) with unilateral scans. Of the latter group (n=23), 8 (34.8%) underwent follow-up DaT imaging in a mean period of 31.9±12.6 months from baseline, with 4 (17.4%) now reported as bilateral, although 2 (8.7%) remained unilateral and 2 (8.7%) were reported as normal.ConclusionUnilateral DaT scans can serve as a predictive factor for development of Parkinson’s disease and degenerative Parkinsonism.

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