scholarly journals Isolated Neurological Manifestation in Silent Celiac Disease

2017 ◽  
Vol 10 (2) ◽  
pp. 105-107
Author(s):  
Salma Tarabzouni ◽  
Thamer AlKhairallah
Keyword(s):  
Celiac Disease ◽  
Neurological Manifestation

scholarly journals Rare Neurological Manifestation of Celiac Disease

2015 ◽  
Vol 9 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Uzma Rani ◽  
Aamer Imdad ◽  
Mirza Beg
Keyword(s):  
Celiac Disease ◽  
Psychiatric Symptoms ◽  
Tissue Transglutaminase ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Pseudotumor Cerebri ◽  
Neurological Manifestation ◽  
Upper Gastrointestinal Endoscopy ◽  
Blurred Vision ◽  
And Behavior

Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and psychiatric symptoms, which makes its diagnosis difficult and challenging. Known neurological manifestations of CD include epilepsy with or without occipital calcification, attention deficit hyperactivity disorder and ataxia, headache, neuropathies and behavior disorders. We present the case of a 14-year-old female with headaches and blurred vision for 1 year; she was noted to have papilledema on ophthalmic examination with increased cerebrospinal fluid opening pressure on lumber puncture and was diagnosed as a case of pseudotumor cerebri (PTC). Meanwhile her workup for chronic constipation revealed elevated tissue transglutaminase IgA and antiendomysial IgA antibodies. Upper gastrointestinal endoscopy with duodenal biopsy confirmed the diagnosis of CD. The patient was started on a gluten-free diet, leading to resolution of not only gastrointestinal symptoms but also to almost complete resolution of symptoms of PTC. This report describes the correlation of CD and PTC as its neurological manifestation.

scholarly journals Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 380 ◽  
Author(s):  
Elizabeth Mearns ◽  
Aliki Taylor ◽  
Kelly Thomas Craig ◽  
Stefanie Puglielli ◽  
Daniel Leffler ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gastrointestinal Disorder ◽  
Neurological Manifestation ◽  
Cochrane Library ◽  
Unknown Etiology ◽  
Neurological Manifestations ◽  
Gluten Ataxia ◽  
Immune Mediated ◽  
Increased Risk ◽  
The Cochrane Library

Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. MEDLINE, Embase, the Cochrane Library, and conference proceedings were systematically searched from January 2007 through September 2018. Included studies evaluated patients with CD with at least one neurological manifestation of interest and reported prevalence, and/or incidence, and/or clinical outcomes. Sixteen studies were included describing the risk of gluten neuropathy and/or gluten ataxia in patients with CD. Gluten neuropathy was a neurological manifestation in CD (up to 39%) in 13 studies. Nine studies reported a lower risk and/or prevalence of gluten ataxia with a range of 0%–6%. Adherence to a gluten-free diet appeared to improve symptoms of both neuropathy and ataxia. The prevalence of gluten neuropathy and gluten ataxia in patients with CD varied in reported studies, but the increased risk supports the need for physicians to consider CD in patients with ataxia and neurological manifestations of unknown etiology.

Multiphasic disseminated encephalomyelitis followed by optic neuritis in a child with gluten sensitivity

2015 ◽  
Vol 21 (9) ◽  
pp. 1209-1211 ◽  
Author(s):  
BH Ching ◽  
AR Mohamed ◽  
TB Khoo ◽  
HIHM Ismail
Keyword(s):  
Celiac Disease ◽  
Optic Neuritis ◽  
Clinical History ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Accurate Diagnosis ◽  
Neurological Manifestation ◽  
Gluten Sensitivity ◽  
Therapeutic Implications

Multiphasic disseminated encephalomyelitis (MDEM) followed by optic neuritis (ON) has been described as a new entity in recent years. Gluten encephalopathy has also been recognized as a neurological manifestation of celiac disease. Accurate diagnosis of both is important due to the therapeutic implications. We report a girl presenting with recurrent encephalopathic polyfocal demyelinating episodes followed by optic neuritis, and a clinical history suggestive of gluten sensitivity. She had persistently high ESR, neutrophilia, and tested positive for anti-MOG (myelin oligodendrocyte glycoprotein) antibody. She responded well to methylprednisolone in each relapse, and achieved remission for a year after azathioprine was added.

Tissue transglutaminase, the celiac disease autoantigen, preferentially generates antigenic neoepitopes in γ and γ but not in α gliadins

2001 ◽  
Vol 120 (5) ◽  
pp. A684-A684
Author(s):  
D TRAPP ◽  
W DIETERICH ◽  
H WIESER ◽  
M LEIDENBERGER ◽  
D SEILMEIER ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase

IgA-antitissue transglutaminase: Sensitivity and specificity for diagnosing Celiac Disease

2001 ◽  
Vol 120 (5) ◽  
pp. A395-A395
Author(s):  
J WEST ◽  
A LLOYD ◽  
P HILL ◽  
G HOLMES
Keyword(s):  
Celiac Disease ◽  
Sensitivity And Specificity

High prevalence of celiac disease in Migraine

2001 ◽  
Vol 120 (5) ◽  
pp. A393-A393
Author(s):  
M GABRIELLI ◽  
C PADALINO ◽  
E LEO ◽  
S DANESE ◽  
G FIORE ◽  
...  
Keyword(s):  
Celiac Disease ◽  
High Prevalence

Gender-related differences in pathogenesis and response to treatment of bone disorders of celiac disease (CD) patients

2001 ◽  
Vol 120 (5) ◽  
pp. A392-A392
Author(s):  
J FERRETI ◽  
R MAZURE ◽  
P TANOUE ◽  
A MARINO ◽  
G COINTRY ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Response To Treatment ◽  
Bone Disorders

Increased rectal permeability in celiac disease

2001 ◽  
Vol 120 (5) ◽  
pp. A131-A132
Author(s):  
E SMECUOL ◽  
E SUGAI ◽  
R DEZI ◽  
S NIVELONI ◽  
I DOLDAN ◽  
...  
Keyword(s):  
Celiac Disease

The apoptotic pathway is disturbed in the active and inactive celiac disease

2001 ◽  
Vol 120 (5) ◽  
pp. A131-A131
Author(s):  
J VANDERWOUDE ◽  
T TIEBOSCH ◽  
M HOMAN ◽  
A BEUVING ◽  
J KLEIBEUKER ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Apoptotic Pathway

759 IMMUNE CHECKPOINT INHIBITOR-ASSOCIATED CELIAC DISEASE

2020 ◽  
Vol 158 (6) ◽  
pp. S-156
Author(s):  
Yousef R. Badran ◽  
Angela Shih ◽  
Donna Leet ◽  
Alexandra Coromilas ◽  
Jonathan Chen ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor
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