scholarly journals Cellular effectors and transduction pathways as therapeutic targets in cholinergic-dependent neuropsychiatric disorders

2018 ◽  
Vol 4 ◽  
Keyword(s):  
Therapeutic Targets ◽  
Neuropsychiatric Disorders

Novel Therapeutic Targets in Neuropsychiatric Disorders: The Neuroepigenome

2014 ◽  
Vol 20 (11) ◽  
pp. 1831-1839 ◽  
Author(s):  
Lucio Tremolizzo ◽  
Virginia Rodriguez-Menendez ◽  
Elisa Conti ◽  
Chiara Zoia ◽  
Guido Cavaletti ◽  
...  
Keyword(s):  
Therapeutic Targets ◽  
Neuropsychiatric Disorders ◽  
Novel Therapeutic

scholarly journals The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders

2021 ◽  
Vol 22 (9) ◽  
pp. 4307
Author(s):  
Kinga Sałaciak ◽  
Aleksandra Koszałka ◽  
Elżbieta Żmudzka ◽  
Karolina Pytka
Keyword(s):  
Drug Design ◽  
Therapeutic Targets ◽  
Neuropsychiatric Disorders ◽  
Cellular Functions ◽  
Calcium Calmodulin Dependent ◽  
Regulatory Processes ◽  
Neuropsychiatric Diseases ◽  
Future Drug ◽  
Structure And Functions

CaMKII and CaMKIV are calcium/calmodulin-dependent kinases playing a rudimentary role in many regulatory processes in the organism. These kinases attract increasing interest due to their involvement primarily in memory and plasticity and various cellular functions. Although CaMKII and CaMKIV are mostly recognized as the important cogs in a memory machine, little is known about their effect on mood and role in neuropsychiatric diseases etiology. Here, we aimed to review the structure and functions of CaMKII and CaMKIV, as well as how these kinases modulate the animals’ behavior to promote antidepressant-like, anxiolytic-like, and procognitive effects. The review will help in the understanding of the roles of the above kinases in the selected neurodegenerative and neuropsychiatric disorders, and this knowledge can be used in future drug design.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

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