Mitochondrial DNA alteration and pathological progression in colorectal cancer

2016 ◽  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna

scholarly journals Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk

2008 ◽  
Vol 99 (12) ◽  
pp. 2088-2093 ◽  
Author(s):  
E Webb ◽  
P Broderick ◽  
I Chandler ◽  
S Lubbe ◽  
S Penegar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Cancer Risk ◽  
Comprehensive Analysis ◽  
Colorectal Cancer Risk ◽  
Dna Variants ◽  
Mitochondrial Dna Variants

scholarly journals Pre-diagnostic leukocyte mitochondrial DNA copy number and colorectal cancer risk

2019 ◽  
Vol 40 (12) ◽  
pp. 1462-1468 ◽  
Author(s):  
Keming Yang ◽  
Xin Li ◽  
Michele R Forman ◽  
Patrick O Monahan ◽  
Bret H Graham ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Quantitative Polymerase Chain Reaction ◽  
Conditional Logistic Regression ◽  
Experimental Studies ◽  
Inverse Association ◽  
Mitochondrial Dna Copy Number ◽  
Increased Risk

Abstract Mitochondrial DNA (mtDNA) is susceptible to oxidative stress and mutation. Few epidemiological studies have assessed the relationship between mtDNA copy number (mtDNAcn) and risk of colorectal cancer (CRC), with inconsistent findings. In this study, we examined the association between pre-diagnostic leukocyte mtDNAcn and CRC risk in a case–control study of 324 female cases and 658 matched controls nested within the Nurses’ Health Study (NHS). Relative mtDNAcn in peripheral blood leukocytes was measured by quantitative polymerase chain reaction-based assay. Conditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association of interest. Results showed lower log-mtDNAcn was significantly associated with increased risk of CRC, in a dose-dependent relationship (P for trend < 0.0001). Compared to the fourth quartile, multivariable-adjusted OR [95% confidence interval (CI)] was 1.10 (0.69, 1.76) for the third quartile, 1.40 (0.89, 2.19) for the second quartile and 2.19 (1.43, 3.35) for the first quartile. In analysis by anatomic subsite of CRC, we found a significant inverse association for proximal colon cancer [lowest versus highest quartile, multivariable-adjusted OR (95% CI) = 3.31 (1.70, 6.45), P for trend = 0.0003]. Additionally, stratified analysis according to the follow-up time since blood collection showed that the inverse association between mtDNAcn and CRC remained significant among individuals with ≥ 5 years’ follow-up, and marginally significant among those with ≥ 10 years’ follow-up since mtDNAcn testing, suggesting that mtDNAcn may serve as a long-term predictor for risk of CRC. In conclusion, pre-diagnostic leukocyte mtDNAcn was inversely associated with CRC risk. Further basic experimental studies are needed to explore the underlying biological mechanisms linking mtDNAcn to CRC carcinogenesis.

Abstract 4281: Mitochondrial DNA copy number, urinary isoprostanes and colorectal cancer risk

2016 ◽  
Author(s):  
Bharat Thyagarajan ◽  
Renwei Wang ◽  
Woon-Puay Koh ◽  
Helene Barcelo ◽  
Jennifer Adams-Haduch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Cancer Risk ◽  
Copy Number ◽  
Colorectal Cancer Risk ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer

2015 ◽  
Vol 62 (3) ◽  
pp. 625-627 ◽  
Author(s):  
Katarzyna Linkowska ◽  
Arkadiusz Jawień ◽  
Andrzej Marszałek ◽  
Katarzyna Skonieczna ◽  
Tomasz Grzybowski
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Cag Repeat ◽  
Repeat Polymorphism ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Mitochondrial Dna Polymerase

scholarly journals Association between pre-diagnostic leukocyte mitochondrial DNA copy number and survival among colorectal cancer patients

2020 ◽  
Vol 68 ◽  
pp. 101778
Author(s):  
Keming Yang ◽  
Michele R. Forman ◽  
Brett H. Graham ◽  
Patrick O. Monahan ◽  
Edward L. Giovannucci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Cancer Patients ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number ◽  
Colorectal Cancer Patients

Mitochondrial DNA mutations in colorectal cancer a prognostic and a predictive factor of response to adjuvant chemotherapy

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9614-9614
Author(s):  
A. Lievre ◽  
C. Chapusot ◽  
A.-M. Bouvier ◽  
F. Zinzindohoue ◽  
F. Piard ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Adjuvant Chemotherapy ◽  
Predictive Factor ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

Effect of surgical stress on nuclear and mitochondrial DNA from healthy sections of colon and rectum of patients with colorectal cancer

2011 ◽  
Vol 36 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Lucia Potenza ◽  
Cinzia Calcabrini ◽  
Roberta De Bellis ◽  
Umberto Mancini ◽  
Emanuela Polidori ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Surgical Stress ◽  
Colon And Rectum
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