scholarly journals MicroRNA miR-124a, a negative regulator of insulin secretion, is hyperexpressed in human pancreatic islets of type 2 diabetic patients

RNA & DISEASE ◽  
2015 ◽  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Negative Regulator ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Human Pancreatic Islets ◽  
Type 2 Diabetic

scholarly journals DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

2012 ◽  
Vol 31 (6) ◽  
pp. 1405-1426 ◽  
Author(s):  
Michael Volkmar ◽  
Sarah Dedeurwaerder ◽  
Daniel A Cunha ◽  
Matladi N Ndlovu ◽  
Matthieu Defrance ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Pancreatic Islets ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Dna Methylation Profiling ◽  
Type 2 Diabetic ◽  
Methylation Profiling

scholarly journals Pattern of distribution of IGF-1 and EGF in pancreatic islets of type 2 diabetic patients

Islets ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 102-105 ◽  
Author(s):  
Suhail Al-Salam ◽  
Raheed Hameed ◽  
Hasan Parvez ◽  
Ernest Adeghate
Keyword(s):  
Pancreatic Islets ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Beneficial Effects of Insulin Versus Sulphonylurea on Insulin Secretion and Metabolic Control in Recently Diagnosed Type 2 Diabetic Patients

Diabetes Care ◽  
2003 ◽  
Vol 26 (8) ◽  
pp. 2231-2237 ◽  
Author(s):  
M. Alvarsson ◽  
G. Sundkvist ◽  
I. Lager ◽  
M. Henricsson ◽  
K. Berntorp ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Metabolic Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Beneficial Effects ◽  
Type 2 Diabetic

scholarly journals Decrement of postprandial insulin secretion determines the progressive nature of type-2 diabetes

2006 ◽  
Vol 155 (4) ◽  
pp. 615-622 ◽  
Author(s):  
Wan Sub Shim ◽  
Soo Kyung Kim ◽  
Hae Jin Kim ◽  
Eun Seok Kang ◽  
Chul Woo Ahn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Diabetic Patients ◽  
Β Cell ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Duration Of Diabetes ◽  
Type 2 Diabetic ◽  
Postprandial Insulin

Objective: Type-2 diabetes is a progressive disease. However, little is known about whether decreased fasting or postprandial pancreatic β-cell responsiveness is more prominent with increased duration of diabetes. The aim of this study was to evaluate the relationship between insulin secretion both during fasting and 2 h postprandial, and the duration of diabetes in type-2 diabetic patients. Design: Cross-sectional clinical investigation. Methods: We conducted a meal tolerance test in 1466 type-2 diabetic patients and calculated fasting (M0) and postprandial (M1) β-cell responsiveness. Results: The fasting C-peptide, postprandial C-peptide, M0, and M1 values were lower, but HbA1c values were higher, in patients with diabetes duration > 10 years than those in other groups. There was no difference in the HbA1c levels according to the tertiles of their fasting C-peptide level. However, in a group of patients with highest postprandial C-peptide tertile, the HbA1c values were significantly lower than those in other groups. After adjustment of age, sex, and body mass index (BMI), the duration of diabetes was found to be negatively correlated with fasting C-peptide (γ = −0.102), postprandial C-peptide (γ = −0.356), M0 (γ = −0.263), and M1 (γ = −0.315; P < 0.01 respectively). After adjustment of age, sex, and BMI, HbA1c was found to be negatively correlated with postprandial C-peptide (γ = −0.264), M0 (γ = −0.379), and M1 (γ = −0.522), however, positively correlated with fasting C-peptide (γ = 0.105; P < 0.01 respectively). In stepwise multiple regression analysis, M0, M1, and homeostasis model assessment for insulin resistance (HOMA-IR) emerged as predictors of HbAlc after adjustment for age, sex, and BMI (R2 = 0.272, 0.080, and 0.056 respectively). Conclusions: With increasing duration of diabetes, the decrease of postprandial insulin secretion is becoming more prominent, and postprandial β-cell responsiveness may be a more important determinant for glycemic control than fasting β-cell responsiveness.

Insulin Clamp–Derived Measurements of Insulin Sensitivity and Insulin Secretion in Lean and Obese Asian Type 2 Diabetic Patients

2010 ◽  
Vol 8 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Swangjit Suraamornkul ◽  
Rachaneewon Kwancharoen ◽  
Mudjalin Ovartlarnporn ◽  
Petch Rawdaree ◽  
Mandeep Bajaj
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Insulin Clamp ◽  
Type 2 Diabetic
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