Allosteric modulation and potential therapeutic applications of heteromeric nicotinic acetylcholine receptors

Faculty Opinions recommendation of Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092041.553238 ◽

2007 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Self Administration ◽

Nicotinic Acetylcholine

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Allosteric Modulation of Nicotinic Acetylcholine Receptors: The Concept and Therapeutic Trends

Current Pharmaceutical Design ◽

10.2174/1381612822666160201115341 ◽

2016 ◽

Vol 22 (14) ◽

pp. 1986-1997 ◽

Cited By ~ 7

Author(s):

Victor V. Uteshev

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

European Journal of Pharmacology ◽

10.1016/s0014-2999(00)00093-5 ◽

2000 ◽

Vol 393 (1-3) ◽

pp. 165-170 ◽

Cited By ~ 156

Author(s):

Alfred Maelicke ◽

Edson X Albuquerque

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Nicotinic Acetylcholine Receptors ◽

Treatment Strategy ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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Allosteric modulation of nicotinic acetylcholine receptors

Biochemical Pharmacology ◽

10.1016/j.bcp.2015.07.028 ◽

2015 ◽

Vol 97 (4) ◽

pp. 408-417 ◽

Cited By ~ 53

Author(s):

Anna Chatzidaki ◽

Neil S. Millar

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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Allosteric modulation of alpha4beta2 nicotinic acetylcholine receptors by HEPES

European Journal of Pharmacology ◽

10.1016/j.ejphar.2012.06.001 ◽

2014 ◽

Vol 732 ◽

pp. 159-168 ◽

Cited By ~ 9

Author(s):

Maegan M. Weltzin ◽

Yanzhou Huang ◽

Marvin K. Schulte

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors

Journal of Biological Chemistry ◽

10.1074/jbc.m116.751206 ◽

2016 ◽

Vol 292 (2) ◽

pp. 551-562 ◽

Cited By ~ 20

Author(s):

Constanza Alcaino ◽

Maria Musgaard ◽

Teresa Minguez ◽

Simone Mazzaferro ◽

Manuel Faundez ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Transmembrane Domain ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors

Biochemical Pharmacology ◽

10.1016/j.bcp.2009.06.020 ◽

2009 ◽

Vol 78 (7) ◽

pp. 836-843 ◽

Cited By ~ 33

Author(s):

David B. Sattelle ◽

Steven D. Buckingham ◽

Miki Akamatsu ◽

Kazuhiko Matsuda ◽

Ilse Pienaar ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Computational Modelling ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2014.11.027 ◽

2015 ◽

Vol 91 ◽

pp. 157-168 ◽

Cited By ~ 4

Author(s):

Caitlin A. Short ◽

Angela T. Cao ◽

Molly A. Wingfield ◽

Matthew E. Doers ◽

Emily M. Jobe ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

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Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2017.04.008 ◽

2017 ◽

Vol 127 ◽

pp. 224-242 ◽

Cited By ~ 6

Author(s):

Monique J. Windley ◽

Irina Vetter ◽

Richard J. Lewis ◽

Graham M. Nicholson

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Spider Venom ◽

Lethal Effects ◽

Nicotinic Acetylcholine ◽

Venom Peptide

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Intrinsically Low Open Probability of α7 Nicotinic Acetylcholine Receptors Can Be Overcome by Positive Allosteric Modulation and Serum Factors Leading to the Generation of Excitotoxic Currents at Physiological Temperatures

Molecular Pharmacology ◽

10.1124/mol.112.080317 ◽

2012 ◽

Vol 82 (4) ◽

pp. 746-759 ◽

Cited By ~ 47

Author(s):

Dustin K. Williams ◽

Can Peng ◽

Matthew R. Kimbrell ◽

Roger L. Papke

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Open Probability ◽

Nicotinic Acetylcholine ◽

Serum Factors ◽

Α7 Nicotinic Acetylcholine Receptors

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