New prognostic biomarkers in patients with ischemic stroke

2016 ◽  
Keyword(s):  
Ischemic Stroke ◽  
Prognostic Biomarkers

scholarly journals Role of Blood-Based Biomarkers in Ischemic Stroke Prognosis

Stroke ◽  
2021 ◽  
Vol 52 (2) ◽  
pp. 543-551 ◽  
Author(s):  
Felipe A. Montellano ◽  
Kathrin Ungethüm ◽  
Laura Ramiro ◽  
Aliona Nacu ◽  
Simon Hellwig ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Prognostic Factors ◽  
Sample Size ◽  
Systematic Reviews ◽  
Natriuretic Peptides ◽  
Prognostic Biomarkers ◽  
Fatty Acid Binding ◽  
Previous Systematic Review ◽  
Poor Outcome

Background and Purpose: Outcome prognostication in ischemic stroke patients remains challenging due to limited predictive properties of existing models. Blood-based biomarkers might provide additional information to established prognostic factors. We intended to identify the most promising prognostic biomarkers in ischemic stroke, their incremental prognostic value, and whether their predictive value differs among etiologies. Methods: We searched MEDLINE (Ovid) and Institute for Scientific Information Web of Knowledge for articles reporting the predictive performance of blood-based biomarkers measured up to 7 days after ischemic stroke and reporting functional outcome or death at least 7 days after stroke. This work updates a previous systematic review (up to January 2007), follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and was registered (International Prospective Register of Systematic Reviews PROSPERO 2018; https://www.crd.york.ac.uk/PROSPERO /; Unique identifier: CRD42018094671). Results: Two hundred ninety-one articles published between January 2007 and August 2018 comprising 257 different biomarkers met inclusion criteria. Median sample size was 232 (interquartile range, 110–455); 260 (89%) articles reported regression analyses with 78% adjusting for stroke severity, 82% for age, 67% for both, and 9% for none of them; 37% investigated discrimination, 5% calibration, and 11% reclassification. Including publications from a previous systematic review (1960–January 2007), natriuretic peptides, copeptin, procalcitonin, mannose-binding lectin, adipocyte fatty acid–binding protein, and cortisol were the biomarkers most consistently associated with poor outcome in higher-quality studies showing an incremental value over established prognostic factors. Other biomarkers were less consistently associated with poor outcome or were reported in lower quality studies. High heterogeneity among studies precluded the performance of a meta-analysis. Conclusions: The number of reports on prognostic blood-based biomarkers in ischemic stroke increased 3.5-fold in the period January 2007 to August 2018. Although sample size increased, methodological flaws are still common. Natriuretic peptides and markers of inflammation, atherogenesis, and stress response are the most promising prognostic biomarkers among identified studies.

scholarly journals MicroRNAs as Diagnostic and Prognostic Biomarkers in Ischemic Stroke—A Comprehensive Review and Bioinformatic Analysis

Cells ◽  
2018 ◽  
Vol 7 (12) ◽  
pp. 249 ◽  
Author(s):  
Ceren Eyileten ◽  
Zofia Wicik ◽  
Salvatore De Rosa ◽  
Dagmara Mirowska-Guzel ◽  
Aleksandra Soplinska ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Blood Coagulation ◽  
Platelet Activation ◽  
Target Genes ◽  
Neurological Diseases ◽  
Mirna Gene ◽  
Bioinformatic Analysis ◽  
Prognostic Biomarkers ◽  
Detection Methods ◽  
Gene Target

Stroke is the second-most common cause of death worldwide. The pathophysiology of ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and platelet activation. MicroRNAs (miRNAs) play important roles in physiological and pathological processes of neurodegenerative diseases and progression of certain neurological diseases, such as IS. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of IS. The capacity of miRNAs to simultaneously regulate several target genes underlies their unique value as diagnostic and prognostic markers in IS. In this review, we focus on the role of miRNAs as diagnostic and prognostic biomarkers in IS. We discuss the most common and reliable detection methods available and promising tests currently under development. We also present original results from bioinformatic analyses of published results, identifying the ten most significant genes (HMGB1, YWHAZ, PIK3R1, STAT3, MAPK1, CBX5, CAPZB, THBS1, TNFRSF10B, RCOR1) associated with inflammation, blood coagulation, and platelet activation and targeted by miRNAs in IS. Additionally, we created miRNA-gene target interaction networks based on Gene Ontology (GO) information derived from publicly available databases. Among our most interesting findings, miR-19a-3p is the most widely modulated miRNA across all selected ontologies and might be proposed as novel biomarker in IS to be tested in future studies.

scholarly journals Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

2014 ◽  
Vol 44 ◽  
pp. 16-23 ◽  
Author(s):  
Sevilay SEZER ◽  
Fatma UÇAR ◽  
Ersin Kasım ULUSOY ◽  
Serpil ERDOĞAN ◽  
Şule BİLEN ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Prognostic Biomarkers ◽  
Pentraxin 3 ◽  
Fetuin A ◽  
Amyloid A
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