Hypoxic pulmonary hypertension and the role of extra-cellular hemoglobin in perivascular macrophage accumulation

Macrophage ◽  
2015 ◽  
Keyword(s):  
Pulmonary Hypertension ◽  
Hypoxic Pulmonary Hypertension ◽  
Perivascular Macrophage ◽  
Macrophage Accumulation

The role of endothelin-1 in strain-related susceptibility to develop hypoxic pulmonary hypertension in rats

2001 ◽  
Vol 128 (2) ◽  
pp. 219-227 ◽  
Author(s):  
M.R. Karamsetty ◽  
L. Pietras ◽  
J.R. Klinger ◽  
J.J. Lanzillo ◽  
J.C. Leiter ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Hypoxic Pulmonary Hypertension ◽  
Endothelin 1

scholarly journals Role of Histamine in Hypoxic Pulmonary Hypertension in the Rat

1968 ◽  
Vol 22 (3) ◽  
pp. 385-392 ◽  
Author(s):  
ANTON HAUGE ◽  
KENNETH L. MELMON
Keyword(s):  
Pulmonary Hypertension ◽  
Hypoxic Pulmonary Hypertension

scholarly journals Protective Role of Myelocytic Nitric Oxide Synthases in Hypoxic Pulmonary Hypertension in Mice

2018 ◽  
Vol WCP2018 (0) ◽  
pp. OR20-1
Author(s):  
Masato Tsutsui ◽  
Takaaki Ogoshi ◽  
Takashi Kido ◽  
Sohsuke Yamada ◽  
Ke-Yong Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Protective Role ◽  
Nitric Oxide Synthases ◽  
Hypoxic Pulmonary Hypertension

scholarly journals The Role of Collagen Synthesis in Ventricular and Vascular Adaptation to Hypoxic Pulmonary Hypertension

2012 ◽  
Author(s):  
David Schreier ◽  
Timothy Hacker ◽  
Guoqing Song ◽  
Naomi Chesler
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Collagen Synthesis ◽  
Pulmonary Arteries ◽  
Hypoxic Pulmonary Hypertension ◽  
Arterial Stiffening ◽  
Vascular Adaptation ◽  
Small Vessels ◽  
Effects Of Ph

Pulmonary hypertension (PH) is a debilitating disease that affects millions of Americans. Most research to date has focused on the deleterious effects of PH within the small vessels of the lungs that determine resistance. A relatively recent focus of PH is on the large pulmonary arteries (PAs) that provide compliance. Loss of compliance in these arteries, or arterial stiffening, is an excellent predictor of mortality in PH [1], which is most often caused by right ventricular (RV) hypertrophy and failure [2].

scholarly journals N7-methylguanosine modification of lncRNAs in a rat model of hypoxic pulmonary hypertension: a comprehensive analysis

BMC Genomics ◽  
2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Huan Wang ◽  
Ren Biao Chen ◽  
Si Ni Zhang ◽  
Rui Feng Zhang
Keyword(s):  
Pulmonary Hypertension ◽  
Clinical Significance ◽  
Rat Model ◽  
Critical Role ◽  
Comprehensive Analysis ◽  
Differentially Expressed ◽  
Hypoxic Pulmonary Hypertension ◽  
Non Coding Rnas ◽  
First Time

Abstract Background Long non-coding RNAs (lncRNAs) play a critical role in the pathogenesis of hypoxic pulmonary hypertension (HPH). The role of N7-methylguanosine (m7G) modification in lncRNAs has received increased attentions in recent years. However, the m7G-methylation of lncRNA in HPH has yet to be determined. We have therefore performed a transcriptome-wide analysis of m7G lncRNAs in HPH. Results Differentially-expressed m7Gs were detected in HPH, and m7G lncRNAs were significantly upregulated compared with non-m7G lncRNAs in HPH. Importantly, this was the first time that the upregulated m7G lncXR_591973 and m7G lncXR_592398 were identified in HPH. Conclusion This study provides the first m7G transcriptome-wide analysis of HPH. Importantly, two HPH-associated m7G lncRNAs were identified, although their clinical significance requires further validation.

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