scholarly journals Role of caveolin-2 in subcutaneous tumor growth and angiogenesis associated with syngeneic mouse Lewis lung carcinoma and B16 melanoma models

2015 ◽  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
B16 Melanoma ◽  
Lewis Lung ◽  
Subcutaneous Tumor ◽  
Syngeneic Mouse

scholarly journals new bIologIcal model of moderate InhIbItIon of tumor and metastases growth wIth prolonged leukopenIa In mIce

2016 ◽  
Vol 1 (5) ◽  
pp. 121-125
Author(s):  
Зуева ◽  
Elena Zueva ◽  
Разина ◽  
Tatyana Razina ◽  
Ермакова ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Tumor Therapy ◽  
Biological Model ◽  
Tumor Growth Inhibition ◽  
Lewis Lung ◽  
Inhibition Of Tumor Growth ◽  
Toxic Manifestation ◽  
Cyclophosphamide Dose

A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57Bl/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclo-phosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34% on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7times (p<0,01). Metastatic area reduced. Metastasis frequency made 100%. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia.

Can 18F-alfatide micro-PET predict the radiotherapy response in Lewis lung carcinoma tumor-bearing C57BL/6 mice?

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23011-e23011
Author(s):  
Yuchun Wei ◽  
Ning Liu ◽  
Yong Huang ◽  
Xudong Hu ◽  
Shuanghu Yuan
Keyword(s):  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Integrin Αvβ3 ◽  
Significant Negative Correlation ◽  
Lewis Lung ◽  
Positron Emission ◽  
Pet Scanning ◽  
Before And After ◽  
Predictive Role

e23011 Background: Integrin αvβ3 plays a major role in angiogenesis, tumor growth and progression. A new tracer, 18F-AL-NOTA-PRGD2, denoted as 18F-Alfatide, has been developed for positron emission tomography (PET) imaging of integrin αvβ3. This study aimed to explore the predictive role of integrin αvβ3 imaging with 18F-Alfatide PET in non-small cell lung cancer (NSCLC) for radiation and also to assess changes in tumor uptake during the course of radiotherapy. Methods: A total of 40 mice with lewis lung carcinoma (LLC) xenografts were divided into 4 groups (Ⅰ, Ⅱ, Ⅲ and Ⅳ) randomly. The Ⅰ underwent 18F-Alfatide Micro-PET scanning before and after radiotherapy, and so did the Ⅱ except for radiotherapy. The xenografts of Ⅲ were removed at the time before radiotherapy, while the Ⅳ’s were removed after radiotherapy. Tumor and muscle uptakes before and after radiotherapy of Ⅰ(SUVrad-1, SUVrad-2, SUVM-1, SUVM-2) and Ⅱ(SUVblank-1, SUVblank-2, SUVm-1, SUVm-2) depict 18F-Alfatide Micro-PET uptake. The expression of integrin αvβ3 in Ⅲ and Ⅳ xenografts was analyzed by western blotting. Results: The changes of ΔSUV1 ( SUVrad-2/SUVM-2―SUVrad-1/SUVM-1) was significantly lower than ΔSUV2 (SUVblank-2/ SUVm-2―SUVblank-1/ SUVm-1 ) (2.65±1.72 versus 5.16±2.50, P = 0.019. Overall survival (OS) of Ⅰ(56.70±25.34 day) is significantly longer than Ⅱ(35.00±5.27 day), P = 0.002. Significant negative correlation was found between ΔSUV and OS (R = 0.640, P = 0.002). Significant higher αvβ3 was observed in Ⅲ(0.52±0.09) than Ⅳ(0.41±0.07), P = 0.007. Conclusions: Decrease of ΔSUV and integrin αvβ3 during the course of radiotherapy may predict improved response in LLC xenografts and affirm the predictive role of 18F-Alfatide for radiation in NSCLC.

scholarly journals Enhancement of radiosensitivity by inhibition of c-Jun N-terminal kinase activity in a Lewis lung carcinoma-bearing subcutaneous tumor mouse model

2016 ◽  
Vol 36 (6) ◽  
pp. 3397-3404
Author(s):  
Chun-Hao Li ◽  
Sa-Hoe Lim ◽  
Hyang-Hwa Ryu ◽  
Kyung-Sub Moon ◽  
Tae-Young Jung ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Kinase Activity ◽  
Lewis Lung ◽  
Subcutaneous Tumor ◽  
Tumor Mouse Model

scholarly journals ATIQCTPC targeting MMP-9: a key step to slowing primary tumor growth and inhibiting metastasis of lewis lung carcinoma in vivo

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 63881-63889 ◽  
Author(s):  
Yuji Wang ◽  
Xinyi Xu ◽  
Ce Song ◽  
Jianhui Wu ◽  
Xi Hu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Primary Tumor ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Primary Tumor Growth

Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice

Pneumologie ◽  
2006 ◽  
Vol 60 (S 1) ◽  
Author(s):  
S Rajkumar ◽  
R Schermuly ◽  
M Schneider ◽  
S Pullamsetti ◽  
F Grimminger ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Prevent Tumor Growth
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