scholarly journals Assesment of Platelet to lymphocyte ratio and Neutrophil to Lymphocyte Ratio in Ulcerative Colitis: A Retrospective Study

2017 ◽  
Vol 1 ◽  
Author(s):  
Kemal Fidan
Keyword(s):  
Ulcerative Colitis ◽  
Retrospective Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Relation between Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Cerebral Infarct Volume in patients with Ischemic Stroke.

2021 ◽  
Vol 5 (1) ◽  
pp. 769-772
Author(s):  
Avni Uygar Seyhan ◽  
Erdal Yilmaz ◽  
Semih Korkut
Keyword(s):  
Emergency Department ◽  
Ischemic Stroke ◽  
Retrospective Study ◽  
Stroke Volume ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Term Survival ◽  
Stroke Incidence ◽  
Lymphocyte Ratio ◽  
Emergency Doctors

Abstract :  Objectives: The activation of inflammatory processes in ischemic stroke might be important for the pathophysiological processes of ischemic stroke. The correlation between the Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR) and stroke volume is increasingly being recognized as a prognostic biomarker for patient outcome after an ischemic stroke incidence. This retrospective study aimed at determining if there is existed correlation between the NLR, PLR and stroke volume in patients presenting with ischemic stroke at the emergency department. The results will aid emergency doctors to gain an understanding on how to rapidly identify the most high-risk patients based on the NLR and taPLR obtained from routine blood tests permitting rapidly therapeutic interventions and better long-term survival outcomes for patients with ischemic strokes.  Methods: A retrospective study was performed between May 2016-2019. Patients 18 years and older of both genders presented to the emergency department with symptoms of ischemic stroke with time of onset of symptoms within the last 24 hours of whom complete blood count (CBC) tests were conducted and ischemic stroke was confirmed by Diffusion weighted Magnetic Resonance Imaging (DWI-MRI) were enrolled. NLR and PLR were calculated from CBC tests and ischemic stroke volume was measured in mm3 using Manual Segmentation Process. Results: A total of 489 patients were enrolled in this study of which 266 (54.5%) were male and 223 (45.6%) were female. It was observed a statistically significant correlation between the ischemic stroke volume and NLR while no significant correlation was observed between stroke volume and PLR. Conclusion: There is a significant weak positive relationship between NLR and ischemic stroke volume. NLR is significantly correlated with cerebral ischemic stroke volume and thus can be utilized as a guide by emergency doctors in the emergency department to predict the severity and the outcome of patients diagnosed with ischemic stroke.

Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated With Anti-TNF: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

2020 ◽  
Vol 26 (10) ◽  
pp. 1579-1587 ◽  
Author(s):  
Lorenzo Bertani ◽  
Federico Rossari ◽  
Brigida Barberio ◽  
Maria Giulia Demarzo ◽  
Gherardo Tapete ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Remission ◽  
Corticosteroid Treatment ◽  
Fecal Calprotectin ◽  
Mucosal Healing ◽  
Neutrophil To Lymphocyte Ratio ◽  
First Year ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Early Predictors

Abstract Background Anti-tumor necrosis factor drugs (anti-TNFs) are widely used for the treatment of ulcerative colitis (UC). However, many patients experience loss of response during the first year of therapy. An early predictor of clinical remission and mucosal healing is needed. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of subclinical inflammation poorly evaluated in UC patients treated with anti-TNFs. The aim of this multicenter study was to evaluate whether NLR and PLR could be used as prognostic markers of anti-TNF treatment response. Methods Patients with UC who started anti-TNF treatment in monotherapy were evaluated. Patients with concomitant corticosteroid treatment ≥20 mg were excluded. We calculated NLR, PLR, and fecal calprotectin before treatment and after induction. The values of NLR and PLR were correlated with clinical remission and mucosal healing at the end of follow-up (54 weeks) using the Mann-Whitney U test and then multivariate analysis was conducted. Results Eighty-eight patients were included. Patients who reached mucosal healing after 54 weeks of therapy displayed lower levels of both baseline NLR and PLR (P = 0.0001 and P = 0.04, respectively); similar results were obtained at week 8 (P = 0.0001 and P = 0.001, respectively). Patients who presented with active ulcers at baseline endoscopic evaluation had higher baseline NLR and PLR values compared with those without detected ulcers (P = 0.002 and P = 0.0007, respectively). Conclusions BothNLR and PLR showed a promising role as early predictors of therapeutic response to anti-TNF therapy in UC patients. If confirmed in larger studies, classification and regression trees proposed in this article could be useful to guide clinical decisions regarding anti-TNF treatment.

scholarly journals Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio Predict Mucosal Disease Severity in Ulcerative Colitis

2018 ◽  
Vol 37 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Muhammet Yener Akpinar ◽  
Yasemin Ozderin Ozin ◽  
Mustafa Kaplan ◽  
Ihsan Ates ◽  
Ismail Hakki Kalkan ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
High Risk ◽  
Disease Severity ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Mucosal Disease ◽  
Cutoff Values ◽  
Risk Patients ◽  
Active Disease

SummaryBackground:We investigated the sensitivity of neutrophil to lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as a combination of NLR and PLR to predict endoscopic disease severity based on mucosal assessment in ulcerative colitis (UC).Methods:The study group consisted 104 patients with active UC, 104 patients in remission, and 105 healthy individuals. Disease activity was described with Rachmilewitz endoscopic activity index (EAI). Curve analysis was used to determine the optimal cutoff values of NLR and PLR for obtaining remission. The patients with both PLR and NLR values higher than the cutoff values were coded as »high risk,« those with one parameter higher were coded as »moderate risk«, those with both parameters lower than the cutoff values were coded as »low-risk« patients.Results:The mean NLR and PLR values in the endoscopically active disease group were higher than the others, with higher values in the endoscopic remission group compared with the control group (p<0.001). Rachmilewitz EAI in high-risk patients was significantly higher than that in others (p<0.001). In Cox regression analyses, moderate and high risk, high erythrocyte sedimentation rate and high EAI were found as independent predictors of endoscopic active disease.Conclusions:This is the first study that investigated the use of NLR and PLR combination to assess endoscopic disease severity in UC. Either high NLR or PLR levels can predict active endoscopic disease. However, the use of these parameters in combination is more accurate in evaluating mucosal disease and inflammation in UC.

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