scholarly journals Analysis of Demographics and Outcomes of Surgical Resection in the Central Nervous System of Patients With Metastatic Melanoma

2021 ◽  
Vol 12 (6) ◽  
pp. 225-231
Author(s):  
Achuta Kumar Guddati ◽  
Hector Picon
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Melanoma ◽  
Surgical Resection ◽  
The Central Nervous System

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

2017 ◽  
Vol 48 (06) ◽  
pp. 403-412 ◽  
Author(s):  
Dimitrios Anestis ◽  
Christina Ble ◽  
Vassilios Tsitouras ◽  
Christos Tsonidis ◽  
Parmenion Tsitsopoulos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glioblastoma Multiforme ◽  
Natural History ◽  
Surgical Resection ◽  
Treatment Strategies ◽  
Molecular Profile ◽  
Rare Tumor ◽  
Mortality And Morbidity ◽  
The Central Nervous System

AbstractCongenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

scholarly journals Meningioangiomatosis: Clinical, Imaging, and Histopathologic Characteristics

2020 ◽  
Vol 10 ◽  
pp. 36
Author(s):  
Mina S. Makary ◽  
Peter Kobalka ◽  
Pierre Giglio ◽  
H. Wayne Slone
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Surgical Resection ◽  
Benign Lesion ◽  
Total Resection ◽  
Clinical Imaging ◽  
Radiographic Appearance ◽  
Calcified Lesion ◽  
The Central Nervous System

Meningioangiomatosis is a rare benign lesion involving the central nervous system. Radiographic appearance can be highly variable which makes pre-operative diagnosis difficult. In this report, we describe meningioangiomatosis in a previously healthy 17-year-old woman who presented with seizures and continued headache and dizziness. This patient presented with a predominately calcified lesion on imaging and eventually underwent near total resection. Meningioangiomatosis is difficult to preoperatively identify, but is an important consideration as prognosis with surgical resection is typically good.

scholarly journals Metastatic Melanoma With Leptomeningeal Disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Amanda M. Marinova, MS, PA-C ◽  
Jennifer L. Reilly, CRNP, BSN, MSN, RN, AANP ◽  
Victoria Wong, MS, PA-C ◽  
Stephanie Weiss, MD ◽  
Anthony J. Olszanski, MD
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Metastatic Melanoma ◽  
Central Nervous System Involvement ◽  
Leptomeningeal Disease ◽  
Leptomeningeal Involvement ◽  
Improved Outcomes ◽  
The Central Nervous System ◽  
Systemic Therapies

Leptomeningeal disease in patients with melanoma historically portends a grim prognosis, with median survival measured in weeks to months. The advent of effective immunotherapy and targeted agents may modify the outcome of such patients. This case report describes a 43-year-old patient diagnosed with stage IIIa BRAF-positive cutaneous melanoma in 2012 who subsequently developed leptomeningeal involvement as her sole site of melanotic metastasis. She received multiple systemic therapies and radiotherapy and survived 2.5 years after her diagnosis with central nervous system involvement. This case report highlights the importance of a multidisciplinary team and the advent of effective agents, which offers the potential for significantly improved outcomes for patients with metastatic melanoma involving the central nervous system.

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