scholarly journals Effect of Rapamycin on the Radio-Sensitivity of Cultured Tumor Cells Following Boron Neutron Capture Reaction

2020 ◽  
Vol 11 (4) ◽  
pp. 158-164
Author(s):  
Hitoshi Tatebe ◽  
Shin-ichiro Masunaga ◽  
Yasumasa Nishimura
Keyword(s):  
Tumor Cells ◽  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Boron Neutron Capture ◽  
Radio Sensitivity ◽  
Cultured Tumor Cells

scholarly journals Translational Evaluation of a Dodecaborated Albumin Conjugate With Maleimide as a Boron Delivery System for a Neutron Capture Reaction to an F98 Rat Glioma Model

2021 ◽  
Author(s):  
Hideki Kashiwagi ◽  
Shinji Kawabata ◽  
Kohei Yoshimura ◽  
Yusuke Fukuo ◽  
Takuya Kanemitsu ◽  
...  
Keyword(s):  
Delivery System ◽  
Neutron Irradiation ◽  
Neutron Capture ◽  
Control Group ◽  
Clinical Settings ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Boron Neutron Capture

Abstract Boron neutron capture therapy (BNCT) is a biologically targeted, cell-selective particle irradiation therapy that utilizes the nuclear capture reaction of boron and neutron. Recently, accelerator neutron generators have been used in clinical settings, and expectations for developing new boron compounds are growing. In this study, we focused on serum albumin, a well-known drug delivery system, and developed maleimide-functionalized closo-dodecaborate albumin conjugate (MID-AC) as a boron carrying system for BNCT. Our biodistribution experiment involved F98 glioma-bearing rat brain tumor models systemically administered with MID-AC and demonstrated accumulation and long retention of boron. Our BNCT study with MID-AC observed statistically significant prolongation of the survival rate compared to the control groups, with results comparable to BNCT study with boronophenylalanine (BPA) which is the standard use of in clinical settings. Each median survival time was as follows: untreated control group; 24.5 days, neutron-irradiated control group; 24.5 days, neutron irradiation following 2.5 hours after termination of intravenous administration (i.v.) of BPA; 31.5 days, and neutron irradiation following 2.5 or 24 hours after termination of i.v. of MID-AC; 33.5 or 33.0 days, respectively. The biological effectiveness factor of MID-AC for F98 rat glioma was estimated based on these survival times and found to be higher to 12. This tendency was confirmed in BNCT 24 hours after MID-AC administration. MID-AC induces an efficient boron neutron capture reaction because the albumin contained in MID-AC is retained in the tumor and has a considerable potential to become an effective delivery system for BNCT in treating high-grade gliomas.

The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

2020 ◽  
Vol 165 ◽  
pp. 109271
Author(s):  
Shou Wang ◽  
Kazuyo Igawa ◽  
Ryo Ogawara ◽  
Mitsuru Suda ◽  
Tsuyoshi Hamano ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Neutron Capture ◽  
Evaluation System ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Boron Neutron Capture

Procedures of radiotherapy with boron neutron capture reaction at the Petten irradiation facility

1999 ◽  
Vol 35 ◽  
pp. S98-S99
Author(s):  
K. Hideghéty ◽  
W. Sauerwein ◽  
C. Vroegindeweij ◽  
R.L. Moss ◽  
P. Watkins ◽  
...  
Keyword(s):  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Boron Neutron Capture

Demonstration of the bactericidal effects of the boron neutron capture reaction

2018 ◽  
Vol 137 ◽  
pp. 190-193 ◽  
Author(s):  
Charles A. Maitz ◽  
John D. Brockman ◽  
Ming Yang ◽  
Shuping Zhang ◽  
James Stannard ◽  
...  
Keyword(s):  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Boron Neutron Capture ◽  
Bactericidal Effects

Dosimetry of the boron neutron capture reaction for BNCT and BNCEFNT

1999 ◽  
Vol 175 (S2) ◽  
pp. 115-118 ◽  
Author(s):  
Jay Burmeister ◽  
Chandrasekhar Kota ◽  
Richard L. Maughan
Keyword(s):  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Boron Neutron Capture
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