scholarly journals Copy Number Variation of the Salivary Amylase Gene and Glucose Metabolism in Healthy Young Japanese Women

2020 ◽  
Vol 12 (3) ◽  
pp. 184-189 ◽  
Author(s):  
Ryoko Higuchi ◽  
Taizo Iwane ◽  
Ayaka Iida ◽  
Kei Nakajima
Keyword(s):  
Glucose Metabolism ◽  
Copy Number Variation ◽  
Copy Number ◽  
Japanese Women ◽  
Amylase Gene ◽  
Salivary Amylase ◽  
Number Variation ◽  
Young Japanese Women

Dietary starch intake modifies the relation between copy number variation in the salivary amylase gene and BMI

2017 ◽  
Vol 106 (1) ◽  
pp. 256-262 ◽  
Author(s):  
Gull Rukh ◽  
Ulrika Ericson ◽  
Johanna Andersson-Assarsson ◽  
Marju Orho-Melander ◽  
Emily Sonestedt
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Amylase Gene ◽  
Salivary Amylase ◽  
Number Variation ◽  
Dietary Starch

scholarly journals Human amylase gene copy number variation as a determinant of metabolic state

2018 ◽  
Vol 13 (4) ◽  
pp. 193-205 ◽  
Author(s):  
Patrick J.D. Elder ◽  
David B. Ramsden ◽  
David Burnett ◽  
Martin O. Weickert ◽  
Thomas M. Barber
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Amylase Gene ◽  
Metabolic State ◽  
Gene Copy Number Variation ◽  
Number Variation

scholarly journals Diet and the evolution of human amylase gene copy number variation

2007 ◽  
Vol 39 (10) ◽  
pp. 1256-1260 ◽  
Author(s):  
George H Perry ◽  
Nathaniel J Dominy ◽  
Katrina G Claw ◽  
Arthur S Lee ◽  
Heike Fiegler ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Amylase Gene ◽  
Gene Copy Number Variation ◽  
Number Variation

scholarly journals Interaction Effect Between Copy Number Variation in Salivary Amylase Locus (AMY1) and Starch Intake on Glucose Homeostasis in the Malmö Diet and Cancer Cohort

2021 ◽  
Vol 7 ◽  
Author(s):  
Aida Koder Hamid ◽  
Johanna Andersson-Assarsson ◽  
Ulrika Ericson ◽  
Emily Sonestedt
Keyword(s):  
Type 2 Diabetes ◽  
Copy Number Variation ◽  
Glucose Homeostasis ◽  
Copy Number ◽  
Inverse Association ◽  
Salivary Amylase ◽  
Cross Sectional ◽  
Copy Numbers ◽  
Number Variation

Salivary amylase initiates the digestion of starch and it has been hypothesized that salivary amylase may play a role in the development of insulin resistance and type 2 diabetes. The aim was to examine the interaction between copy number variation in the salivary amylase gene AMY1 and starch intake. We studied 3,624 adults without diabetes or elevated blood glucose in the Malmö Diet Cancer cohort. We assessed the associations and interactions between starch intake, AMY1 copies and glucose homeostasis traits (i.e., fasting plasma glucose, insulin and HOMA-IR) and risk of type 2 diabetes over an average of 18 follow-up years. AMY1 copy number was not associated with glucose, insulin or HOMA-IR. We observed a significant interaction between starch intake and AMY1 copies on insulin and HOMA-IR after adjusting for potential confounders (p < 0.05). The inverse association between starch intake and insulin and HOMA-IR was stronger in the group with 10 or more copies (Ptrend < 0.001). In addition, we observed an inverse association between starch intake and type 2 diabetes in the group with 10 or more copies (ptrend = 0.003), but not in the other groups. This cross-sectional observational study suggests that AMY1 copy numbers might interact with starch intake on glucose homeostasis traits. Interventional studies are required to determine whether individuals with high AMY1 copy numbers may benefit from a high starch intake.

Identification of Novel Germline and Tumor-Specific Nucleotide Variants and Copy Number Variation in Clival Chordomas by Exome Sequencing

2015 ◽  
Vol 76 (S 01) ◽  
Author(s):  
Georgios Zenonos ◽  
Peter Howard ◽  
Maureen Lyons-Weiler ◽  
Wang Eric ◽  
William LaFambroise ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Exome Sequencing ◽  
Copy Number ◽  
Number Variation ◽  
Specific Nucleotide

The impact of paralog genes: detection of copy number variation in spinal muscle atrophy patients

BIOCELL ◽  
2018 ◽  
Vol 42 (3) ◽  
pp. 87-91 ◽  
Author(s):  
Sergio LAURITO ◽  
Juan A. CUETO ◽  
Jimena PEREZ ◽  
Mar韆 ROQU�
Keyword(s):  
Copy Number Variation ◽  
Muscle Atrophy ◽  
Copy Number ◽  
Number Variation ◽  
The Impact
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