scholarly journals The Opioid System and Food Intake: Use of Opiate Antagonists in Treatment of Binge Eating Disorder and Abnormal Eating Behavior

2020 ◽  
Vol 12 (2) ◽  
pp. 41-63 ◽  
Author(s):  
Leon P. Valbrun ◽  
Valeriy Zvonarev
Keyword(s):  
Eating Disorder ◽  
Food Intake ◽  
Binge Eating ◽  
Eating Behavior ◽  
Binge Eating Disorder ◽  
Opioid System ◽  
Opiate Antagonists ◽  
Abnormal Eating ◽  
Abnormal Eating Behavior

The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder

2006 ◽  
Vol 406 (1-2) ◽  
pp. 133-137 ◽  
Author(s):  
Palmiero Monteleone ◽  
Roberta Zanardini ◽  
Alfonso Tortorella ◽  
Massimo Gennarelli ◽  
Eloisa Castaldo ◽  
...  
Keyword(s):  
Eating Disorder ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Eating Behavior ◽  
Binge Eating Disorder ◽  
Bdnf Gene ◽  
Val66met Polymorphism

scholarly journals Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder

2020 ◽  
Vol 45 (11) ◽  
pp. 1931-1941 ◽  
Author(s):  
Adele Romano ◽  
Maria Vittoria Micioni Di Bonaventura ◽  
Cristina Anna Gallelli ◽  
Justyna Barbara Koczwara ◽  
Dorien Smeets ◽  
...  
Keyword(s):  
Eating Disorder ◽  
Nucleus Accumbens ◽  
Food Intake ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Female Rats ◽  
Early Gene ◽  
Mrna Levels ◽  
Palatable Food ◽  
Brain Areas

Abstract Binge eating disorder (BED) is the most frequent eating disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus highlighting the need for novel treatment options. The lipid-derived messenger oleoylethanolamide (OEA) acts as a satiety signal inhibiting food intake through the involvement of central noradrenergic and oxytocinergic neurons. We investigated the anti-binge effects of OEA in a rat model of binge-like eating, in which, after cycles of intermittent food restrictions/refeeding and palatable food consumptions, female rats show a binge-like intake of palatable food, following a 15-min exposure to their sight and smell (“frustration stress”). Systemically administered OEA dose-dependently (2.5, 5, and 10 mg kg−1) prevented binge-like eating. This behavioral effect was associated with a decreased activation (measured by mapping the expression of c-fos, an early gene widely used as a marker of cellular activation) of brain areas responding to stress (such as the nucleus accumbens and amygdala) and to a stimulation of areas involved in the control of food intake, such as the VTA and the PVN. These effects were paralleled, also, to the modulation of monoamine transmission in key brain areas involved in both homeostatic and hedonic control of eating. In particular, a decreased dopaminergic response to stress was observed by measuring dopamine extracellular concentrations in microdialysates from the nucleus accumbens shell, whereas an increased serotonergic and noradrenergic tone was detected in tissue homogenates of selected brain areas. Finally, a decrease in corticotropin-releasing factor (CRF) mRNA levels was induced by OEA in the central amygdala, while an increase in oxytocin mRNA levels was induced in the PVN. The restoration of a normal oxytocin receptor density in the striatum paralleled the oxytocinergic stimulation produced by OEA. In conclusion, we provide evidence suggesting that OEA might represent a novel potential pharmacological target for the treatment of binge-like eating behavior.

scholarly journals Expectations, mood, and eating behavior in binge eating disorder. Beware of the bright side

Appetite ◽  
2009 ◽  
Vol 53 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Alexandra E. Dingemans ◽  
Carolien Martijn ◽  
Eric F. van Furth ◽  
Anita T.M. Jansen
Keyword(s):  
Eating Disorder ◽  
Binge Eating ◽  
Eating Behavior ◽  
Binge Eating Disorder ◽  
Bright Side

scholarly journals Self-efficacy beliefs and eating behavior in adolescent girls at-risk for excess weight gain and binge eating disorder

2013 ◽  
Vol 46 (7) ◽  
pp. 663-668 ◽  
Author(s):  
Deborah R. Glasofer ◽  
David A.F. Haaga ◽  
Louise Hannallah ◽  
Sara E. Field ◽  
Merel Kozlosky ◽  
...  
Keyword(s):  
At Risk ◽  
Eating Disorder ◽  
Weight Gain ◽  
Binge Eating ◽  
Eating Behavior ◽  
Adolescent Girls ◽  
Binge Eating Disorder ◽  
Efficacy Beliefs ◽  
Excess Weight ◽  
Excess Weight Gain

Feeding and Eating Disorders

2017 ◽  
Author(s):  
Patricia Westmoreland ◽  
Phillip S Mehler
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Food Intake ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Restrictive Eating ◽  
Dsm 5 ◽  
Feeding And Eating Disorders

Feeding and eating disorders are defined by persistent disturbance of eating (or behaviors related to eating) with subsequent changes in consumption or absorption of nutrition that are detrimental to physical health and social functioning. The following eating disorders are described in the DSM-5: anorexia nervosa, bulimia nervosa, binge eating disorder, pica, rumination disorder, avoidant/restrictive food intake disorder (ARFID), other specified feeding or eating disorder (OSFED), and unspecified feeding or eating disorder (USFED). ARFID, OSFED, USFED, rumination disorder, and binge eating disorder are new additions to the manual and are first described in the DSM-5. The DSM-5 also provides severity specifiers—mild, moderate, severe, and extreme—for the diagnoses of bulimia nervosa and anorexia nervosa. This review describes the eating disorders enumerated in the DSM-5 and provides information regarding their genesis and course. This review contains 8 tables and 79 references Key words: avoidant/restrictive eating disorder, binge eating disorder, DSM-5, eating disorder, other specified feeding or eating disorder, pharmacotherapy, pica rumination, psychotherapy, unspecified feeding or eating disorder

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