scholarly journals An Improvement of Cardiovascular Risk Factors by Omega-3 Polyunsaturated Fatty Acids

2018 ◽  
Vol 10 (4) ◽  
pp. 281-289 ◽  
Author(s):  
Hidekatsu Yanai ◽  
Yoshinori Masui ◽  
Hisayuki Katsuyama ◽  
Hiroki Adachi ◽  
Akiko Kawaguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Polyunsaturated Fatty Acids ◽  
Cardiovascular Risk Factors ◽  
Omega 3

scholarly journals Leukocyte telomere length and serum polyunsaturated fatty acids, dietary habits, cardiovascular risk factors and features of myocardial infarction in elderly patients

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Are A. Kalstad ◽  
Sjur Tveit ◽  
Peder L. Myhre ◽  
Kristian Laake ◽  
Trine B. Opstad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Linoleic Acid ◽  
Elderly Patients ◽  
Polyunsaturated Fatty Acids ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Omega 3

Abstract Background Telomeres are non-coding sequences at the end of eukaryote chromosomes, which in complex with associated proteins serve to protect subtelomeric DNA. Telomeres shorten with each cell division, are regarded as a biomarker for aging and have also been suggested to play a role in atherosclerosis and cardiovascular disease (CVD). The aim of the present study was to explore the associations between leukocyte telomere length and serum polyunsaturated fatty acids, diet, cardiovascular risk factors and features of myocardial infarction (MI) in elderly patients. Methods The material is based upon the first 299 included patients in the OMEMI trial, where patients aged 70–82 years of age are randomized to receive omega-3 supplements or corn oil (placebo) after MI. Patients were included 2–8 weeks after the index MI. DNA was extracted from whole blood, and leukocyte telomere length (LTL) was analyzed by qPCR and reported as a number relative to a reference gene. Serum long chain polyunsaturated fatty acid (LCPUFA) content was analyzed by gas chromatography. Diet was evaluated with the validated SmartDiet food frequency questionnaire. Medical records, patient interviews and clinical examination provided previous medical history and anthropometric data. Non-parametric statistical tests were used. Results Median (25, 75 percentile) LTL was 0.55 (0.42, 0.72). Patients had a median age of 75 years, 70.2% were male and 45.2% used omega-3 supplements. There was a weak, but significant correlation between LTL and linoleic acid (r = 0.139, p = 0.017), but not with other LCPUFAs. There was a trend towards longer telomeres with a healthier diet, but this did not reach statistical significance (p = 0.073). No associations were found between LTL and CVD risk factors or features of MI. Conclusions In our population of elderly with a recent myocardial infarction LTL was associated with linoleic acid concentrations, but not with other LCPUFAs. Patients with a healthy diet tended to have longer telomeres. The limited associations may be due to age and the narrow age-span in our population. Further studies, designed to detect longitudinal changes should be performed to explore the role of telomeres in cardiovascular aging. Trial registration Clinical trials no. NCT01841944, registration date April 29, 2013.

Major depression, cardiovascular risk factors and the Omega-3 index

2011 ◽  
Vol 26 (S2) ◽  
pp. 603-603 ◽  
Author(s):  
T.C. Baghai ◽  
G. Varallo-Bedarida ◽  
C. Born ◽  
S. Haefner ◽  
C. Schüle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Depressive Disorders ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Major Depressive Disorders ◽  
High Concentrations ◽  
Conventional Risk Factors

IntroductionCardiovascular disease (CVD) and major depressive disorders (MDD) are frequent diseases worldwide with a high comorbidity rate. Omega-3 fatty acids have been suggested as disease modulators for both CVD and MDD.Objective and aimsTherefore, we studied whether polyunsaturated fatty acids and the Omega-3 Index may represent markers for assessment of the cardiovascular risk in physically healthy patients suffering from MDD.MethodsCase-control study in 166 adults (86 MDD patients without CVD, 80 matched healthy controls). Baseline examinations included depression ratings, conventional cardiovascular risk factors, fatty acid, and interleukin-6 determinations.ResultsSeveral conventional risk factors were more prevalent in MDD patients. The Omega-3 Index and individual omega-3 fatty acids were significantly lower in MDD patients. An Omega-3 Index < 4% was associated with high concentrations of the proinflammatory cytokine IL-6.ConclusionConventional cardiovascular risk factors, the Omega-3 Index and IL-6 indicated an elevated cardiovascular risk profile in MDD patients currently free of CVD. Our results support the employment of strategies to reduce the cardiovascular risk in yet cardiovascularly healthy MDD patients by targeting conventional risk factors and the Omega-3 Index.

Cardiovascular Risk Factors and Dietary Plant Omega-3 Verus Omega-6 Fatty Acids

1996 ◽  
Vol 96 (9) ◽  
pp. A75
Author(s):  
M.A. Allman ◽  
D. Pang ◽  
K.M. Kingham ◽  
D.F. Hall ◽  
E. Favaloro
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Omega 3 ◽  
Omega 6

scholarly journals Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD

2011 ◽  
Vol 106 (3) ◽  
pp. 425-431 ◽  
Author(s):  
Aleix Sala-Vila ◽  
William S. Harris ◽  
Montserrat Cofán ◽  
Ana M. Pérez-Heras ◽  
Xavier Pintó ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Dietary Fatty Acids ◽  
Mediterranean Population ◽  
Omega 3 ◽  
High Background ◽  
Increased Risk ◽  
The Impact

The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA+DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA+DHA was 0·9 g/d and the mean omega-3 index was 7·1 %. In multivariate models, EPA+DHA intake was the main predictor of the omega-3 index but explained only 12 % of its variability (P < 0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA+DHA, it explained little of the former's variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.

scholarly journals Effects of n-3 Polyunsaturated Fatty Acids (ω-3) Supplementation on Some Cardiovascular Risk Factors with a Ketogenic Mediterranean Diet

Marine Drugs ◽  
2015 ◽  
Vol 13 (2) ◽  
pp. 996-1009 ◽  
Author(s):  
Antonio Paoli ◽  
Tatiana Moro ◽  
Gerardo Bosco ◽  
Antonino Bianco ◽  
Keith Grimaldi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Polyunsaturated Fatty Acids ◽  
Cardiovascular Risk Factors ◽  
Mediterranean Diet
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