scholarly journals Recombinase Activating Gene 1 Deficiencies Without Omenn Syndrome May Also Present With Eosinophilia and Bone Marrow Fibrosis

2016 ◽  
Vol 8 (5) ◽  
pp. 379-384 ◽  
Author(s):  
Ezgi Ulusoy ◽  
Neslihan Edeer Karaca ◽  
Elif Azarsiz ◽  
Afig Berdeli ◽  
Guzide Aksu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Omenn Syndrome ◽  
Bone Marrow Fibrosis ◽  
Marrow Fibrosis

scholarly journals Prolonged Myelosuppression due to Progressive Bone Marrow Fibrosis in a Patient with Acute Promyelocytic Leukemia

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Yuta Inagawa ◽  
Yukiko Komeno ◽  
Satoshi Saito ◽  
Yuji Maenohara ◽  
Tetsuro Yamagishi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Promyelocytic Leukemia ◽  
Bone Marrow Biopsy ◽  
Gastric Fluid ◽  
Promyelocytic Leukemia ◽  
Consolidation Therapy ◽  
Bone Marrow Fibrosis ◽  
All Trans Retinoic Acid ◽  
Phlegmonous Gastritis ◽  
Marrow Fibrosis

A 34-year-old woman was diagnosed with acute promyelocytic leukemia. Chemotherapy was administered following the JALSG APL204 protocol. Induction therapy with all-trans retinoic acid resulted in complete remission on day 49. She developed coccygeal pain from day 18, which spread to the spine and cheekbones and lasted 5 weeks. She had similar bone pain on days 7–10 of the first consolidation therapy and on days 4–12 of the second consolidation therapy. Oral loxoprofen was prescribed for pain relief. On day 33 of the third consolidation, white blood cell and neutrophil counts were 320/μL and 20/μL, respectively. After she developed epigastralgia and hematemesis, she developed septic shock. Gastroendoscopy revealed markedly thickened folds and diffusely damaged mucosa with blood oozing. Computed tomography revealed thickened walls of the antrum and the pylorus. Despite emergency treatments, she died. Bacterial culture of the gastric fluid yielded Enterobacter cloacae and enterococci growth. Collectively, she was diagnosed with phlegmonous gastritis. Retrospective examination of serial bone marrow biopsy specimens demonstrated progressive bone marrow fibrosis, which may have caused prolonged myelosuppression. Thus, evaluation of bone marrow fibrosis by bone marrow biopsy after each treatment cycle might serve as a predictor of persistent myelosuppression induced by chemotherapy.

scholarly journals Lung fibrosis, bone marrow fibrosis and liver cirrhosis: A Short Telomere Syndrome or a casual association?

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Lucia Carulli ◽  
Claudia Anzivino ◽  
Marco Bertolotti ◽  
Paola Loria ◽  
Luca Richeldi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Cirrhosis ◽  
Lung Fibrosis ◽  
Short Telomere ◽  
Bone Marrow Fibrosis ◽  
Marrow Fibrosis

scholarly journals Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis, splenomegaly and with a shorter median time to disease progression

Oncotarget ◽  
2017 ◽  
Vol 8 (61) ◽  
pp. 103274-103282 ◽  
Author(s):  
Kseniya Petrova-Drus ◽  
April Chiu ◽  
Elizabeth Margolskee ◽  
Sharon Barouk-Fox ◽  
Julia Geyer ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Disease Progression ◽  
Median Time ◽  
Chronic Myelomonocytic Leukemia ◽  
Bone Marrow Fibrosis ◽  
Myelomonocytic Leukemia ◽  
Marrow Fibrosis

scholarly journals Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azar

2000 ◽  
Vol 33 (4) ◽  
pp. 363-366 ◽  
Author(s):  
Francisco Dário Rocha Filho ◽  
Francisco Valdeci de Almeida Ferreira ◽  
Flávia de Oliveira Mendes ◽  
Fernanda Nogueira Holanda Ferreira ◽  
Alexandre Karbage ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Iliac Crest ◽  
Histological Analysis ◽  
Blood Parameters ◽  
Bone Marrow Fibrosis ◽  
Iliac Crest Biopsy ◽  
The Third ◽  
Kala Azar ◽  
Reticulin Fibers ◽  
Marrow Fibrosis

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly.Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.

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