scholarly journals Novel Translocation in Acute Myeloid Leukemia: Case Report and Review of Risk-Stratification and Induction Chemotherapy in Patients With Acute Myeloid Leukemia

2020 ◽  
Vol 9 (1-2) ◽  
pp. 13-17 ◽  
Author(s):  
George M. Jeha ◽  
Tiffany Wesley ◽  
Vince D. Cataldo
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Risk Stratification ◽  
Induction Chemotherapy ◽  
Myeloid Leukemia ◽  
Acute Myeloid Leukemia Case ◽  
Acute Myeloid

Idiopathic hyperammonemia (IHA) after dose-dense induction chemotherapy for acute myeloid leukemia: Case report and review of the literature

2009 ◽  
Vol 33 (7) ◽  
pp. e69-e72 ◽  
Author(s):  
Klaus H. Metzeler ◽  
Stefan Boeck ◽  
Birgit Christ ◽  
Andreas Hausmann ◽  
Hans-Joachim Stemmler ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Induction Chemotherapy ◽  
Myeloid Leukemia ◽  
Review Of The Literature ◽  
Acute Myeloid Leukemia Case ◽  
Dose Dense ◽  
Acute Myeloid

scholarly journals Sweet's syndrome during induction chemotherapy for acute myeloid leukemia – case report and mini review

2020 ◽  
Author(s):  
Gabriela Spacek da Fonseca ◽  
Ana Flávia Dinardi Alves Pinto ◽  
Sândala Cristina Fernandes Silveira ◽  
João Henrique do Amaral e Silva ◽  
Vanessa Afonso da Silva ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Induction Chemotherapy ◽  
Myeloid Leukemia ◽  
Sweet’S Syndrome ◽  
Sweet's Syndrome ◽  
Acute Myeloid Leukemia Case ◽  
Acute Myeloid

Validation of Monosomal Karyotype Based Model In the Risk Stratification of Acute Myeloid Leukemia

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 2745-2745
Author(s):  
Murtadha K. Al-Khabori ◽  
Karen Yee ◽  
Vikas Gupta ◽  
Aaron Schimmer ◽  
Andre Schuh ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Risk Stratification ◽  
Induction Chemotherapy ◽  
Myeloid Leukemia ◽  
Conflicts Of Interest ◽  
Structural Abnormality ◽  
Complex Karyotype ◽  
Poor Risk ◽  
Monosomal Karyotype ◽  
Acute Myeloid

Abstract Abstract 2745 Background: The influence of cytogenetic abnormalities on the prognosis of acute myeloid leukemia (AML) has been well-documented; however, the relative impact of certain miscellaneous abnormalities remains controversial. Recently, monosomal karyotype-based risk stratification has been shown to further discriminate the prognosis within the poor-risk karyotype group (Breems et al. JCO 2008), but this finding requires further validation. Methods: We retrospectively reviewed 779 consecutive adult AML patients treated with standard induction chemotherapy, consisting of daunorubicin plus cytarabine (3+7), at our institution from 1998–2008. After excluding patients with favourable risk, normal, missing or failed karyotype, 290 patients remained and were included in the analysis. Results: The baseline characteristics of these 290 patients were as follows: median age 59 y (range 18–81), male 181, prior malignancy 110, median white cell count (WBC) 7.6 × 10^9/L (range 0–246). The karyotypic features included single monosomy in 42, 2 or more monosomies in 51, and non-monosomy structural and numerical abnormalities in 197 patients. Of the 290, 116 (40 %) had three or more abnormalities (complex karyotype, CK). A total of 141 patients (49 %) achieved complete remission (CR) with 3+7 induction chemotherapy. Sixty-four patients received allogeneic stem cell transplantation in CR. The median overall survival (OS) for all patients was 12 months (95% CI: 10–14 months). The median OS was 10 (95% CI: 6–18), 7 (95% CI: 6–10) and 14 months (95% CI: 12–16) in the single monosomy, 2+ monosomy and non-monosomy groups, respectively (p < 0.0001 by log-rank test comparing the three groups). Among the patients containing at least one monosomy, the OS was not significantly different between the CK and non-CK groups (p = 0.08 by log rank). Similarly, in the non-monosomy structural abnormality group, the OS was not significantly different between the CK and non-CK groups (p = 0.2). Conclusions: Our results provide validation for the monosomal karyotype-based risk stratification for AML, indicating that patients with at least one monosomy have an inferior OS compared to other poor-risk non-monosomy groups. Within each of the monosomy and non-monosomy groups, the presence of a complex karyotype does not significantly influence the OS. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Anterior myeloid sarcoma revealing acute myeloid leukemia: Case report

2016 ◽  
Vol 65 (3) ◽  
pp. 729-732
Author(s):  
H. Slimani ◽  
L. Achaachi ◽  
Y. Benbaba ◽  
L. Herrak ◽  
K. Znati ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
Myeloid Sarcoma ◽  
Acute Myeloid Leukemia Case ◽  
Acute Myeloid
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