scholarly journals Teriparatide Prevented Near Atypical Femur Fracture by Reducing Cortical Thickening in a Symptomatic Patient With Prolonged Use of Oral Bisphosphonate: A Case Report

2016 ◽  
Vol 6 (6) ◽  
pp. 183-186
Author(s):  
Jaspinder Kaur ◽  
Luis Chavez ◽  
Issac Sachmechi ◽  
Paul Kim
Keyword(s):  
Case Report ◽  
Femur Fracture ◽  
Symptomatic Patient ◽  
Cortical Thickening ◽  
Atypical Femur Fracture ◽  
Oral Bisphosphonate

scholarly journals Risk of complete atypical femur fracture with Oral bisphosphonate exposure beyond three years

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Joan C. Lo ◽  
Romain S. Neugebauer ◽  
Bruce Ettinger ◽  
Malini Chandra ◽  
Rita L. Hui ◽  
...  
Keyword(s):  
Cumulative Incidence ◽  
Femur Fracture ◽  
Demographic Data ◽  
Large Population ◽  
Risk Difference ◽  
Atypical Femur Fracture ◽  
Oral Bisphosphonate ◽  
Increased Risk ◽  
Incidence Risk ◽  
Fracture History

Abstract Background Bisphosphonate (BP) therapy has been associated with atypical femur fracture (AFF). However, the threshold of treatment duration leading to increased AFF risk is unclear. In a retrospective cohort of older women initiating BP, we compared the AFF risk associated with treatment for at least three years to the risk associated with treatment less than three years. Methods We used observational data from a large population of female members of an integrated healthcare system who initiated oral BP during 2002–2014. Women were retrospectively followed for incident AFF confirmed by radiologic adjudication. Demographic data, pharmacologic exposures, comorbidity, bone density, and fracture history were ascertained from electronic health records. Inverse probability weighting was used to estimate risk differences comparing the cumulative incidence (risk) of AFF if women discontinued BP within three years to the cumulative incidence of AFF if women continued BP for three or more years, adjusting for potential time-dependent confounding by the aforementioned factors. Results Among 87,820 women age 45–84 years who initiated BP (mean age 68.6, median T-score − 2.6, 14% with prior major osteoporotic fracture), 16,180 continued BP for three or more years. Forty-six confirmed AFFs occurred during follow-up in the two groups. AFF-free survival was greater for BP treatment < 3 years compared to treatment ≥3 years (p = 0.004 comparing areas under survival curves). At five years, the risk of AFF was 27 per 100,000 (95% confidence interval, CI: 8–46) if women received BP treatment < 3 years and 120 per 100,000 (95% CI: 56–183) if women received BP treatment ≥3 years (risk difference 93 per 100,000, 95% CI: 30–160). By ten years, the risks were 27 (95% CI: 8–46) and 363 (95% CI: 132–593) per 100,000 for BP treatment < 3 and ≥ 3 years, respectively (risk difference 336 per 100,000, 95% CI: 110–570). Conclusions Bisphosphonate treatment for 3 or more years was associated with greater risk of AFF than treatment for less than 3 years. Although AFFs are uncommon among BP-treated women, this increased risk should be considered when counseling women about long-term BP use. Future studies should further characterize the dose-response relationship between BP duration and incident AFF and identify patients at highest risk.

scholarly journals Atraumatic segmental atypical femur fracture secondary to bisphosphonate use: A case report

2017 ◽  
Vol 8 ◽  
pp. S67-S71 ◽  
Author(s):  
Andrew J. Lovy ◽  
Diana Patterson ◽  
Laura Skeeles ◽  
Richard Ghillani ◽  
David Joseph ◽  
...  
Keyword(s):  
Case Report ◽  
Femur Fracture ◽  
Atypical Femur Fracture

scholarly journals The association of race/ethnicity and risk of atypical femur fracture among older women receiving oral bisphosphonate therapy

Bone ◽  
2016 ◽  
Vol 85 ◽  
pp. 142-147 ◽  
Author(s):  
Joan C. Lo ◽  
Rita L. Hui ◽  
Christopher D. Grimsrud ◽  
Malini Chandra ◽  
Romain S. Neugebauer ◽  
...  
Keyword(s):  
Older Women ◽  
Femur Fracture ◽  
Bisphosphonate Therapy ◽  
Atypical Femur Fracture ◽  
Oral Bisphosphonate ◽  
Race Ethnicity

scholarly journals A case of atypical femur fracture during long-term treatment with bisphosphonates in patient with postmenopausal osteoporosis

2019 ◽  
Vol 22 (1) ◽  
pp. 18-23
Author(s):  
Kira E. Zotkina ◽  
Olga M. Lesnyak ◽  
Aleksandr Yu. Kochish ◽  
Ivan V. Sushkov
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Femur Fracture ◽  
Term Treatment ◽  
Atypical Femur Fracture ◽  
First Line Therapy ◽  
Oral Bisphosphonate ◽  
Long Term Treatment ◽  
Rare Side Effect ◽  
The Right

Bisphosphonates is a first-line therapy for treatment of osteoporosis. In the last decade, the number of atypical femur fracture (AFF) cases during long-term treatment with bisphosphonates has increased. The aim of this article was to analyze the literature data on this problem, to define the diagnostic criteria of AFF and to present the case of AFF in the patient who received treatment with alendronate for 3.5 years. A 78-year-old woman, receiving oral bisphosphonate for severe postmenopausal osteoporosis for 3.5 years, suddenly started feeling pain in her right thigh while walking. Three months later, she had got a fracture in middle third of the right femur after falling from her standing height. According to instrumental diagnostics, this fracture had all criteria of AFF. Blocking intramedullary osteosynthesis with shafts was performed. A retrospective analysis of soft tissue magnetic resonance imaging in the area of right thigh, done before the fracture, showed the presence of undiagnosed incomplete right femur fracture in the middle third, which subsequently led to a complete fracture. Presented clinical case demonstrates the complexity of AFF diagnostics. The purpose of the publication is to draw attention of medical specialists to the issue of this rare side effect of bisphosphonate treatment.

scholarly journals A case report of pycnodysostosis with atypical femur fracture diagnosed by next-generation sequencing of candidate genes

Medicine ◽  
2017 ◽  
Vol 96 (12) ◽  
pp. e6367 ◽  
Author(s):  
Hyung Keun Song ◽  
Young Bae Sohn ◽  
Yong Jun Choi ◽  
Yoon-Sok Chung ◽  
Ja-Hyun Jang
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Candidate Genes ◽  
Femur Fracture ◽  
Next Generation ◽  
Atypical Femur Fracture ◽  
Generation Sequencing

scholarly journals Full Thickness Tear of Quadriceps Tendon Associated with Closed Intra-Articular Distal Femur Fracture: A Case Report

2021 ◽  
pp. 131-137
Author(s):  
Santanu Kar ◽  
Hemant Bansal ◽  
Vijay Sharma ◽  
Kamran Farooque
Keyword(s):  
Case Report ◽  
Distal Femur ◽  
Femur Fracture ◽  
Femoral Fractures ◽  
Quadriceps Tendon ◽  
Successful Outcome ◽  
Postoperative Rehabilitation ◽  
Present Case Report ◽  
Distal Femur Fracture ◽  
Rare Association

Fractures of the supracondylar and intercondylar region of the distal femur usually result from high velocity injury that is uncommonly associated with violation of the integrity of the extensor mechanism. The consequences of missed quadriceps injury associated with a distal femur fracture are devastating. The present case report illustrates the importance of recognizing the rare association of quadriceps tear with distal femoral fractures, an appropriate surgical approach to repair the tear as well as fixation of fracture, and a protocol of postoperative rehabilitation to achieve a successful outcome.

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