scholarly journals A Rare Case of Transformation of Endometrial Carcinoma Into Uterine Carcinosarcoma

2021 ◽  
Vol 10 (3) ◽  
pp. 81-85
Author(s):  
Leela Sharath Pillarisetty ◽  
Srikanth Mukkera ◽  
Maneesh Mannem ◽  
Jinal Patel ◽  
Subash Nagalla ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Rare Case ◽  
Uterine Carcinosarcoma

Uterine Carcinosarcoma in A Postmenopausal Woman: A Rare Case Report

2018 ◽  
Vol 16 (4) ◽  
Author(s):  
Anjili Kumari ◽  
Sangeeta Pankaj ◽  
Jaya Kumari ◽  
Anita Kumari ◽  
Syed Nazneen ◽  
...  
Keyword(s):  
Case Report ◽  
Postmenopausal Woman ◽  
Rare Case ◽  
Uterine Carcinosarcoma ◽  
Rare Case Report

Recurrent early stage endometrial carcinoma presenting as vaginal and colonic metastasis: A rare case report

2019 ◽  
Vol 6 (1) ◽  
pp. 113-115
Author(s):  
Nitesh R. Maurya ◽  
◽  
Urvi C. Bhavsar ◽  
Sushrut A. Bhukte ◽  
Vijayshree S. Patil ◽  
...  
Keyword(s):  
Case Report ◽  
Endometrial Carcinoma ◽  
Rare Case ◽  
Early Stage ◽  
Colonic Metastasis ◽  
Rare Case Report

scholarly journals Experimental and Meta-Analytic Validation of RNA Sequencing Signatures for Predicting Status of Microsatellite Instability

2021 ◽  
Vol 8 ◽  
Author(s):  
Maksim Sorokin ◽  
Elizaveta Rabushko ◽  
Victor Efimov ◽  
Elena Poddubskaya ◽  
Marina Sekacheva ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Esophageal Cancer ◽  
Microsatellite Instability ◽  
Endometrial Carcinoma ◽  
Rna Sequencing ◽  
Wide Spectrum ◽  
The Cancer Genome Atlas ◽  
Laboratory Diagnostics ◽  
Reaction Products ◽  
Uterine Carcinosarcoma

Microsatellite instability (MSI) is an important diagnostic and prognostic cancer biomarker. In colorectal, cervical, ovarian, and gastric cancers, it can guide the prescription of chemotherapy and immunotherapy. In laboratory diagnostics of susceptible tumors, MSI is routinely detected by the size of marker polymerase chain reaction products encompassing frequent microsatellite expansion regions. Alternatively, MSI status is screened indirectly by immunohistochemical interrogation of microsatellite binding proteins. RNA sequencing (RNAseq) profiling is an emerging source of data for a wide spectrum of cancer biomarkers. Recently, three RNAseq-based gene signatures were deduced for establishing MSI status in tumor samples. They had 25, 15, and 14 gene products with only one common gene. However, they were developed and tested on the incomplete literature of The Cancer Genome Atlas (TCGA) sampling and never validated experimentally on independent RNAseq samples. In this study, we, for the first time, systematically validated these three RNAseq MSI signatures on the literature colorectal cancer (CRC) (n = 619), endometrial carcinoma (n = 533), gastric cancer (n = 380), uterine carcinosarcoma (n = 55), and esophageal cancer (n = 83) samples and on the set of experimental CRC RNAseq samples (n = 23) for tumors with known MSI status. We found that all three signatures performed well with area under the curve (AUC) ranges of 0.94–1 for the experimental CRCs and 0.94–1 for the TCGA CRC, esophageal cancer, and uterine carcinosarcoma samples. However, for the TCGA endometrial carcinoma and gastric cancer samples, only two signatures were effective with AUC 0.91–0.97, whereas the third signature showed a significantly lower AUC of 0.69–0.88. Software for calculating these MSI signatures using RNAseq data is included.

Expression of p27 and p53: comparative analysis of uterine carcinosarcoma and endometrial carcinoma

2004 ◽  
Vol 14 (2) ◽  
pp. 354-359 ◽  
Author(s):  
A. Abargel ◽  
I. Avinoach ◽  
V. Kravtsov ◽  
M. Boaz ◽  
M. Glezerman ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Immunohistochemical Staining ◽  
Endometrioid Carcinoma ◽  
Uterine Carcinosarcoma ◽  
Clinical Value ◽  
P53 Overexpression ◽  
P53 Expression ◽  
Epithelial Component ◽  
Endometrial Carcinomas ◽  
Epithelial Element

The aim of the study was to assess both p27 and p53 expression in the stromal and epithelial component of carcinosarcoma and to assess if their expression in the latter is different than in endometrial carcinoma. Immunohistochemical staining for p27 and p53 was performed on paraffin-embedded tissue blocks of 18 uterine specimens with carcinosarcoma and their expression assessed. Their expression in the epithelial element was also compared to that in 35 paraffin-embedded tissue blocks of endometrial endometrioid carcinoma.Reduced p27 expression was observed in a similarly high proportion of the stromal (77.8%) as well as of the epithelial component (66.7%) of carcinosarcoma. Although statistically not significant, the proportion of reduced p27 expression in endometrial carcinoma (85.7%) was higher than in the epithelial element of carcinosarcoma.The percentage of p53 overexpression in both elements of carcinosarcomas and in endometrial carcinomas was low and also similar (27.8 and 20.0%, respectively).Our results indicate that reduced p27 expression is common and p53 overexpression is infrequent in carcinosarcoma. Their similar rates of expression in the stromal and epithelial elements of the tumor support the contention of a monoclonal origin of carcinosarcoma. Unexpectedly, reduced p27 expression is more common in endometrial carcinoma than in the epithelial element of carcinosarcoma, in spite of the less favorable prognosticators and outcome in the latter.Further studies of p27 expression in carcinosarcoma are indicated to establish its clinical value in this aggressive malignancy.

scholarly journals Thyroid Gland Metastasis From Endometrial Carcinoma Causing Acute Severe Dyspnea

2021 ◽  
pp. 014556132110455
Author(s):  
Fabio Bertone ◽  
Elena Serusi ◽  
Daniel S. Liscia ◽  
Elena Biletta ◽  
Carmine F. Gervasio
Keyword(s):  
Thyroid Gland ◽  
Endometrial Carcinoma ◽  
Rare Disease ◽  
Multidisciplinary Team ◽  
Emergency Surgery ◽  
Rare Case ◽  
Endometrioid Adenocarcinoma ◽  
Thyroid Metastasis ◽  
Cervical Carcinomas ◽  
Thyroid Metastases

Thyroid metastasis from cervical carcinomas is an extremely rare disease; therefore, only a few cases have so far been reported in the literature. Due to the lack of data and the heterogeneity of clinical cases, the percentage of patients affected by thyroid metastases eligible to undergo surgery is not easily predictable. This report describes a rare case of endometrioid adenocarcinoma metastasized to the thyroid gland. A 72-year-old woman was referred to the ENT department of our hospital (Ospedale Degli Infermi di Biella, Italy) presenting with dyspnea and rapidly worsening condition, in need of emergency surgery. The peculiarity of this case lies in the metastasis isotype rarity, in its voluminous dimension, and in its mediastinal localization, which required the intervention of a multidisciplinary team to establish successful treatment planning.

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