scholarly journals Interrelation of galectin-3 and circulating proangiogenic endothelial cells in patients with ischemic chronic heart failure

Pathologia ◽  
2014 ◽  
Vol 0 (2) ◽  
Author(s):  
A. A. Kremzer
Keyword(s):  
Heart Failure ◽  
Endothelial Cells ◽  
Chronic Heart Failure ◽  
Galectin 3

scholarly journals Galectin-3 as a marker and mediator of endogenous inflammation and nitrosylation oxidative stress in patients with chronic heart failure

2013 ◽  
pp. 45-49 ◽  
Author(s):  
Yu. B. Shchukin ◽  
I. I. Berezin ◽  
E. A. Medvedeva ◽  
E. I. Seleznev ◽  
V. A. Dyachkov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Galectin 3

scholarly journals Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells

2016 ◽  
Vol 38 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Shang Wang ◽  
Chao-liang Long ◽  
Jun Chen ◽  
Wen-yu Cui ◽  
Yan-fang Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Endothelial Cells ◽  
Chronic Heart Failure ◽  
Therapeutic Approach

scholarly journals Role of galectin-3 and plasma B type-natriuretic peptide in predicting prognosis in discharged chronic heart failure patients

Medicine ◽  
2016 ◽  
Vol 95 (26) ◽  
pp. e4014 ◽  
Author(s):  
Mauro Feola ◽  
Marzia Testa ◽  
Laura Leto ◽  
Marco Cardone ◽  
Mario Sola ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Natriuretic Peptide ◽  
Heart Failure Patients ◽  
Galectin 3

scholarly journals Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 24 (2) ◽  
pp. E327-E332
Author(s):  
Chenxia Wu ◽  
Zhengtian Lv ◽  
Xinyi Li ◽  
Xinbing Zhou ◽  
Wei Mao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Chronic Heart Failure ◽  
Cardiac Fibrosis ◽  
Inflammatory Marker ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Heart Failure Patients ◽  
Galectin 3 ◽  
The Cochrane Library

Background: In recent years, galectin-3, an inflammatory marker, has been demonstrated to be closely related to cardiac fibrosis and heart failure. The purpose of this systematic review and meta-analysis is to define galectin-3 in predicting mortality of heart failure. Methods: PubMed, Embase, and the Cochrane Library were searched. A total of 1540 studies were identified, and of these studies, 19 involving 9217 patients were included in our meta-analysis. Results: The diagnostic hazard ratios of galectin-3 in predicting mortality in chronic heart failure patients was 1.13 (95% CI,:1.07-1.21 ) and 2.17 (95% CI:1.27-3.08) in acute heart failure (HF) patients. Conclusions: Our meta-analysis shows that elevated levels of galectin-3 are associated with higher mortality in both acute and chronic heart failure patients.

scholarly journals Galectin-3 serum levels are independently associated with microalbuminuria in chronic heart failure outpatients

2016 ◽  
Vol 5 (1) ◽  
pp. 12 ◽  
Author(s):  
Massimo Iacoviello ◽  
Nadia Aspromonte ◽  
Marta Leone ◽  
Valeria Paradies ◽  
Valeria Antoncecchi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Serum Levels ◽  
Galectin 3

scholarly journals CLINICAL VALUE OF BLOOD BIOMARKERS IN PATIENTS WITH CHRONIC HEART FAILURE

2018 ◽  
Vol 8 (5) ◽  
pp. 333-345
Author(s):  
A. M. Aliyeva ◽  
E. V. Reznik ◽  
E. T. Hasanova ◽  
I. V. Zhbanov ◽  
I. G. Nikitin
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Arginine Vasopressin ◽  
Functional Class ◽  
The Body ◽  
Protective Effects ◽  
Clinical Value ◽  
Soluble St2 ◽  
Galectin 3 ◽  
St2 Receptor

Biomarkers (various laboratory biochemical markers), such as natriuretic peptides (NP), soluble ST2 receptor, copeptin, galectin-3, are widely studied in patients with chronic heart failure (CHF). The European Society of Cardiology recommends the determination of blood NP level in suspicion of HF and its use as one of the mandatory diagnostic criteria for CHF with preserved and mid-range ejection fraction. Dynamics of NP concentration may be predictor of the effectiveness of the therapy and the necessity of the titration of the dose of HF drugs. Neprilyzin destroys NP, but does not destroy their precursors, including NT-proBNP. Therefore, it is necessary to use NT-proBNP as a marker of therapeutic efficacy and prognosis when using neprilysine inhibitors (sacubitril). ST2 is a protein receptor for interleukin-33 (IL-33). The transmembrane ST2 (ST2L) binds to IL-33 and forms the IL-33/ST2L complex, which has a cardioprotective effect, prevents the development of myocardial hypertrophy, fibrosis and apoptosis. The soluble ST2 receptor (sST2) is a “trap” for IL-33 and neutralizes the protective effects of the IL-33/ST2L complex, which leads to hypertrophy and fibrosis of the myocardium, dilatation of the chambers and reduction of the contractility of the heart. It can be considered as a marker of unfavorable prognosis in heart failure, but it is not specific. Copeptin is a part of the arginine-vasopressin, or antidiuretic hormone, precursor which plays an important role in the pathogenesis of CHF. Since arginine-vasopressin has a short half-life and is unstable outside the body, copeptin is being actively investigated. Its level increases during the CHF decompensation and relates with the functional class of CHF. A combined measurement of the concentration of copeptin and NP may improve the risk stratification in CHF patients. Galectin-3 is a peptide that stimulates the activation of fibroblasts and the development of fibrosis. It increases in CHF patients and is associated with the severity of the condition, systolic and diastolic LV dysfunction and prognosis. Currently, NP are the best biomarkers that can and should be used in routine clinical practice. To prove the need for widespread use of other biomarkers, additional research is needed.

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