scholarly journals Research and progress of cartilage tissue-engineering scaffold materials

2015 ◽  
Vol 2 (3) ◽  
pp. 51
Author(s):  
Hongli Zhai ◽  
Yuchi Wu
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Tissue Engineering Scaffold ◽  
Cartilage Tissue ◽  
Scaffold Materials

Cellulose-based scaffold materials for cartilage tissue engineering

Biomaterials ◽  
2006 ◽  
Vol 27 (21) ◽  
pp. 3955-3963 ◽  
Author(s):  
Frank A. Müller ◽  
Lenka Müller ◽  
Ingo Hofmann ◽  
Peter Greil ◽  
Magdalene M. Wenzel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Scaffold Materials

scholarly journals Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Xia Zhao ◽  
Daniel A. Hu ◽  
Di Wu ◽  
Fang He ◽  
Hao Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Articular Chondrocytes ◽  
Critical Role ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
3D Bioprinting ◽  
Repair Capacity ◽  
Scaffold Materials

Cartilage, especially articular cartilage, is a unique connective tissue consisting of chondrocytes and cartilage matrix that covers the surface of joints. It plays a critical role in maintaining joint durability and mobility by providing nearly frictionless articulation for mechanical load transmission between joints. Damage to the articular cartilage frequently results from sport-related injuries, systemic diseases, degeneration, trauma, or tumors. Failure to treat impaired cartilage may lead to osteoarthritis, affecting more than 25% of the adult population globally. Articular cartilage has a very low intrinsic self-repair capacity due to the limited proliferative ability of adult chondrocytes, lack of vascularization and innervation, slow matrix turnover, and low supply of progenitor cells. Furthermore, articular chondrocytes are encapsulated in low-nutrient, low-oxygen environment. While cartilage restoration techniques such as osteochondral transplantation, autologous chondrocyte implantation (ACI), and microfracture have been used to repair certain cartilage defects, the clinical outcomes are often mixed and undesirable. Cartilage tissue engineering (CTE) may hold promise to facilitate cartilage repair. Ideally, the prerequisites for successful CTE should include the use of effective chondrogenic factors, an ample supply of chondrogenic progenitors, and the employment of cell-friendly, biocompatible scaffold materials. Significant progress has been made on the above three fronts in past decade, which has been further facilitated by the advent of 3D bio-printing. In this review, we briefly discuss potential sources of chondrogenic progenitors. We then primarily focus on currently available chondrocyte-friendly scaffold materials, along with 3D bioprinting techniques, for their potential roles in effective CTE. It is hoped that this review will serve as a primer to bring cartilage biologists, synthetic chemists, biomechanical engineers, and 3D-bioprinting technologists together to expedite CTE process for eventual clinical applications.

Gas-Electrospun Degradable PEG/PBT-HA: Potential Scaffold for Tissue Engineering

2011 ◽  
Vol 284-286 ◽  
pp. 923-927
Author(s):  
Xiao Zhan Yang ◽  
Bing Wang ◽  
Zhen Sheng Li ◽  
Wen Lin Feng
Keyword(s):  
Tissue Engineering ◽  
Composite Nanofibers ◽  
Soft Segment ◽  
Cartilage Tissue Engineering ◽  
Dynamic Contact Angle ◽  
Angle Measurement ◽  
Tissue Engineering Scaffold ◽  
Cartilage Tissue ◽  
Polybutylene Terephthalate ◽  
Scanning Calorimetry

In this work, the composite nanofibers of polybutylene terephthalate/polyethylene glycol (PEG/PBT) with difference intrinsic viscosity and different ratio of the hard-segment to the soft-segment were obtained by gas-electrospun. The PEG/PBT-HA composite nanofibers were also obtained by gas-electrospun. PEG/PBT and PEG/PBT-HA composite nanofibers were characterized using scanning electron microscopy (SEM), horizontal attenuated total reflectance for Fourier transformation infra-red spectrometer (HATR-FTIR), dynamic contact angle measurement and differential scanning calorimetry (DSC). The results strongly suggest that this synthetic matrix combines with the advantages of synthetic biodegradable polymers, nanometer-scale dimension mimicking the natural ECM, may represent an ideal tissue engineering scaffold, especially for soft tissue, such as skin and cartilage tissue engineering scaffold.

scholarly journals Recent Advancements in 3D Printing of Polysaccharide Hydrogels in Cartilage Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 3977
Author(s):  
Jakob Naranda ◽  
Matej Bračič ◽  
Matjaž Vogrin ◽  
Uroš Maver
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Modern Concept ◽  
3 Dimensional ◽  
Scaffold Materials ◽  
Low Cytotoxicity

The application of hydrogels coupled with 3-dimensional (3D) printing technologies represents a modern concept in scaffold development in cartilage tissue engineering (CTE). Hydrogels based on natural biomaterials are extensively used for this purpose. This is mainly due to their excellent biocompatibility, inherent bioactivity, and special microstructure that supports tissue regeneration. The use of natural biomaterials, especially polysaccharides and proteins, represents an attractive strategy towards scaffold formation as they mimic the structure of extracellular matrix (ECM) and guide cell growth, proliferation, and phenotype preservation. Polysaccharide-based hydrogels, such as alginate, agarose, chitosan, cellulose, hyaluronan, and dextran, are distinctive scaffold materials with advantageous properties, low cytotoxicity, and tunable functionality. These superior properties can be further complemented with various proteins (e.g., collagen, gelatin, fibroin), forming novel base formulations termed “proteo-saccharides” to improve the scaffold’s physiological signaling and mechanical strength. This review highlights the significance of 3D bioprinted scaffolds of natural-based hydrogels used in CTE. Further, the printability and bioink formation of the proteo-saccharides-based hydrogels have also been discussed, including the possible clinical translation of such materials.

Research Progress of Scaffold Materials in Cartilage Tissue Engineering

2015 ◽  
Vol 5 (9) ◽  
pp. 673-679 ◽  
Author(s):  
Weimin Zhu ◽  
Jiaming Cui ◽  
Li Duan ◽  
Jielin Chen ◽  
Yanjun Zeng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Research Progress ◽  
Cartilage Tissue ◽  
Scaffold Materials
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