scholarly journals Characterization of local structure and heat dissipation of iron oxide nanoparticles for magnetic hyperthermia treatment

2016 ◽  
Vol 41 (1) ◽  
pp. 25-28 ◽  
Author(s):  
K. Mori ◽  
M. Hachisu ◽  
K. Hyodo ◽  
S. Morimoto ◽  
T. Yamazaki ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Local Structure ◽  
Heat Dissipation ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Hyperthermia Treatment

scholarly journals Treatment of Breast Cancer-Bearing BALB/c Mice with Magnetic Hyperthermia using Dendrimer Functionalized Iron-Oxide Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2310 ◽  
Author(s):  
Marzieh Salimi ◽  
Saeed Sarkar ◽  
Mansoureh Hashemi ◽  
Reza Saber
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
B Cell Lymphoma ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Hyperthermia Treatment

The development of novel nanoparticles for diagnostic and therapeutic applications has been one of the most crucial challenges in cancer theranostics for the last decades. Herein, we functionalized iron oxide nanoparticles (IONPs) with the fourth generation (G4) of poly amidoamine (PAMAM) dendrimers (G4@IONPs) for magnetic hyperthermia treatment of breast cancer in Bagg albino strain C (BALB/c)mice. The survival of breast cancer cells significantly decreased after incubation with G4@IONPs and exposure to an alternating magnetic field (AMF) due to apoptosis and elevation of Bax (Bcl-2 associated X)/Bcl-2(B-cell lymphoma 2) ratio. After intratumoral injection of G4@IONPs, tumor-bearing BALB/c mice were exposed to AMF for 20 min; this procedure was repeated three times every other day. After the last treatment, tumor size was measured every three days. Histopathological and Immunohistochemical studies were performed on the liver, lung, and tumor tissues in treated and control mice. The results did not show any metastatic cells in the liver and lung tissues in the treatment group, while the control mice tissues contained metastatic breast cancer cells. Furthermore, the findings of the present study showed that magnetic hyperthermia treatment inhibited tumor growth by increasing cancer cell apoptosis, as well as reducing the tumor angiogenesis.

Thermal, Mechanical and Magneto-Mechanical Characterization of Liquid Crystalline Elastomers Loaded with Iron Oxide Nanoparticles

2015 ◽  
Vol 1718 ◽  
pp. 3-7
Author(s):  
Stephany Herrera-Posada ◽  
Barbara O. Calcagno ◽  
Aldo Acevedo
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Liquid Crystalline ◽  
Molar Mass ◽  
Oxide Nanoparticles ◽  
Magnetic Actuation ◽  
Scanning Calorimetry ◽  
Elastomeric Matrix ◽  
Alternating Magnetic Fields

ABSTRACTLiquid crystalline elastomers (LCEs) are materials that reveal unusual mechanical, optical and thermal properties due to their molecular orientability characteristic of low molar mass liquid crystals while maintaining the mechanical elasticity distinctive of rubbers. As such, they are considered smart shape-changing responsive systems. In this work, we report on the preparation of magnetic sensitized nematic LCEs using iron oxide nanoparticles with loadings of up to 0.7 wt%. The resultant thermal and mechanical properties were characterized by differential scanning calorimetry, expansion/contraction experiments and extensional tests. The magnetic actuation ability was also evaluated for the neat elastomer and the composite with 0.5 wt% magnetic content, finding reversible contractions of up to 23% with the application of alternating magnetic fields (AMFs) of up to 48 kA/m at 300 kHz. Thus, we were able to demonstrate that the inclusion of magnetic nanoparticles yields LCEs with adjustable properties that can be tailored by changing the amount of particles embedded in the elastomeric matrix, which can be suitable for applications in actuation, sensing, or as smart substrates.

Size-Dependent Mechanisms in AC Magnetic Hyperthermia Response of Iron-Oxide Nanoparticles

2012 ◽  
Vol 48 (4) ◽  
pp. 1320-1323 ◽  
Author(s):  
K. D. Bakoglidis ◽  
K. Simeonidis ◽  
D. Sakellari ◽  
G. Stefanou ◽  
M. Angelakeris
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Size Dependent
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