The functional roles of cyclin-dependent kinase 5 (Cdk5) activators in neuronal and muscle cell differentiation

1999 ◽  
Author(s):  
Kun Lam
Keyword(s):  
Cell Differentiation ◽  
Muscle Cell ◽  
Cyclin Dependent Kinase ◽  
Functional Roles ◽  
Muscle Cell Differentiation ◽  
Cyclin Dependent Kinase 5

scholarly journals C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia

2007 ◽  
Vol 301 (1) ◽  
pp. 70-81 ◽  
Author(s):  
Soonsang Yoon ◽  
Michael J. Molloy ◽  
Melissa P. Wu ◽  
Douglas B. Cowan ◽  
Emanuela Gussoni
Keyword(s):  
Cell Differentiation ◽  
Muscle Cell ◽  
Muscle Cell Differentiation

Increased Mitochondrial Biogenesis and Function Is Necessary for Muscle Cell Differentiation

2015 ◽  
Vol 87 ◽  
pp. S131
Author(s):  
Neelu E Varghese ◽  
Gobinath Shanmugam ◽  
Daniel J Bolus ◽  
Balu K Chacko ◽  
Victor M Darley-Usmar ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Muscle Cell ◽  
Mitochondrial Biogenesis ◽  
Muscle Cell Differentiation ◽  
And Function

scholarly journals Posttranscriptional control of embryonic rat skeletal muscle protein synthesis. Control at the level of translation by endogenous RNA.

1988 ◽  
Vol 107 (3) ◽  
pp. 1085-1098 ◽  
Author(s):  
C R Vanderburg ◽  
M A Nathanson
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Muscle Cell ◽  
Translational Control ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Skeletal Muscle Protein ◽  
Rat Skeletal Muscle ◽  
Total Rna ◽  
Muscle Cell Differentiation

The onset of muscle cell differentiation is associated with increased transcription of muscle-specific mRNA. Studies from this laboratory using 19-d embryonic rat skeletal muscle, suggest that additional, posttranscriptional controls regulate maturation of muscle tissue via a quantitative effect upon translation, and that the regulatory component may reside within the poly A- RNA pool (Nathanson, M.A., E.W. Bush, and C. Vanderburg. 1986. J. Biol. Chem. 261:1477-1486). To further characterize muscle cell translational control, embryonic and adult total RNA were separated into oligo(dT)cellulose-bound (poly A+) and -unbound (poly A-) pools. Unbound material was subjected to agarose gel electrophoresis to resolve constituents of varying molecular size and mechanically cut into five fractions. Material of each fraction was electroeluted and recovered by precipitation. Equivalent loads of total RNA from 19-20-d embryonic rat skeletal muscle exhibited a 40% translational inhibition in comparison to its adult counterpart. Inhibition was not due to decreased message abundance because embryonic, as well as adult muscle, contained equivalent proportions of poly A+ mRNA. An inhibition assay, based upon the translatability of adult RNA and its inhibition by embryonic poly A- RNA, confirmed that inhibition was associated with a 160-2,000-nt poly A- fraction. Studies on the chemical composition of this fraction confirmed its RNA composition, the absence of ribonucleoprotein, and that its activity was absent from similarly fractionated adult RNA. Rescue of inhibition could be accomplished by addition of extra lysate or mRNA; however, smaller proportions of lysate were required, suggesting a strong interaction of inhibitor and components of the translational apparatus. Additional studies demonstrated that the inhibitor acted at the level of initiation, in a dose-dependent fashion. The present studies confirm the existence of translational control in skeletal muscle and suggest that it operates at the embryonic to adult transition. A model of muscle cell differentiation, based upon transcriptional control at the myoblast level, followed by translational regulation at the level of the postmitotic myoblast and/or myotube, is proposed.

Set7 regulates smooth muscle cell differentiation

2017 ◽  
Vol 263 ◽  
pp. e20
Author(s):  
Natasha Kelly Tuano ◽  
Jun Okabe ◽  
Mark Ziemann ◽  
Mark E. Cooper ◽  
Assam El-Osta
Keyword(s):  
Smooth Muscle ◽  
Cell Differentiation ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Muscle Cell Differentiation ◽  
Smooth Muscle Cell Differentiation

scholarly journals Genome-Wide Exploration of miRNA Function in Mammalian Muscle Cell Differentiation

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71927 ◽  
Author(s):  
Anna Polesskaya ◽  
Cindy Degerny ◽  
Guillaume Pinna ◽  
Yves Maury ◽  
Gueorgui Kratassiouk ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Muscle Cell ◽  
Muscle Cell Differentiation ◽  
Mammalian Muscle ◽  
Genome Wide
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