scholarly journals Impact of anatomical liver resection for hepatocellular carcinoma: A systematic review and meta-analysis

2021 ◽  
Vol 25 (1) ◽  
pp. S238-S238
Author(s):  
SeongWook SHIN ◽  
Tae-Seok KIM
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Liver Resection ◽  
Meta Analysis ◽  
Anatomical Liver Resection

Sa1510 - Pure Laparoscopic Versus Open Liver Resection for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-1138
Author(s):  
Jan S. Witowski ◽  
Michal Wysocki ◽  
Mateusz Sitkowski ◽  
Magdalena Mizera ◽  
Zuzanna Malina ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Liver Resection ◽  
Meta Analysis ◽  
Open Liver Resection

scholarly journals Shorter survival after liver pedicle clamping in patients undergoing liver resection for hepatocellular carcinoma revealed by a systematic review and meta-analysis

2021 ◽  
Vol 108 (Supplement_4) ◽  
Author(s):  
C -H Wassmer ◽  
B Moeckli ◽  
T Berney ◽  
C Toso ◽  
L Orci
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Liver Resection ◽  
Tumor Recurrence ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Remnant Liver ◽  
Long Term Outcomes ◽  
The Impact

Abstract Objective Liver pedicle clamping minimizes surgical bleeding during hepatectomy. However, by inducing ischemia-reperfusion injury to the remnant liver, pedicle clamping may be associated with tumor recurrence in the regenerating liver. Hepatocellular carcinoma (HCC) having a high rate of recurrence, evidences demonstrating an eventual association with pedicle clamping is strongly needed. Methods We did a systematic review of the literature until April 2020, looking at studies reporting the impact of liver pedicle clamping on long-term outcomes in patients undergoing liver resection for HCC. Primary and secondary outcomes were overall survival (OS) and disease-free survival, respectively. Results Results were obtained by random-effect meta-analysis and expressed as standardized mean difference (SMD). Eleven studies were included, accounting for 8087 patients. Results of seven studies were pooled in a meta-analysis. Findings indicated that, as compared to control patients who did not receive liver pedicle clamping, those who did had a significantly shorter OS (SMD = -0.172, 95%CI: -0.298 to -0.047, p = 0.007, I2=76.8%) and higher tumor recurrence rates (odds ratio 1.36 1.01 to 1.83. p = 0.044, I2=50.7%). Conclusion This meta-analysis suggests that liver pedicle clamping may have a deleterious impact on long-term outcomes. An individual patient-data meta-analysis of randomized trials evaluating liver pedicle clamping is urgently needed.

scholarly journals Shorter Survival after Liver Pedicle Clamping in Patients Undergoing Liver Resection for Hepatocellular Carcinoma Revealed by a Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 637
Author(s):  
Charles-Henri Wassmer ◽  
Beat Moeckli ◽  
Thierry Berney ◽  
Christian Toso ◽  
Lorenzo A. Orci
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Liver Resection ◽  
Tumor Recurrence ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Remnant Liver ◽  
Long Term Outcomes ◽  
The Impact

Liver pedicle clamping minimizes surgical bleeding during hepatectomy. However, by inducing ischemia-reperfusion injury to the remnant liver, pedicle clamping may be associated with tumor recurrence in the regenerating liver. Hepatocellular carcinoma (HCC) having a high rate of recurrence, evidences demonstrating an eventual association with pedicle clamping is strongly needed. We did a systematic review of the literature until April 2020, looking at studies reporting the impact of liver pedicle clamping on long-term outcomes in patients undergoing liver resection for HCC. Primary and secondary outcomes were overall survival (OS) and disease-free survival, respectively. Results were obtained by random-effect meta-analysis and expressed as standardized mean difference (SMD). Eleven studies were included, accounting for 8087 patients. Results of seven studies were pooled in a meta-analysis. Findings indicated that, as compared to control patients who did not receive liver pedicle clamping, those who did had a significantly shorter OS (SMD = −0.172, 95%CI: −0.298 to −0.047, p = 0.007, I2 = 76.8%) and higher tumor recurrence rates (odds ratio 1.36 1.01 to 1.83. p = 0.044, I2 = 50.7%). This meta-analysis suggests that liver pedicle clamping may have a deleterious impact on long-term outcomes. An individual patient-data meta-analysis of randomized trials evaluating liver pedicle clamping is urgently needed.

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