scholarly journals Predictive Value of Electroencephalography for Seizure Outcome Following Corpus Callosotomy in Children

2011 ◽  
Vol 1 (2) ◽  
pp. 65-70 ◽  
Author(s):  
Go-Un Jeong ◽  
Hunmin Kim ◽  
Byung Chan Lim ◽  
Jong-Hee Chae ◽  
Ki Joong Kim ◽  
...  
Keyword(s):  
Predictive Value ◽  
Seizure Outcome ◽  
Corpus Callosotomy

scholarly journals Seizure outcome after corpus callosotomy in a large paediatric series

2017 ◽  
Vol 60 (2) ◽  
pp. 199-206 ◽  
Author(s):  
David Graham ◽  
Deepak Gill ◽  
Russell C Dale ◽  
Martin M Tisdall ◽  
Keyword(s):  
Seizure Outcome ◽  
Corpus Callosotomy

Predictive value of electrically induced seizures for postsurgical seizure outcome

2020 ◽  
Vol 131 (9) ◽  
pp. 2289-2297 ◽  
Author(s):  
Christopher Kämpfer ◽  
Attila Racz ◽  
Carlos M. Quesada ◽  
Christian E. Elger ◽  
Rainer Surges
Keyword(s):  
Predictive Value ◽  
Seizure Outcome

scholarly journals Epilepsy surgery in tuberous sclerosis complex: the BC Children’s Hospital experience

2015 ◽  
Vol 42 (S1) ◽  
pp. S14-S14
Author(s):  
C Wilbur ◽  
C Sanguansermsri ◽  
H Chable ◽  
A Mihaela ◽  
P Steinbok ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Epilepsy Surgery ◽  
Tuberous Sclerosis Complex ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Seizure Outcome ◽  
Corpus Callosotomy ◽  
Age At Surgery ◽  
Second Resection

Background: Epilepsy occurs in up to 90% of patients with Tuberous Sclerosis Complex (TSC) and is often refractory to medications. Our objective was to assess the safety and outcome of epilepsy surgery in children with TSC at our institution. Methods: We performed a systematic, retrospective chart review of children with TSC who underwent epilepsy surgery at our institution. Patients were identified through epilepsy and clinical neurophysiology databases. Results: 19 patients (out of 81 with TSC) underwent surgery between 1995-2014. Median age at surgery was 4.2 (Range 1.1-15.6) years, with patients having failed a median 4 (Range 0-10) anti-seizure medications. Surgery comprised corpus callosotomy in 2 and resection of one or more tubers in 17. 2 patients had a subsequent second resection. Minor neurologic deficits occurred after 14% of surgeries. Median follow-up was 2.4 years (Range 0.3 -13.8 years) following surgery . At last follow-up, 47% were seizure free, including 2 patients off anti-seizure medication. Conclusions: Epilepsy surgery is safe and effective in carefully selected TSC patients, with the majority having a good seizure outcome. Children with epilepsy secondary to TSC should be referred for epilepsy surgery assessment.

scholarly journals Seizure Outcome after Anterior versus Complete Corpus Callosotomy in Children: A Systematic Review with Meta-Analysis

2015 ◽  
Vol 34 (04) ◽  
pp. 304-308
Author(s):  
Rodrigo Adry ◽  
Sebastião Silva Júnior ◽  
Carlos Pereira ◽  
Jean Oliveira ◽  
Dionei Morais ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Seizure Outcome ◽  
Corpus Callosotomy

Seizure Outcomes After Corpus Callosotomy for Drop Attacks

Neurosurgery ◽  
2013 ◽  
Vol 73 (6) ◽  
pp. 993-1000 ◽  
Author(s):  
Regina S. Bower ◽  
Elaine Wirrell ◽  
Macaulay Nwojo ◽  
Nicholas M. Wetjen ◽  
W. Richard Marsh ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Intractable Epilepsy ◽  
Seizure Outcome ◽  
Seizure Onset ◽  
Corpus Callosotomy ◽  
Drop Attacks ◽  
Younger Age ◽  
Age At Surgery ◽  
Adults And Children

Abstract BACKGROUND: Medically intractable epilepsy involving drop attacks can be difficult to manage and negatively affect quality of life. Most studies investigating the effect of corpus callosotomy (CC) on seizures have been limited, focusing on the pediatric population or drop seizures alone, with little attention to other factors influencing seizure outcome. OBJECTIVE: To assess seizure outcomes after CC in adults and children. METHODS: Retrospective analysis was performed on all patients who underwent CC (anterior two thirds, 1- or 2-stage complete) at our institution between 1990 and 2011. Change in frequency after CC was assessed for drop seizures and other seizure types. Multiple factors were evaluated for impact on seizure outcome. RESULTS: Fifty patients met inclusion criteria. The median age was 1.5 years at seizure onset and 17 years at time of surgery. Anterior two-thirds CC was performed in 28 patients, 1-stage complete in 17, and 2-stage complete in 5. All 3 groups experienced a significant decrease in drop seizures (P < .001, P < .001, and P = .020, respectively), with 40% experiencing complete resolution, and 64% dropping at least 1 frequency category. Other seizure types significantly decreased in anterior two-thirds CC and 1-stage complete (P = .0035, P = .001, respectively). Younger age at surgery correlated with better seizure outcomes (P = .043). CONCLUSION: CC for medically refractory generalizing epilepsy is effective for both drop seizures and other seizure types. CC should be considered soon after a patient has been deemed medically refractory because earlier age at surgery results in lower risk and better outcome.

scholarly journals Corpus Callosotomy for Intractable Epilepsy Revisited: The Children’s Hospital of Michigan Series

2017 ◽  
Vol 32 (7) ◽  
pp. 624-629 ◽  
Author(s):  
Aimee F. Luat ◽  
Eishi Asano ◽  
Ajay Kumar ◽  
Harry T. Chugani ◽  
Sandeep Sood
Keyword(s):  
Vagus Nerve ◽  
Intractable Epilepsy ◽  
Endoscopic Approach ◽  
Seizure Outcome ◽  
Nerve Stimulator ◽  
Corpus Callosotomy ◽  
Seizure Reduction ◽  
Palliative Procedure ◽  
Vagus Nerve Stimulator ◽  
Drug Resistant Epilepsy

Corpus callosotomy is a palliative procedure performed to reduce the severity of drug-resistant epilepsy. The authors assessed its efficacy on different seizure types in 20 subjects (age range 5-19 years); 8 with active vagus nerve stimulator. Fifteen had complete callosotomy, 3 had anterior 2/3, and 2 had anterior 2/3 followed later by complete callosotomy. Ten had endoscopic approach. In all, 65% had ≥ 50% reduction of generalized seizures leading to falls (atonic, tonic, myoclonic); 35% became seizure-free (follow-up period: 6 months to 9 years; mean 3 years). Seizure outcome distribution was better for generalized than for partial seizures ( P = .003). Endoscopic approach was as effective as transcranial approach. Seven subjects who failed vagus nerve stimulator therapy responded with ≥50% seizure reduction. Corpus callosotomy is an effective treatment for intractable generalized epilepsy leading to falls with significant seizure reduction or even elimination of seizures, in the majority of children.

scholarly journals Morphometric Analysis Program and Quantitative Positron Emission Tomography in Presurgical Localization in MRI-negative Epilepsies: a Simultaneous PET/MRI Study

2021 ◽  
Author(s):  
Kun Guo ◽  
Jingjuan Wang ◽  
Zhenming Wang ◽  
Yihe Wang ◽  
Bixiao Cui ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Morphometric Analysis ◽  
Predictive Value ◽  
Surgical Outcome ◽  
Emission Tomography ◽  
Seizure Outcome ◽  
Epileptogenic Zone ◽  
Analysis Program ◽  
Positron Emission ◽  
Sensitivity Specificity

Abstract Purpose: To evaluate morphometric analysis program (MAP) and quantitative positron emission tomography (QPET) in epileptogenic zone (EZ) identification using a simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) system in MRI-negative epilepsies.Methods: Seventy-one localization-related MRI-negative epilepsies underwent preoperative simultaneous PET/MRI examination and surgical resection were enrolled retrospectively. MAP was performed on T1-weighted volumetric sequence and QPET was analyzed using statistical parametric mapping (SPM) with comparison to age-, and gender- matched normal controls. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of MAP, QPET, MAP+ QPET and MAP/QPET in EZ localization were assessed. The correlations between surgical outcome and modalities concordant with cortical resection were analyzed.Results: Forty-five (63.4%) patients had Engel I seizure outcome. The sensitivity, specificity, PPV and NPV of MAP was 64.4%, 69.2%, 78.3% and 52.9%, respectively. The sensitivity, specificity, PPV, NPV of QPET was 73.3%, 65.4%, 78.6%, and 58.6%, respectively. MAP+QPET, defined as two tests concordant with cortical resection, had reduced sensitivity (53.3%) but increased specificity (88.5%) relative to individual tests. MAP/QPET, defined as one or both tests concordant with cortical resection, had increased sensitivity (86.7%) but reduced specificity (46.2%) relative to individual tests. The regions determined by MAP, QPET, MAP+QPET or MAP/QPET concordant with cortical resection was significantly associated with seizure-free outcome, MAP+QPET performed best. Conclusion: The combination of MAP and QPET imaging play a complementary role in EZ localization and this approach can be readily improved surgical outcome in MRI-negative epilepsies.

Seizure outcome after corpus callosotomy: the Taiwan experience

2000 ◽  
Vol 16 (2) ◽  
pp. 87-92 ◽  
Author(s):  
S. -Y. Kwan ◽  
T. -T. Wong ◽  
K. -P. Chang ◽  
C. -S. Chi ◽  
T. -F. Yang ◽  
...  
Keyword(s):  
Seizure Outcome ◽  
Corpus Callosotomy

Complete versus anterior two-thirds corpus callosotomy in children: analysis of outcome

2010 ◽  
Vol 6 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Laleh Jalilian ◽  
David D. Limbrick ◽  
Karen Steger-May ◽  
Jim Johnston ◽  
Alex K. Powers ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Class I ◽  
Seizure Outcome ◽  
Corpus Callosotomy ◽  
Female Ratio ◽  
Disconnection Syndrome ◽  
Parental Assessment ◽  
Initial Procedure ◽  
Clinically Significant ◽  
Daily Function

Object The goal of this study was to evaluate the efficacy of anterior versus complete sectioning of the corpus callosum in children suffering from medically refractory epilepsy. The authors report seizure outcome in patients who underwent anterior two-thirds or complete corpus callosotomy (CC) during the period 1995–2008 at St. Louis Children's Hospital. Methods The medical records of 27 children and adolescents with a minimum follow-up of 6 months were retrospectively evaluated with respect to seizure status, anticonvulsant outcomes, and subjective results. Preoperatively, patients suffered from a variety of seizure types that occurred daily, weekly, or episodically. The male/female ratio was 19:8, and patients ranged in age between 3 and 19 years (mean 9.93 years). Seizure outcome, parental assessment of daily function, and changes in the number of prescribed antiepileptic drugs were all assessed. Results Fifteen patients underwent an initial anterior two-thirds CC, and 12 underwent a complete CC. Of the 15 patients who underwent an anterior CC, 7 went on to receive a posterior CC. Seizure control was superior in children undergoing a complete CC (91%, Class I–III) versus an anterior two-thirds CC (75%, Class I–III). Seizure types most affected by CC included atonic, myoclonic, and absence. The number of postoperative antiepileptic drugs did not significantly change following CC in either the anterior only or complete groups. One patient experienced a transient disconnection syndrome that resolved within 4 weeks, and 4 patients experienced mild hemiparesis and speech delays that resolved with therapy. Three patients experienced surgical complications requiring a second operation. The overall daily function and attentiveness of the patients improved. Conclusions A complete CC should be considered as the initial procedure in lower-functioning children afflicted by absence, atonic, or myoclonic seizures. Severely affected higher-functioning children may also benefit from a complete CC, without clinically significant disconnection syndromes. A completion posterior CC may benefit patients in whom a prior anterior CC has failed.

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