scholarly journals Measuring endogenous corticosterone in laboratory mice - a mapping review, meta-analysis, and open source database_suppl2

ALTEX ◽  
2020 ◽  
Author(s):  
Stevie van der Mierden
2021 ◽  
Author(s):  
Ferran Cuenca‐Martínez ◽  
Álvaro Reina‐Varona ◽  
Juan Castillo‐García ◽  
Roy La Touche ◽  
Santiago Angulo‐Díaz‐Parreño ◽  
...  

2020 ◽  
Vol 118 ◽  
pp. 828-845
Author(s):  
Aida Herranz-Gómez ◽  
Cristian Gaudiosi ◽  
Santiago Angulo-Díaz-Parreño ◽  
Luis Suso-Martí ◽  
Roy La Touche ◽  
...  

2017 ◽  
Vol 8 (8) ◽  
pp. 941-947 ◽  
Author(s):  
Byron C. Wallace ◽  
Marc J. Lajeunesse ◽  
George Dietz ◽  
Issa J. Dahabreh ◽  
Thomas A. Trikalinos ◽  
...  

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Prasanth Varma Kakarlapudi ◽  
Qusay H. Mahmoud

Blockchain technology was introduced through Bitcoin in a 2008 whitepaper by the mysterious Satoshi Nakamoto. Since its inception, it has gathered great attention because of its unique properties—immutability and decentralized authority. This technology is now being implemented in various fields such as healthcare, IoT, data management, etc., apart from cryptocurrencies. As it is a newly emerging technology, researchers and organizations face many challenges in integrating this technology into other fields. Consent management is one of the essential processes in an organization because of the ever-evolving privacy laws, which are introduced to provide more control to users over their data. This paper is a systematic review of Blockchain’s application in the field of consent and privacy data management. The review discusses the adaptation of Blockchain in healthcare, IoT, identity management, and data storage. This analysis is formed on the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and a process of systematic mapping review. We provide analysis of the development, challenges, and limitations of blockchain technology for consent management.


2021 ◽  
Author(s):  
Brittany A Mok ◽  
Vibha Viswanathan ◽  
Agudemu Borjigin ◽  
Ravinderjit Singh ◽  
Homeira I Kafi ◽  
...  

Anonymous web-based experiments are increasingly and successfully used in many domains of behavioral research. However, online studies of auditory perception, especially of psychoacoustic phenomena pertaining to low-level sensory processing, are challenging because of limited available control of the acoustics, and the unknown hearing status of participants. Here, we outline our approach to mitigate these challenges and validate our procedures by comparing web-based measurements to lab-based data on a range of classic psychoacoustic tasks. Individual tasks were created using jsPsych, an open-source javascript front-end library. Dynamic sequences of psychoacoustic tasks were implemented using Django, an open-source library for web applications, and combined with consent pages, questionnaires, and debriefing pages. Subjects were recruited via Prolific, a web-based human-subject marketplace. Guided by a meta-analysis of normative data, we developed and validated a screening procedure to select participants for (putative) normal-hearing status; this procedure combined thresholding of scores in a suprathreshold cocktail-party task with filtering based on survey responses. Headphone use was standardized by supplementing procedures from prior literature with a binaural hearing task. Individuals meeting all criteria were re-invited to complete a range of classic psychoacoustic tasks. Performance trends observed in re-invited participants were in excellent agreement with lab-based data for fundamental frequency discrimination, gap detection, sensitivity to interaural time delay and level difference, comodulation masking release, word identification, and consonant confusions. Our results suggest that web-based psychoacoustics is a viable complement to lab-based research. Source code for our infrastructure is also provided.


2021 ◽  
Vol 14 ◽  
Author(s):  
Justin A. Varholick ◽  
Jeremy D. Bailoo ◽  
Ashley Jenkins ◽  
Bernhard Voelkl ◽  
Hanno Würbel

Background: Social dominance status (e.g., dominant or subordinate) is often associated with individual differences in behavior and physiology but is largely neglected in experimental designs and statistical analysis plans in biomedical animal research. In fact, the extent to which social dominance status affects common experimental outcomes is virtually unknown. Given the pervasive use of laboratory mice and culminating evidence of issues with reproducibility, understanding the role of social dominance status on common behavioral measures used in research may be of paramount importance.Methods: To determine whether social dominance status—one facet of the social environment—contributes in a systematic way to standard measures of behavior in biomedical science, we conducted a systematic review of the existing literature searching the databases of PubMed, Embase, and Web of Science. Experiments were divided into several domains of behavior: exploration, anxiety, learned helplessness, cognition, social, and sensory behavior. Meta-analyses between experiments were conducted for the open field, elevated plus-maze, and Porsolt forced swim test.Results: Of the 696 publications identified, a total of 55 experiments from 20 published studies met our pre-specified criteria. Study characteristics and reported results were highly heterogeneous across studies. A systematic review and meta-analyses, where possible, with these studies revealed little evidence for systematic phenotypic differences between dominant and subordinate male mice.Conclusion: This finding contradicts the notion that social dominance status impacts behavior in significant ways, although the lack of an observed relationship may be attributable to study heterogeneity concerning strain, group-size, age, housing and husbandry conditions, and dominance assessment method. Therefore, further research considering these secondary sources of variation may be necessary to determine if social dominance generally impacts treatment effects in substantive ways.


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