scholarly journals An Improved Machine Learning Approach to Enhance the Predictive Accuracy for Screening Potential Active USP1/UAF1 Inhibitors

2017 ◽  
Vol 8 (4) ◽  
Author(s):  
Syed Asif ◽  
Ahmed Hamza
Keyword(s):  
Machine Learning ◽  
Predictive Accuracy ◽  
Learning Approach ◽  
Machine Learning Approach

Comparative analysis of a deep learning approach with various classification techniques for credit score computation

2020 ◽  
Vol 13 ◽  
Author(s):  
Arvind Pandey ◽  
Shipra Shukla ◽  
Krishna Kumar Mohbey
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Comparative Analysis ◽  
Predictive Accuracy ◽  
Credit Scoring ◽  
Gradient Boosting ◽  
Learning Approach ◽  
Probit Regression ◽  
Credit Score ◽  
Machine Learning Approach

Background: Large financial companies are perpetually creating and updating customer scoring techniques. From a risk management view, this research for the predictive accuracy of probability is of vital importance than the traditional binary result of classification, i.e., non-credible and credible customers. The customer's default payment in Taiwan is explored for the case study. Objective: The aim is to audit the comparison between the predictive accuracy of the probability of default with various techniques of statistics and machine learning. Method: In this paper, nine predictive models are compared from which the results of the six models are taken into consideration. Deep learning-based H2O, XGBoost, logistic regression, gradient boosting, naïve Bayes, logit model, and probit regression comparative analysis is performed. The software tools such as R and SAS (university edition) is employed for machine learning and statistical model evaluation. Results: Through the experimental study, we demonstrate that XGBoost performs better than other AI and ML algorithms. Conclusion: Machine learning approach such as XGBoost effectively used for credit scoring, among other data mining and statistical approaches.

scholarly journals Integration of Machine Learning and Computational Fluid Dynamics to Develop Turbulence Models for Improved Turbine Wake Mixing Prediction

2020 ◽  
Author(s):  
Harshal D. Akolekar ◽  
Yaomin Zhao ◽  
Richard D. Sandberg ◽  
Roberto Pacciani
Keyword(s):  
Machine Learning ◽  
Predictive Accuracy ◽  
Model Development ◽  
Learning Approach ◽  
Near Wake ◽  
Machine Learning Approach ◽  
Non Linear ◽  
Turbulence Closures ◽  
Unsteady Rans ◽  
Turbine Wake

Abstract This paper presents development of accurate turbulence closures for wake mixing prediction by integrating a machine-learning approach with Reynolds Averaged Navier-Stokes (RANS)-based computational fluid dynamics (CFD). The data-driven modeling framework is based on the gene expression programming (GEP) approach previously shown to generate non-linear RANS models with good accuracy. To further improve the performance and robustness of the data-driven closures, here we exploit that GEP produces tangible models to integrate RANS in the closure development process. Specifically, rather than using as cost function a comparison of the GEP-based closure terms with a frozen high-fidelity dataset, each GEP model is instead automatically implemented into a RANS solver and the subsequent calculation results compared with reference data. By first using a canonical turbine wake with inlet conditions prescribed based on high-fidelity data, we demonstrate that the CFD-driven machine-learning approach produces non-linear turbulence closures that are physically correct, i.e. predict the right downstream wake development and maintain an accurate peak wake loss throughout the domain. We then extend our analysis to full turbine-blade cases and show that the model development is sensitive to the training region due to the presence of deterministic unsteadiness in the near wake region. Models developed including this region have artificially large diffusion coefficients to over-compensate for the vortex shedding steady RANS cannot capture. In contrast, excluding the near wake region in the model development produces the correct physical model behavior, but predictive accuracy in the near-wake remains unsatisfactory. We show that this can be remedied by using the physically consistent models in unsteady RANS, implying that the non-linear closure producing the best predictive accuracy depends on whether it will be deployed in RANS or unsteady RANS calculations. Overall, the models developed with the CFD-assisted machine learning approach were found to be robust and capture the correct physical behavior across different operating conditions.

scholarly journals A Multimodality Machine Learning Approach to Differentiate Severe and Nonsevere COVID-19: Model Development and Validation

10.2196/23948 ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. e23948
Author(s):  
Yuanfang Chen ◽  
Liu Ouyang ◽  
Forrest S Bao ◽  
Qian Li ◽  
Lei Han ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Laboratory Test ◽  
Predictive Accuracy ◽  
Learning Approach ◽  
Test Results ◽  
Laboratory Test Results ◽  
Machine Learning Approach ◽  
Forest Models ◽  
Random Forest Models

Background Effectively and efficiently diagnosing patients who have COVID-19 with the accurate clinical type of the disease is essential to achieve optimal outcomes for the patients as well as to reduce the risk of overloading the health care system. Currently, severe and nonsevere COVID-19 types are differentiated by only a few features, which do not comprehensively characterize the complicated pathological, physiological, and immunological responses to SARS-CoV-2 infection in the different disease types. In addition, these type-defining features may not be readily testable at the time of diagnosis. Objective In this study, we aimed to use a machine learning approach to understand COVID-19 more comprehensively, accurately differentiate severe and nonsevere COVID-19 clinical types based on multiple medical features, and provide reliable predictions of the clinical type of the disease. Methods For this study, we recruited 214 confirmed patients with nonsevere COVID-19 and 148 patients with severe COVID-19. The clinical characteristics (26 features) and laboratory test results (26 features) upon admission were acquired as two input modalities. Exploratory analyses demonstrated that these features differed substantially between two clinical types. Machine learning random forest models based on all the features in each modality as well as on the top 5 features in each modality combined were developed and validated to differentiate COVID-19 clinical types. Results Using clinical and laboratory results independently as input, the random forest models achieved >90% and >95% predictive accuracy, respectively. The importance scores of the input features were further evaluated, and the top 5 features from each modality were identified (age, hypertension, cardiovascular disease, gender, and diabetes for the clinical features modality, and dimerized plasmin fragment D, high sensitivity troponin I, absolute neutrophil count, interleukin 6, and lactate dehydrogenase for the laboratory testing modality, in descending order). Using these top 10 multimodal features as the only input instead of all 52 features combined, the random forest model was able to achieve 97% predictive accuracy. Conclusions Our findings shed light on how the human body reacts to SARS-CoV-2 infection as a unit and provide insights on effectively evaluating the disease severity of patients with COVID-19 based on more common medical features when gold standard features are not available. We suggest that clinical information can be used as an initial screening tool for self-evaluation and triage, while laboratory test results should be applied when accuracy is the priority.

scholarly journals Utility of Machine Learning Approach with Neuropsychological Tests in Predicting Functional Impairment of Alzheimer’s Disease

2021 ◽  
pp. 1-16
Author(s):  
Seyul Kwak ◽  
Dae Jong Oh ◽  
Yeong-Ju Jeon ◽  
Da Young Oh ◽  
Su Mi Park ◽  
...  
Keyword(s):  
Machine Learning ◽  
Functional Impairment ◽  
Linear Models ◽  
Predictive Accuracy ◽  
Nonlinear Models ◽  
Learning Approach ◽  
High Complexity ◽  
Neuropsychological Battery ◽  
Machine Learning Approach ◽  
Summary Index

Background: In assessing the levels of clinical impairment in dementia, a summary index of neuropsychological batteries has been widely used in describing the overall functional status. Objective: It remains unexamined how complex patterns of the test performances can be utilized to have specific predictive meaning when the machine learning approach is applied. Methods: In this study, the neuropsychological battery (CERAD-K) and assessment of functioning level (Clinical Dementia Rating scale and Instrumental Activities of Daily Living) were administered to 2,642 older adults with no impairment (n = 285), mild cognitive impairment (n = 1,057), and Alzheimer’s disease (n = 1,300). Predictive accuracy on functional impairment level with the linear models of the single total score or multiple subtest scores (Model 1, 2) and support vector regression with low or high complexity (Model 3, 4) were compared across different sample sizes. Results: The linear models (Model 1, 2) showed superior performance with relatively smaller sample size, while nonlinear models with low and high complexity (Model 3, 4) showed an improved accuracy with a larger dataset. Unlike linear models, the nonlinear models showed a gradual increase in the predictive accuracy with a larger sample size (n >  500), especially when the model training is allowed to exploit complex patterns of the dataset. Conclusion: Our finding suggests that nonlinear models can predict levels of functional impairment with a sufficient dataset. The summary index of the neuropsychological battery can be augmented for specific purposes, especially in estimating the functional status of dementia.

1552-P: Machine Learning Approach to Decision-Making for Initial Insulin Use in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1552-P
Author(s):  
KAZUYA FUJIHARA ◽  
MAYUKO H. YAMADA ◽  
YASUHIRO MATSUBAYASHI ◽  
MASAHIKO YAMAMOTO ◽  
TOSHIHIRO IIZUKA ◽  
...  
Keyword(s):  
Machine Learning ◽  
Type 2 Diabetes ◽  
Decision Making ◽  
Japanese Patients ◽  
Learning Approach ◽  
Machine Learning Approach ◽  
Insulin Use

A Machine Learning Approach to Jet-Surface Interaction Noise Modeling

2020 ◽  
Author(s):  
Clifford A. Brown ◽  
Jonny Dowdall ◽  
Brian Whiteaker ◽  
Lauren McIntyre
Keyword(s):  
Machine Learning ◽  
Surface Interaction ◽  
Learning Approach ◽  
Noise Modeling ◽  
Machine Learning Approach
Sign in / Sign up

Export Citation Format

Share Document