scholarly journals Aggression and Hostility in Overian Cancer Patients as the Consequence of Affective and Cognitive Disorders (Part 1)

2019 ◽  
Vol 12 (1) ◽  
pp. 71-82
Author(s):  
A.S. Belozer ◽  
Author(s):  
Marvin Omar Delgado Guay

Most advanced cancer patients develop psychological symptoms, either alone or in combination with physical symptoms. Frequently psychological symptoms complicate management of physical symptoms such as pain. Routine screening is essential for diagnosis. Among the many possible psychological symptoms, the most common are adjustment disorders, anxiety disorders, depressive disorders, and cognitive disorders, which can be major sources of distress for patients and can pose significant management problems. Treatment may include combination of psychotherapy as well as pharmacotherapy. In this chapter we will review the diagnosis, and management of the most common psychological symptoms such as anxiety and depression experienced by the patients receiving palliative care.


2021 ◽  
pp. 137-145
Author(s):  
Christian Bjerre-Real ◽  
James C. Root ◽  
Yesne Alici ◽  
Julia A. Kearney ◽  
William S. Breitbart

Cognitive syndromes are commonly encountered among cancer patients. Although aging is an important risk factor for cognitive disorders, in oncology settings there are additional risk factors, including primary or metastatic brain tumors, medical comorbidities, cancer treatments, and depression, that place all age groups at risk for cognitive syndromes. Delirium, a common cognitive syndrome among hospitalized cancer patients, has been shown to increase risk of long-term cognitive impairment. Dementia is a risk factor for delirium development as well. Patients with cognitive deficits may not be able to carry out activities of daily living, such as medication maintenance, food preparation, and transportation. Treatment adherence, vigilance in monitoring and reporting of cancer and cancer treatment–related symptoms, and the ability to make informed decisions on cancer treatment options necessitate intact cognitive functioning. Therefore, screening for cognitive syndromes among cancer patients is an important part of initial assessment, particularly in high-risk populations. This chapter will provide a comprehensive review of the screening and assessment measures used to identify and assess patients with delirium and dementia. A brief overview of common dementia syndromes is also included as relevant to psycho-oncologists caring for older adults with cancer.


2012 ◽  
Vol 27 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Dyah A. Perwitasari ◽  
Robert J.H.M. Van Der Straaten ◽  
Mustofa Mustofa ◽  
Judith A.M. Wessels ◽  
Hans Gelderblom ◽  
...  

Background The 5-hydroxytryptamine (5-HT3) receptor is a ligand-operated ion channel with five different receptor subunits (5-HT3A, B, C, D, and E) found in humans. Activation of 5-HT3 receptors influences various effects such as drug-induced emesis and causes behavioral problems such as anxiety, depression and cognitive disorders. To explore interethnic differences in the response to 5-HT3 antagonists, we studied haplotype frequencies in the gene encoding the 5-HT3B receptor in Asians and Caucasians. Methods Three single nucleotide polymorphisms (SNPs) of the 5-HT3B receptor gene, i.e., deletion AAG at the 5′-UTR position, 18792A>G at the intron position, and 46698G>A at the 3′ near gene position, were selected and genotyped in 165 Indonesian cancer patients and 188 Caucasian healthy volunteers. Haplotypes were set with gPlink, whereas the differences in haplotype frequencies between Indonesians and Caucasians were compared using multivariate analysis. Results The haplotype profiles based on the deletion AAG, 18792A>G and 46698G>A were AAGAA, AAGAG, AAGGG, and deletion AG in both Indonesians and Caucasians. The frequency of the AAGAG haplotype was 54.8% in Indonesians and 39.9% in Caucasians (p<0.05). The frequency of the AAGGG haplotype was 14.3% in Indonesians and 29.3% in Caucasians. Moreover, there were significant differences in the frequencies of haplotype pairs between Indonesians and Caucasians (p<0.001). Conclusion Indonesian cancer patients had significantly different AAGAG and AAGGG haplotype frequencies of the gene encoding the 5-HT3B receptor compared to healthy Caucasians. This finding could be useful for understanding interethnic differences in the response to drugs targeting the 5-HT3B receptor in cancer-treatment-related emesis.


2021 ◽  
Vol 160 (1) ◽  
pp. 234-243
Author(s):  
Diana Samoil ◽  
Nazek Abdelmutti ◽  
Lisa Ould Gallagher ◽  
Nazlin Jivraj ◽  
Naa Kwarley Quartey ◽  
...  

2007 ◽  
Vol 177 (4S) ◽  
pp. 297-297
Author(s):  
Kristina Schwamborn ◽  
Rene Krieg ◽  
Ruth Knüchel-Clarke ◽  
Joachim Grosse ◽  
Gerhard Jakse

2007 ◽  
Vol 177 (4S) ◽  
pp. 130-130
Author(s):  
Markus Graefen ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Felix K.-H. Chun ◽  
Alwyn M. Reuther ◽  
...  

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