scholarly journals Morphometric Analysis of Subaxial Cervical Spine Pedicles in a Middle Eastern Population

10.14444/8061 ◽  
2021 ◽  
pp. 8061
Author(s):  
Khalid Alsaleh ◽  
Fahad Essbaiheen ◽  
Khalifah Aldosari ◽  
Bandar Alsubei ◽  
Mahammad Alabdulkareeem
Keyword(s):  
Cervical Spine ◽  
Morphometric Analysis ◽  
Middle Eastern ◽  
Eastern Population ◽  
Subaxial Cervical Spine ◽  
Middle Eastern Population

scholarly journals REPRODUCTIBILITY OF A METABOLITE RISK SCORE TO PREDICT CORONARY HEART DISEASE IN A MIDDLE EASTERN POPULATION

2021 ◽  
Vol 77 (18) ◽  
pp. 107
Author(s):  
Ayman El-Menyar ◽  
Ehsan Ullah ◽  
Khalid Kunji ◽  
Reem Elsousy ◽  
Amna Al-Nesf ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Risk Score ◽  
Middle Eastern ◽  
Eastern Population ◽  
Middle Eastern Population

scholarly journals Validation of the Framingham hypertension risk score in a middle eastern population: Tehran lipid and glucose study (TLGS)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fatemeh Koohi ◽  
Ewout W. Steyerberg ◽  
Leila Cheraghi ◽  
Alireza Abdshah ◽  
Fereidoun Azizi ◽  
...  
Keyword(s):  
Simple Model ◽  
Risk Score ◽  
Screening Tool ◽  
Middle Eastern ◽  
Predictive Ability ◽  
Eastern Population ◽  
Hypertension Risk ◽  
Graphical Comparison ◽  
Middle Eastern Population

Abstract Background The Framingham hypertension risk score is a well-known and simple model for predicting hypertension in adults. In the current study, we aimed to assess the predictive ability of this model in a Middle Eastern population. Methods We studied 5423 participants, aged 20–69 years, without hypertension, who participated in two consecutive examination cycles of the Tehran Lipid and Glucose Study (TLGS). We assessed discrimination based on Harrell’s concordance statistic (c-index) and calibration (graphical comparison of predicted vs. observed). We evaluated the original, recalibrated (for intercept and slope), and revised (for beta coefficients) models. Results Over the 3-year follow-up period, 319 participants developed hypertension. The Framingham hypertension risk score performed well in discriminating between individuals who developed hypertension and those who did not (c-index = 0.81, 95% CI: 0.79–0.83). Initially, there was a systematic underestimation of the original risk score (events predicted), which was readily corrected by a simple model revision. Conclusions The revised Framingham hypertension risk score can be used as a screening tool in public health and clinical practice to facilitate the targeting of preventive interventions in high-risk Middle Eastern people.

scholarly journals Molecular Characterization of Prostate Cancer in Middle Eastern Population Highlights Differences with Western Populations with Prognostic Implication

2019 ◽  
Author(s):  
Ramy A. Abdelsalam ◽  
Ibrahim Khalifeh ◽  
Alan Box ◽  
Maria Kalantarian ◽  
Sunita Ghosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Middle Eastern ◽  
Genomic Alteration ◽  
Published Data ◽  
Lower Grade ◽  
Eastern Population ◽  
Western Population ◽  
Pten Loss ◽  
Middle Eastern Population ◽  
Grade Groups

Abstract Background To investigate the incidence and prognostication of ERG, PTEN and SPINK1 protein expressions in prostate cancer cohort of Middle Eastern descent in comparison to published data from Western populationMethods Immunohistochemistry for ERG, PTEN and SPINK1 was performed in cohort of localized PCa (n=340). Data correlated to pathological and clinical outcomes and compared to Western populations.Results ERG expression and PTEN loss noted in 123/288 (42.7%) and 91/297 (30.6%) of patients, respectively. SPINK1 expression assessed in subset of cases, noted in 6/150 (4%) of patients. Only ERG expression was associated with grade groups, being more common in lower grade groups (1-3 vs 4-5; p=0.04). In contrast to Western population, PTEN loss foci were more likely to be ERG negative, observed in 81% of tumor foci and patients with PTEN neg/ERG pos were more likely to exhibit biochemical recurrence (OR 2.831; 95% CI: 1.10-726, p=0.03). This association remained significant in multivariate analysis (OR 2.68; 95% CI: 0.98-7.33, p=0.05), after adjusting for GG, path stage and surgical margin.Conclusion This study documents significant differences in key molecular events in PCa in Middle Eastern population compared to Western populations that could explain differences in PCa incidence, progression and prognostication. ERG, PTEN and SPINK1 genomic alteration occur less frequently and the enrichment of ERG for PTEN loss is not observed. Additionally, patients with combined PTEN loss/ERG positive are at highest rate for BCR vs North American Caucasian population where PTEN loss alone seems to be associated with the worst clinical outcome. The data presented here further support differences in clonal evolution between Middle Eastern and Western population in relation to PCa and add further insight to understanding PCa molecular pathways.

Clinical presentation and outcomes of acute diverticulitis in a Middle Eastern population

2019 ◽  
Vol 20 (2) ◽  
pp. 99-102
Author(s):  
Jasim Alabbad ◽  
Fawaz Abdul Raheem ◽  
Saba Al-Saddah ◽  
Abdulaziz Al-Mubarak
Keyword(s):  
Clinical Presentation ◽  
Acute Diverticulitis ◽  
Middle Eastern ◽  
Eastern Population ◽  
Middle Eastern Population

THE APPLICALITY OF GLOBAL LUNG INITIVE 2012 ON A MIDDLE EASTERN POPULATION

CHEST Journal ◽  
2019 ◽  
Vol 155 (6) ◽  
pp. A382
Author(s):  
W. Alqerem ◽  
A. Hammad ◽  
R. AlQirem ◽  
J. Ling
Keyword(s):  
Middle Eastern ◽  
Eastern Population ◽  
Middle Eastern Population

Outcomes of dual mobility cups in a young Middle Eastern population and its influence on life style

2017 ◽  
Vol 41 (3) ◽  
pp. 619-624 ◽  
Author(s):  
Chahine Assi ◽  
Elie El-Najjar ◽  
Camille Samaha ◽  
Kaissar Yammine
Keyword(s):  
Life Style ◽  
Middle Eastern ◽  
Dual Mobility ◽  
Eastern Population ◽  
Middle Eastern Population ◽  
Dual Mobility Cups

scholarly journals Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population

Genomics ◽  
2020 ◽  
Vol 112 (2) ◽  
pp. 1746-1753
Author(s):  
Abdul K. Siraj ◽  
Rong Bu ◽  
Kaleem Iqbal ◽  
Sandeep Kumar Parvathareddy ◽  
Nabil Siraj ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Middle Eastern ◽  
Multiple Organ ◽  
Telomerase Reverse Transcriptase ◽  
Eastern Population ◽  
Middle Eastern Population ◽  
Promoter Mutations
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