scholarly journals Stem Cells and Intervertebral Disc Regeneration Overview—What They Can and Can't Do

10.14444/8054 ◽  
2021 ◽  
pp. 8054
Author(s):  
Gianluca Vadalà ◽  
Luca Ambrosio ◽  
Fabrizio Russo ◽  
Rocco Papalia ◽  
Vincenzo Denaro
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

scholarly journals Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Wen-Ching Tzaan ◽  
Hsien-Chih Chen
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Intervertebral Disc ◽  
Bone Marrow Stem Cells ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Hematopoietic Stem ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
Stimulating Factor

Intervertebral disc (IVD) degeneration is a multifactorial process that is influenced by contributions from genetic predisposition, the aging phenomenon, lifestyle conditions, biomechanical loading and activities, and other health factors (such as diabetes). Attempts to decelerate disc degeneration using various techniques have been reported. However, to date, there has been no proven technique effective for broad clinical application. Granulocyte colony-stimulating factor (GCSF) is a growth factor cytokine that has been shown to enhance the availability of circulating hematopoietic stem cells to the brain and heart as well as their capacity for mobilization of mesenchymal bone marrow stem cells. GCSF also exerts significant increases in circulating neutrophils as well as potent anti-inflammatory effects. In our study, we hypothesize that GCSF can induce bone marrow stem cells differentiation and mobilization to regenerate the degenerated IVD. We found that GCSF had no contribution in disc regeneration or maintenance; however, there were cell proliferation within end plates. The effects of GCSF treatment on end plates might deserve further investigation.

scholarly journals Stem cells in intervertebral disc regeneration–more talk than action?

BIOCELL ◽  
2022 ◽  
Vol 46 (4) ◽  
pp. 893-898
Author(s):  
PETRA KRAUS ◽  
ANKITA SAMANTA ◽  
SINA LUFKIN ◽  
THOMAS LUFKIN
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

scholarly journals Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future

2008 ◽  
Vol 12 (6a) ◽  
pp. 2205-2216 ◽  
Author(s):  
R. J. W. Hoogendoorn ◽  
Z. F. Lu ◽  
R. J. Kroeze ◽  
R. A. Bank ◽  
P. I. Wuisman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Adipose Stem Cells ◽  
Current Status ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
The Future

scholarly journals Stem cells sources for intervertebral disc regeneration

2016 ◽  
Vol 8 (5) ◽  
pp. 185 ◽  
Author(s):  
Gianluca Vadalà ◽  
Fabrizio Russo ◽  
Luca Ambrosio ◽  
Mattia Loppini ◽  
Vincenzo Denaro
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

scholarly journals Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

Methods ◽  
2016 ◽  
Vol 99 ◽  
pp. 69-80 ◽  
Author(s):  
Stephen M. Richardson ◽  
Gauthaman Kalamegam ◽  
Peter N. Pushparaj ◽  
Csaba Matta ◽  
Adnan Memic ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration
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