scholarly journals Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting

2020 ◽  
Vol 39 (2) ◽  
pp. 178-189
Author(s):  
Venkatesh A. Murugan ◽  
Bryan O’Sullivan Murphy ◽  
Carolyn Dupuis ◽  
Alan Goldstein ◽  
Young H. Kim
Keyword(s):  
First Trimester ◽  
Acute Setting

Role of Serum β-HCG doubling in Diagnosis of Early Pregnancy and its Management Strategy

2020 ◽  
Vol 16 ◽  
Author(s):  
Divya Mirji ◽  
Shubha Rao ◽  
Akhila Vasudeva ◽  
Roopa P.S
Keyword(s):  
Ectopic Pregnancy ◽  
Early Pregnancy ◽  
Management Strategy ◽  
Transvaginal Ultrasound ◽  
Expectant Management ◽  
First Trimester ◽  
Intrauterine Pregnancy ◽  
Β Hcg ◽  
Pregnancy Of Unknown Location

Background: Pregnancy of unknown location (PUL) is defined as the absence of intrauterine or extrauterine sac and Beta Human Chorionic Gonadotropin levels (β-HCG) above the discriminatory zone of 1500 mIU/ml. It should be noted that PUL is not always an ectopic; however, by measuring the trends of serum β-HCG, we can determine the outcome of a PUL. Objective: This study aims to identify the various trends β-HCG levels in early pregnancy and evaluate the role of β-HCG in the management strategy. Methods: We conducted a prospective observational study of pregnant women suspected with early pregnancy. Cases were classified as having a pregnancy of unknown location (PUL) by transvaginal ultrasound and ß-HCG greater than 1000 mIU/ml. Expectant management was done until there was a definite outcome. All the collected data were analyzed by employing the chi-square test using SPSS version 20. Results: Among 1200 women who had early first trimester scans, 70 women who fulfilled our criteria of PUL and ß-HCG > 1000 mIU/ml were recruited in this study. In our study, the mean age of the participants was 30±5.6yrs, and the overall mean serum ß-HCG was 3030±522 mIU/ml. The most common outcome observed was an ectopic pregnancy, 47% in our study. We also found the rate of failing pregnancy was 27%, and that of intrauterine pregnancy (IUP) was 25%. Overall, in PUL patients diagnosed with ectopic pregnancy, 9% behaved like IUP, and 4% had an atypical trend in their ß-HCG. Those who had an IUP, 11% had a suboptimal increase in ß-HCG. Conclusion: PUL rate in our unit was 6%. Majority of the outcome of PUL was ectopic in our study. Every case of PUL should be managed based on the initial ß-HCG values, clinical assessments and upon the consent of the patient.

scholarly journals Cytomegalovirus Infection during Pregnancy and Its Impact on the Intrauterine Fetal Development – Case Report

2016 ◽  
Vol 4 (3) ◽  
pp. 449-452 ◽  
Author(s):  
Mariya Angelova Angelova ◽  
Emil Kovachev ◽  
Nikolai Todorov
Keyword(s):  
Clinical Manifestations ◽  
First Trimester ◽  
Time Interval ◽  
Good Prediction ◽  
Ultrasound Screening ◽  
Serological Tests ◽  
Ultrasound Findings ◽  
First Trimester Of Pregnancy ◽  
Brain Ventricle

AIM: The aim of this publication is to present a case of CMV infection during pregnancy, with clinical manifestations of the development of microcephaly and simultaneous dilatation of the 3rd and 4th brain ventricle at 23 weeks gestation. This article discusses the role of ultrasound screening in the second trimester of pregnancy.CASE PRESENTATION: We present the case of a 25-year-old woman with the initials S.K. in her second pregnancy that came to our antenatal Consulting Centre. The first screening for blood count, blood group, biochemistry and serology showed results within the reference range. The patient came for a second comprehensive biochemical screening at 17 – 18 weeks gestation. The results showed the low genetic risk of congenital anomalies. Fetal morphology of the fetus was normal. S.K. came again for consultation at 22 weeks gestation in connection with the admittance of her first 3-year-old child to the hospital because of pneumonia. Serological tests of the child had shown elevated CMV titer - specific IgM. Then we made new serological tests of the patient and the results have shown that the patient was most likely infected by CMV primarily in the first trimester of pregnancy. After consulting about the risk of transmission of CMV to the fetus, the woman chose monthly ultrasound scans and refused amniocentesis. At 36 weeks gestation, in addition to the microcephaly already established, enlargement of the IV brain ventricle at the expense of underdevelopment of the cerebellum was noticed. Also, 2nd to 3rd stage of placenta maturity and low quantity of amniotic fluid was established. A male fetus of weight 2,890 g and height 50 cm was delivered.   The fetus was with skin petechiae and hepatosplenomegaly. Neurological examination showed no abnormalities.CONCLUSIONS: In the described case the time interval between infection and ultrasonic manifestations is more than 17 weeks. The long interval between infection and occurrence of ultrasound markers can be a good prediction sign, as it may reflect less aggressive viral infection than present in cases where similar ultrasound findings were obtained shortly after infection of the mother.

scholarly journals A STUDY TO ASSESS PREDICTIVE ROLE OF C-REACTIVE PROTEIN IN EARLY PREGNANCY AMONG WOMEN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Neeti Mahla ◽  
Mukesh Choudhary
Keyword(s):  
Early Pregnancy ◽  
Quantitative Estimation ◽  
First Trimester ◽  
Normal Pregnancy ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Predictive Role ◽  
The Difference

Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Collected samples were sent to a designated lab of our hospital. Results: The mean c-reactive protein level in cases 2.31 with min-max value ranging from 0.80-3.91mg/dl while in controls mean c-reactive protein value came to be 9.12 with min-max range from 3.21-24.16 mg/dl. The difference between the two groups is significant as p value is less than 0.001. Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies. Keywords: CRP, Pregnancy, Women

scholarly journals Role of Maternal Serum Glycodelin as Predictor of Ectopic Pregnancy in First Trimester

2018 ◽  
Vol 7 (4) ◽  
pp. 467-470
Author(s):  
Wasan Wajdi Ibrahim ◽  
Afraa Mahjoob Al-Naddawi ◽  
Hayder A. Fawzi
Keyword(s):  
Ectopic Pregnancy ◽  
Predictive Value ◽  
First Trimester ◽  
Maternal Serum ◽  
Intrauterine Pregnancy ◽  
Receiver Operator Curve Analysis ◽  
Medical City ◽  
First Trimester Of Pregnancy ◽  
Control Study

Objectives: Assessment of glycodelin (GD) as a marker for unruptured ectopic pregnancy (EP) in the first trimester of pregnancy. Materials and Methods: This case-control study was conducted during June 2016 to May 2017 in the Obstetrics and Gynecological Department of Baghdad University at Baghdad teaching hospital/medical city complex. In this study, 100 pregnant women in their first trimester of pregnancy were included after clinical and ultrasonic findings. Results: Based on the results, GD levels in EP were significantly lower than those with normal intrauterine pregnancy (1.58 ± 1.18 vs. 30.1 ± 11.9). In addition, using receiver operator curve analysis, the cut-off GD level of 9.5 and less had acceptable validity results (100% sensitivity, 100% specificity, 95% positive predictive value, 100% negative predictive value, and accuracy 100%) to predict EP. Conclusions: In general, serum GD is considered as an excellent predictor of unruptured EP.

The role of first-trimester fetal nasal bone in screening for down syndrome in the korean population

2006 ◽  
Vol 195 (6) ◽  
pp. S183
Author(s):  
Jin Hoon Chung ◽  
Jae Hyug Yang ◽  
Moon-Young Kim ◽  
Hyun Mee Ryu ◽  
Min Hoan Moon ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Korean Population ◽  
Fetal Nasal Bone

scholarly journals Screening for pre-eclampsia in the first trimester: role of maternal hemodynamics and bioimpedance in non-obese patients

2017 ◽  
Vol 50 (5) ◽  
pp. 584-588 ◽  
Author(s):  
G. Gagliardi ◽  
G. M. Tiralongo ◽  
D. LoPresti ◽  
I. Pisani ◽  
D. Farsetti ◽  
...  
Keyword(s):  
First Trimester ◽  
Obese Patients

Vitamine D en het risico op ASS

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Huub F.J. Savelkoul
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
First Trimester ◽  
Autism Spectrum ◽  
Maternal Serum ◽  
Immune Reactivity ◽  
Anti Oxidant ◽  
First Trimester Of Pregnancy ◽  
Spectrum Disorders

Autism spectrum disorders (ASD) is a heterogeneous group of behavioral disorders in which a disturbed immune reactivity can contribute to the etiology. In retrospective research we found an association between the risk to develop ASD and the month of birth with a peak in July pointing at a possible decreased exposure to sunlight during the first two semesters of pregnancy. This could point to an important role of vitamin D which has important anti-inflammatory and anti-oxidant activities and thereby regulates the proper functioning of the immune system in these individuals. Maternal serum levels of vitamin D double during the first trimester of pregnancy and therefore decreased exposure to sunlight resulting in diminished levels of vitamin D production can be an important risk factor for the development of ASD. However, there is a need for more integrated multidisciplinary studies in families where all siblings are also studied to elucidate the contribution of their genetic risk factors.

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