scholarly journals The Integrins Involved in Soybean Agglutinin-Induced Cell Cycle Alterations in IPEC-J2

2017 ◽  
Vol 40 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Li Pan ◽  
Yuan Zhao ◽  
Zhijie Yuan ◽  
Mohammed Hamdy Farouk ◽  
Shiyao Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Soybean Agglutinin ◽  
Cell Cycle Alterations

scholarly journals Infection of cells with replication deficient adenovirus induces cell cycle alterations and leads to downregulation of E2F-1

2002 ◽  
Vol 1542 (1-3) ◽  
pp. 106-115 ◽  
Author(s):  
Hartmut Kuhn ◽  
Uta Liebers ◽  
Christian Gessner ◽  
Leonid Karawajew ◽  
Velia Ruppert ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Alterations

Abstract B62: Cell cycle alterations in paired diagnosis-relapse childhood acute lymphoblastic leukemia.

2013 ◽  
Author(s):  
Roberta Bortolozzi ◽  
Giampietro Viola ◽  
Maddalena Paganin ◽  
Silvia Bresolin ◽  
Silvia Disarò ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cell Cycle Alterations

scholarly journals Unravelling the Potential Cytotoxic Effects of Metal Oxide Nanoparticles and Metal(Loid) Mixtures on A549 Human Cell Line

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 447
Author(s):  
Fernanda Rosário ◽  
Maria João Bessa ◽  
Fátima Brandão ◽  
Carla Costa ◽  
Cláudia B. Lopes ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Prolonged Exposure ◽  
Titanium Dioxide Nanoparticles ◽  
Metal Oxide Nanoparticles ◽  
A549 Cells ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Dependent Manner ◽  
Thiazolyl Blue Tetrazolium Bromide ◽  
Cell Cycle Alterations

Humans are typically exposed to environmental contaminants’ mixtures that result in different toxicity than exposure to the individual counterparts. Yet, the toxicology of chemical mixtures has been overlooked. This work aims at assessing and comparing viability and cell cycle of A549 cells after exposure to single and binary mixtures of: titanium dioxide nanoparticles (TiO2NP) 0.75–75 mg/L; cerium oxide nanoparticles (CeO2NP) 0.75–10 μg/L; arsenic (As) 0.75–2.5 mg/L; and mercury (Hg) 5–100 mg/L. Viability was assessed through water-soluble tetrazolium (WST-1) and thiazolyl blue tetrazolium bromide (MTT) (24 h exposure) and clonogenic (seven-day exposure) assays. Cell cycle alterations were explored by flow cytometry. Viability was affected in a dose- and time-dependent manner. Prolonged exposure caused inhibition of cell proliferation even at low concentrations. Cell-cycle progression was affected by TiO2NP 75 mg/L, and As 0.75 and 2.5 μg/L, increasing the cell proportion at G0/G1 phase. Combined exposure of TiO2NP or CeO2NP mitigated As adverse effects, increasing the cell surviving factor, but cell cycle alterations were still observed. Only CeO2NP co-exposure reduced Hg toxicity, translated in a decrease of cells in Sub-G1. Toxicity was diminished for both NPs co-exposure compared to its toxicity alone, but a marked toxicity for the highest concentrations was observed for longer exposures. These findings prove that joint toxicity of contaminants must not be disregarded.

scholarly journals Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191178 ◽  
Author(s):  
Erin J. Vanzyl ◽  
Kayleigh R. C. Rick ◽  
Alex B. Blackmore ◽  
Erin M. MacFarlane ◽  
Bruce C. McKay
Keyword(s):  
Cell Cycle ◽  
Flow Cytometric Analysis ◽  
Flow Cytometric ◽  
Cell Cycle Alterations

Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types

2011 ◽  
Vol 13 (6) ◽  
pp. 1831 ◽  
Author(s):  
Vanessa Valdiglesias ◽  
Blanca Laffon ◽  
Eduardo Pásaro ◽  
Josefina Méndez
Keyword(s):  
Cell Cycle ◽  
Okadaic Acid ◽  
Human Cell ◽  
Morphological Changes ◽  
Cell Types ◽  
Cell Cycle Alterations

In vitro short-term exposure to air pollution PM2.5-0.3 induced cell cycle alterations and genetic instability in a human lung cell coculture model

2016 ◽  
Vol 147 ◽  
pp. 146-158 ◽  
Author(s):  
Imane Abbas ◽  
Anthony Verdin ◽  
Fabienne Escande ◽  
Françoise Saint-Georges ◽  
Fabrice Cazier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Air Pollution ◽  
Genetic Instability ◽  
Human Lung ◽  
Short Term ◽  
Short Term Exposure ◽  
Cell Cycle Alterations ◽  
Coculture Model
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