scholarly journals HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

2015 ◽  
Vol 38 (4) ◽  
pp. 343-348 ◽  
Author(s):  
Todd J. Cohen ◽  
Moon-Chang Choi ◽  
Meghan Kapur ◽  
Vitor A. Lira ◽  
Zhen Yan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Specific Gene ◽  
Specific Gene Expression

scholarly journals Effect of muscle-fiber type on glycogenin-1 gene expression and its relationship with the glycolytic potential and pH of pork

2013 ◽  
Vol 12 (3) ◽  
pp. 3383-3390 ◽  
Author(s):  
S.-H. Zhang ◽  
L. Zhu ◽  
Z.-H. Wu ◽  
Y. Zhang ◽  
G.-Q. Tang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Glycolytic Potential

scholarly journals Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

2011 ◽  
Vol 359 (2) ◽  
pp. 303-320 ◽  
Author(s):  
Anne-Françoise Richard ◽  
Josiane Demignon ◽  
Iori Sakakibara ◽  
Julien Pujol ◽  
Maryline Favier ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Mouse Embryogenesis

The calcineurin-NFAT pathway and muscle fiber-type gene expression

2000 ◽  
Vol 279 (4) ◽  
pp. C915-C924 ◽  
Author(s):  
Steven J. Swoap ◽  
R. Bridge Hunter ◽  
Eric J. Stevenson ◽  
Heather Mitchell Felton ◽  
Nilesh V. Kansagra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fiber Type ◽  
Fast Muscle ◽  
C2c12 Myotubes ◽  
Specific Gene ◽  
Activated T Cells ◽  
Adult Skeletal Muscle ◽  
Specific Gene Expression ◽  
Expression Plasmids

To test for a role of the calcineurin-NFAT (nuclear factor of activated T cells) pathway in the regulation of fiber type-specific gene expression, slow and fast muscle-specific promoters were examined in C2C12 myotubes and in slow and fast muscle in the presence of calcineurin or NFAT2 expression plasmids. Overexpression of active calcineurin in myotubes induced both fast and slow muscle-specific promoters but not non-muscle-specific reporters. Overexpression of NFAT2 in myotubes did not activate muscle-specific promoters, although it strongly activated an NFAT reporter. Thus overexpression of active calcineurin activates transcription of muscle-specific promoters in vitro but likely not via the NFAT2 transcription factor. Slow myosin light chain 2 (MLC2) and fast sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1) reporter genes injected into rat soleus (slow) and extensor digitorum longus (EDL) (fast) muscles were not activated by coinjection of activated calcineurin or NFAT2 expression plasmids. However, an NFAT reporter was strongly activated by overexpression of NFAT2 in both muscle types. Calcineurin and NFAT protein expression and binding activity to NFAT oligonucleotides were different in slow vs. fast muscle. Taken together, these results indicate that neither calcineurin nor NFAT appear to have dominant roles in the induction and/or maintenance of slow or fast fiber type in adult skeletal muscle. Furthermore, different pathways may be involved in muscle-specific gene expression in vitro vs. in vivo.

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