scholarly journals Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer’s Disease

2015 ◽  
Vol 38 (9) ◽  
pp. 796-805 ◽  
Author(s):  
Hyeon-Joong Kim ◽  
Eun-Joo Shin ◽  
Byung-Hwan Lee ◽  
Sun-Hye Choi ◽  
Seok-Won Jung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Oral Administration ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Model Of Alzheimer’S Disease ◽  
Β Protein

Passage of amyloid β protein antibody across the blood–brain barrier in a mouse model of Alzheimer’s disease

Peptides ◽  
2002 ◽  
Vol 23 (12) ◽  
pp. 2223-2226 ◽  
Author(s):  
William A. Banks ◽  
Brie Terrell ◽  
Susan A. Farr ◽  
Sandra M. Robinson ◽  
Naoko Nonaka ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Protein ◽  
Blood Brain ◽  
Model Of Alzheimer’S Disease ◽  
Β Protein

scholarly journals Distinguishing Amyloid β-Protein in a Mouse Model of Alzheimer’s Disease by Label-Free Vibrational Imaging

Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 365
Author(s):  
Shaowei Li ◽  
Ziyi Luo ◽  
Renlong Zhang ◽  
Hao Xu ◽  
Ting Zhou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Β ◽  
Basic Research ◽  
Amyloid Β Protein ◽  
Label Free ◽  
Model Of Alzheimer’S Disease ◽  
Β Protein ◽  
Anti Stokes

Due to the increase in the average age of humans, Alzheimer’s disease (AD) has become one of the disorders with the highest incidence worldwide. Abnormal amyloid β protein (Aβ) accumulation is believed to be the most common cause of AD. Therefore, distinguishing the lesion areas can provide clues for AD diagnosis. Here, we present an optical spectroscopy and imaging approach based on coherent anti-Stokes Raman scattering (CARS). Label-free vibrational imaging of Aβ in a mouse model of AD was performed to distinguish the lesion areas by studying the spectra of regions with and without Aβ plaques. Raman spectra in Aβ and non-Aβ regions exhibited a specific difference in the intensity ratio of the wave peaks detected at 2850 and 2930 cm–1. In the non-Aβ region, the ratio of the peak intensity at 2850 cm–1 to that at 2930 cm–1 was approximately 1, whereas that in the Aβ region was 0.8. This label-free vibrational imaging may provide a new method for the clinical diagnosis and basic research of AD.

Normal Production of the Amyloid β-Protein and the Pathogenesis of Alzheimer’s Disease

1995 ◽  
pp. 95-97
Author(s):  
Dennis J. Selkoe ◽  
Christian Haass ◽  
Michael Schlossmacher ◽  
Albert Hung ◽  
Martin Citron ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Normal Production

scholarly journals Effects of γ-Secretase Inhibition on the Amyloid β Isoform Pattern in a Mouse Model of Alzheimer’s Disease

2009 ◽  
Vol 6 (5-6) ◽  
pp. 258-262 ◽  
Author(s):  
Erik Portelius ◽  
Bin Zhang ◽  
Mikael K. Gustavsson ◽  
Gunnar Brinkmalm ◽  
Ann Westman-Brinkmalm ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Β ◽  
Model Of Alzheimer’S Disease
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