scholarly journals Therapeutic Strategy for the Prevention of Pseudorabies Virus Infection in C57BL/6 Mice by 3D8 scFv with Intrinsic Nuclease Activity

2015 ◽  
Vol 38 (9) ◽  
pp. 773-780 ◽  
Author(s):  
Gunsup Lee ◽  
SeungChan Cho ◽  
Phuong Mai Hoang ◽  
Dongjun Kim ◽  
Yongjun Lee ◽  
...  
Keyword(s):  
Virus Infection ◽  
Therapeutic Strategy ◽  
Pseudorabies Virus ◽  
Nuclease Activity ◽  
3D8 Scfv

scholarly journals Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus

2000 ◽  
Vol 76 (1-2) ◽  
pp. 125-135 ◽  
Author(s):  
M.G.M De Bruin ◽  
J.N Samsom ◽  
J.J.M Voermans ◽  
E.M.A van Rooij ◽  
Y.E De Visser ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Pseudorabies Virus ◽  
Respiratory Syndrome Virus

Probabilistic Modeling of Pseudorabies Virus Infection in a Neural Circuit

2018 ◽  
Vol 25 (11) ◽  
pp. 1231-1246
Author(s):  
Siamak K. Sorooshyari ◽  
Matthew P. Taylor ◽  
H. Vincent Poor
Keyword(s):  
Virus Infection ◽  
Pseudorabies Virus ◽  
Neural Circuit ◽  
Probabilistic Modeling

scholarly journals Erratum

2012 ◽  
Vol 24 (1) ◽  
pp. 246-246
Keyword(s):  
Virus Infection ◽  
Inclusion Body ◽  
Pseudorabies Virus ◽  
Intranuclear Inclusion ◽  
Hunting Dogs ◽  
Intracytoplasmic Inclusion ◽  
Intracytoplasmic Inclusion Body

JVDI 23:915–923 (September 2011) In the article entitled “Pseudorabies virus infection in Oklahoma hunting dogs” by Sarah D. Cramer et al., on page 918 in the legend to Figure 2, the legend should refer to an “intranuclear” inclusion body instead of an “intracytoplasmic” inclusion body.

scholarly journals Human encephalitis caused by pseudorabies virus infection: a case report

2020 ◽  
Vol 26 (3) ◽  
pp. 442-448 ◽  
Author(s):  
Di Wang ◽  
Xiaogen Tao ◽  
Mingming Fei ◽  
Jian Chen ◽  
Wei Guo ◽  
...  
Keyword(s):  
Case Report ◽  
Virus Infection ◽  
Pseudorabies Virus

scholarly journals Avian influenza virus transmission is suppressed in chickens fed Lactobacillus paracasei expressing the 3D8 single-chain variable fragment protein

2019 ◽  
Vol 67 (4) ◽  
pp. 610-618
Author(s):  
Hoonsung Choi ◽  
Sang In Lee ◽  
Shanmugam Sureshkumar ◽  
Mi-Hyang Jeon ◽  
Jeom Sun Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Nuclease Activity ◽  
Lactobacillus Paracasei ◽  
Post Inoculation ◽  
Single Chain Variable Fragment ◽  
Single Chain ◽  
Contact Transmission ◽  
3D8 Scfv

The 3D8 single-chain variable fragment (scFv) is a mini-antibody sequence with independent nuclease activity that shows antiviral effects against all types of viruses in chickens and mice. In this study, chickens were treated daily with an oral dose of 109 CFU Lactobacillus paracasei (L. paracasei) expressing either a secreted or anchored 3D8 scFv for three weeks. After L. paracasei administration, the chickens were challenged with avian influenza virus (AIV). From each experimental group, three chickens were directly infected with 100 µL of 107.5 EID50/mL H9N2 AIV and seven chickens were indirectly challenged through contact transmission. oropharyngeal and cloacal swab samples were collected at 3, 5, 7, and 9 days post-inoculation (dpi) from AIV-challenged chickens, AIV Shedding titres were measured by quantitative real-time PCR. Contact transmission in the chickens that were fed 3D8 scFv-secreting L. paracasei showed a significant reduction in viral shedding when compared with other groups. These results suggest that L. paracasei secreting 3D8 provides a basis for the development of ingestible antiviral probiotics with activity against AIV.

Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins

Vaccine ◽  
2005 ◽  
Vol 23 (26) ◽  
pp. 3483-3491 ◽  
Author(s):  
Daniel Dory ◽  
Anne-Marie Torché ◽  
Véronique Béven ◽  
Philippe Blanchard ◽  
Christophe Loizel ◽  
...  
Keyword(s):  
Virus Infection ◽  
Pseudorabies Virus ◽  
Low Dose ◽  
Single Injection ◽  
Effective Protection
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