scholarly journals Ginseng Gintonin Activates the Human Cardiac Delayed Rectifier K+ Channel: Involvement of Ca2+/Calmodulin Binding Sites

2014 ◽  
Vol 37 (9) ◽  
pp. 656-663 ◽  
Author(s):  
Sun-Hye Choi ◽  
Byung-Hwan Lee ◽  
Hyeon-Joong Kim ◽  
Seok-Won Jung ◽  
Hyun-Sook Kim ◽  
...  
Keyword(s):  
Binding Sites ◽  
K Channel ◽  
Delayed Rectifier ◽  
Calmodulin Binding ◽  
Cardiac Delayed Rectifier

Molecular Analysis of a Binding Site for Quinidine in a Human Cardiac Delayed Rectifier K + Channel

1996 ◽  
Vol 78 (6) ◽  
pp. 1105-1114 ◽  
Author(s):  
Sarita W. Yeola ◽  
Tom C. Rich ◽  
Vic N. Uebele ◽  
Michael M. Tamkun ◽  
Dirk J. Snyders
Keyword(s):  
Binding Site ◽  
Molecular Analysis ◽  
K Channel ◽  
Delayed Rectifier ◽  
Cardiac Delayed Rectifier

Evidence for multiple antiarrhythmic binding sites on the cardiac rapidly activating delayed rectifier K+ channel

1995 ◽  
Vol 34 (4) ◽  
pp. 376-380 ◽  
Author(s):  
Christopher C. Chadwick ◽  
Douglas S. Krafte ◽  
Bernard O'Connor ◽  
Walter A. Volberg ◽  
Alan M. Ezrin ◽  
...  
Keyword(s):  
Binding Sites ◽  
K Channel ◽  
Delayed Rectifier

scholarly journals Fast inactivation causes rectification of the IKr channel.

1996 ◽  
Vol 107 (5) ◽  
pp. 611-619 ◽  
Author(s):  
P S Spector ◽  
M E Curran ◽  
A Zou ◽  
M T Keating ◽  
M C Sanguinetti
Keyword(s):  
Outward Current ◽  
K Channel ◽  
Delayed Rectifier ◽  
Fast Inactivation ◽  
Time Constants ◽  
Recovery From Inactivation ◽  
Current Voltage ◽  
Voltage Dependent ◽  
Cardiac Delayed Rectifier ◽  
Cytoplasmic Side

The mechanism of rectification of HERG, the human cardiac delayed rectifier K+ channel, was studied after heterologous expression in Xenopus oocytes. Currents were measured using two-microelectrode and macropatch voltage clamp techniques. The fully activated current-voltage (I-V) relationship for HERG inwardly rectified. Rectification was not altered by exposing the cytoplasmic side of a macropatch to a divalent-free solution, indicating this property was not caused by voltage-dependent block of outward current by Mg2+ or other soluble cytosolic molecules. The instantaneous I-V relationship for HERG was linear after removal of fast inactivation by a brief hyperpolarization. The time constants for the onset of and recovery from inactivation were a bell-shaped function of membrane potential. The time constants of inactivation varied from 1.8 ms at +50 mV to 16 ms at -20 mV; recovery from inactivation varied from 4.7 ms at -120 mV to 15 ms at -50 mV. Truncation of the NH2-terminal region of HERG shifted the voltage dependence of activation and inactivation by +20 to +30 mV. In addition, the rate of deactivation of the truncated channel was much faster than wild-type HERG. The mechanism of HERG rectification is voltage-gated fast inactivation. Inactivation of channels proceeds at a much faster rate than activation, such that no outward current is observed upon depolarization to very high membrane potentials. Fast inactivation of HERG and the resulting rectification are partly responsible for the prolonged plateau phase typical of ventricular action potentials.

Class III Antiarrhythmic Drugs Block HERG, a Human Cardiac Delayed Rectifier K + Channel

1996 ◽  
Vol 78 (3) ◽  
pp. 499-503 ◽  
Author(s):  
Peter S. Spector ◽  
Mark E. Curran ◽  
Mark T. Keating ◽  
Michael C. Sanguinetti
Keyword(s):  
Antiarrhythmic Drugs ◽  
K Channel ◽  
Delayed Rectifier ◽  
Class Iii ◽  
Cardiac Delayed Rectifier

scholarly journals Insensitivity of cardiac delayed-rectifier I Kr to tyrosine phosphorylation inhibitors and stimulators

2006 ◽  
Vol 148 (5) ◽  
pp. 724-731 ◽  
Author(s):  
Sergey Missan ◽  
Pavel Zhabyeyev ◽  
Paul Linsdell ◽  
Terence F McDonald
Keyword(s):  
Tyrosine Phosphorylation ◽  
Delayed Rectifier ◽  
Cardiac Delayed Rectifier

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)

2015 ◽  
Vol 89 ◽  
pp. 335-348 ◽  
Author(s):  
Marianne Agsten ◽  
Sabine Hessler ◽  
Sandra Lehnert ◽  
Tilmann Volk ◽  
Andrea Rittger ◽  
...  
Keyword(s):  
Delayed Rectifier ◽  
Cardiac Delayed Rectifier
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