scholarly journals Primary hyperparathyroidism: case report

2021 ◽  
Vol 14 (2) ◽  
pp. 21-24
Author(s):  
Leila M. Farkhutdinova ◽  
Salam Yu. Mohammad ◽  
Ildar M. Yamaev ◽  
Bulat I. Abdulguzhin
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Severe Form ◽  
Laboratory Studies ◽  
Mineral Density ◽  
Severe Osteoporosis ◽  
Multiple Fractures ◽  
Endocrine Diseases ◽  
The Russian Federation ◽  
The Common

Primary hyperparathyroidism is one of the common endocrine diseases, which is an actual medical and social problem. Bone disorders are the most common manifestations of primary hyperparathyroidism and are characterized by increased bone metabolism with a progressive decrease in mineral density and a high risk of fractures. In the Russian Federation, most cases are manifest forms of the disease (70%), which is mainly due to the low level of diagnosis, including due to the lack of awareness of doctors. At the same time, timely detection of the disease is based on relatively accessible laboratory studies, characterized by elevated levels of calcium and parathyroid hormone in the blood, and ultrasound and scintigraphy in most cases provide visualization of the paraadenoma. A clinical case of a severe form of primary hyperparathyroidism, the late diagnosis of which caused the development of severe osteoporosis with multiple fractures, is considered. The presented case indicates that an important role in the timely detection of the disease belongs to the analysis of the clinical picture.

scholarly journals Primary Hyperparathyroidism: Modern Conception and Clinical Observation

2020 ◽  
Vol 10 (2) ◽  
pp. 94-101
Author(s):  
L. M. Farkhutdinova
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Clinical Manifestations ◽  
Premature Death ◽  
Developed Countries ◽  
Severe Form ◽  
Mineral Density ◽  
Target Organs ◽  
Increased Risk

The article is devoted to one of the actual medical and social problems — primary hyperparathyroidism, the late diagnosis of which leads to the development of severe complications and an increased risk of premature death. Unlike developed countries, where 80% of cases are represented by mild forms of the disease, in the Russian Federation this indicator does not exceed 30%, while 70% are manifest forms. Widespread awareness of doctors of various specialties in the diagnosis of parathyroid adenoma is necessary for the timely detection of the disease. The article reflects the main stages of the study of the disease, the pathogenesis of the clinical manifestations of primary hyperparathyroidism, the classic symptoms of which are changes in the target organs of the parathyroid hormone — bone tissue, urinary system and gastrointestinal tract, is considered. Bone disorders are the most common manifestation of hyperparathyroidism and are characterized by increased bone metabolism with a progressive decrease in bone mineral density. Typical changes in the kidneys include nephrolithiasis and nephrocalcinosis, causing the formation of renal failure. Gastrointestinal signs of hyperparathyroidism are erosion and ulcers of the stomach and duodenum, prone to bleeding, recurrent pancreatitis. Diagnosis of the disease is based on laboratory results, characterized by elevated levels of calcium and parathyroid hormone in the blood. Visualization of the paradenomas in most cases is provided by ultrasound and scintigraphy. Removal of parathyroid adenoma is the most effective treatment. A clinical case of a severe form of the disease is presented, indicating an urgent need to take measures to solve the problem of primary hyperparathyroidism.

A CASE OF PRIMARY HYPERPARATHYROIDISM

Vestnik ◽  
2021 ◽  
pp. 195-197
Author(s):  
М.Е. Рамазанов ◽  
Р.Б. Базарбекова ◽  
А.К. Досанова ◽  
Ж.С. Шерияздан ◽  
У.З. Апбасова ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Endocrine Diseases ◽  
Hypercalcemic Crisis ◽  
Benign Adenoma ◽  
Menopausal Women ◽  
High Incidence ◽  
The Common ◽  
The Given ◽  
Over 40 Years ◽  
Over Time

Первичный гиперпаратиреоз - одно из распространенных, но трудно диагностируемых в реальной клинической практике эндокринных заболеваний у взрослых. Актуальность данной публикации определяется высокой частотой заболевания у лиц старше 40 лет. Риск его возникновения у людей 40-50 лет достигает 2%. Имеются все основания считать, что данный показатель с течением времени будет увеличиваться, поскольку согласно прогнозам отдела народонаселения Организации Объединённых Наций от 2001г. удельный вес пожилых людей к 2050г. в мире достигнет 21% в сравнении с 10% в 2000г. Особенно подвержены первичному гиперпаратиреозу женщины менопаузального возраста, у которых заболевание встречается с частотой 1:500. В большинстве случаев первичный гиперпаратиреоз возникает вследствие солитарной доброкачественной аденомы паращитовидных желез. В данной статье представлен случай аденомы паращитовидной железы с развитием гиперкальциемического криза у женщины в возрасте 49 лет, выбор дальнейшей тактики ведения - консервативное или оперативное лечение, а также рекомендации по наблюдению в динамике. Приведенный случай будет интересен специалистам как терапевтического, так и хирургического профиля. Primary hyperparathyroidism is one of the common but difficult to diagnose endocrine diseases in adults in real clinical practice. The relevance of this publication is determined by the high incidence of the disease in persons over 40 years of age. The risk of its occurrence in people 40-50 years old reaches 2%. There is every reason to believe that this figure will increase over time, since according to the projections of the UN Population Division for 2001, the proportion of elderly people in the world will reach 21% by 2050, compared with 10% in 2000. Menopausal women are especially susceptible to primary hyperparathyroidism which the disease occurs with a frequency of 1: 500. In most cases, primary hyperparathyroidism occurs due to solitary benign adenoma of the parathyroid glands. This article presents a case of parathyroid adenoma with the development of a hypercalcemic crisis in a woman aged 49 years, the choice of further management tactics - conservative or surgical treatment, as well as recommendations for monitoring over time. The given case will be of interest to specialists of both therapeutic and surgical profile.

scholarly journals Safety of belimumab in association with denosumab in a patient affected by Lupus Erythematosus: a case report

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Marco Scarati ◽  
Simone Parisi ◽  
Richard Borrelli ◽  
Maria Bruzzone ◽  
Marta Priora ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Clinical Case ◽  
Fragility Fractures ◽  
Underlying Disease ◽  
Mineral Density ◽  
Viable Option ◽  
Severe Osteoporosis ◽  
Combined Administration ◽  
Immunologic Disease ◽  
Chronic Autoimmune Disease

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by multisystemic involvement. Owing to multifactorial etiologies, low bone mineral density (BMD) osteoporosis (OP) and fragility fractures (FFx) have been very frequently documented in these patients. Appropriate treatments to minimize underlying immunologic disease activity remain mandatory, and the development of strategies to prevent and treat important complications as osteoporosis is needed.We present the clinical case of a female SLE patient treated simultaneously with belimumab (anti-BLyS) for the underlying disease, and denosumab (anti-RANKL) for concomitant severe osteoporosis. As these monoclonal antibodies have been recently introduced into the market, their combination has not been reported in literature yet. In this case, the combined administration proved a viable option for a SLE patient with osteoporosis and bisphosphonates contraindications.

scholarly journals Registries of parathyroid glands diseases in the Russian Federation

2021 ◽  
Vol 67 (4) ◽  
pp. 4-7
Author(s):  
N. G. Mokrysheva ◽  
E. V. Kovaleva ◽  
A. K. Eremkina
Keyword(s):  
Diabetes Mellitus ◽  
Primary Hyperparathyroidism ◽  
Patient Reported Outcomes ◽  
Large Scale ◽  
Epidemiological Data ◽  
Parathyroid Glands ◽  
Basic Information ◽  
Endocrine Diseases ◽  
Patient Reported ◽  
The Russian Federation

The most important and effective way to organize nationwide the healthcare, as well as monitoring and routing for patients with endocrine diseases, is the creation of an unified medical record (Endocard). The Endocard is also aimed at maximizing the opportunity for professionals and researchers on various scientific issues. Registries are the potential informational and analytical platform to achieve this goal. They include the basic information on the epidemiological and clinical features of the most severe diseases such as diabetes mellitus. Given the lack of large-scale epidemiological data on the parathyroid glands pathology — primary hyperparathyroidism and hypoparathyroidism — the registers of these diseases that collects a common dataset and clinician and patient reported outcomes are of particular interest.

scholarly journals А clinical case of mumps incurred in orhiepididimita a teenager

2020 ◽  
Vol 11 (6) ◽  
pp. 71-78
Author(s):  
Dmitry O. Ivanov ◽  
Vladimir N. Timchenko ◽  
Lyubov M. Pochinyaeva ◽  
Maria A. Shakmaeva ◽  
Tatyana A. Kaplina ◽  
...  
Keyword(s):  
Clinical Case ◽  
Conservative Therapy ◽  
Severe Form ◽  
Pathological Process ◽  
Testicular Atrophy ◽  
Laboratory Diagnostics ◽  
Older Children ◽  
Treatment Standards ◽  
The Russian Federation ◽  
Testicular Inflammation

Mumps currently is a vaccine-preventable infections. However, mumps still remains an urgent problem all over the world, due to periodic increases in the incidence in older children (including the vaccinated ones against this infection), in adults (the disease often does not go smoothly with involving various organs in the pathological process and systems). The literature describes the various adverse effects of male mumps, including infertility, testicular atrophy, testicular tumors, impotence, gynecomastia, etc. The article provides information on the incidence of mumps in the Russian Federation and St. Petersburg, the clinical manifestation of the infection. It was noted that in adolescent boys and men, the presence of orchitis (orchoepididymitis) is a frequent symptom of the disease. It is shown in the article, that testicular inflammation rate increases with age of patients. A brief description of modern methods of laboratory diagnostics and therapy is given in accordance with clinical recommendations and treatment standards. A clinical case of mumps, combined severe form (mumps + orchoepididymitis), in a 17-year-old boy is presented in this article. The features of the course of the disease, the results of laboratory and instrumental examination and treatment have been analyzed in this item. Conservative therapy (antiviral and antibacterial) of mumps, as well as timely surgical treatment of orchoepididymitis, led to a complete clinical and laboratory recovery of the patient.

scholarly journals Primary Hyperparathyroidism: Modern Conception and Clinical Observation

2020 ◽  
Vol 10 (2) ◽  
pp. 94-101
Author(s):  
L. M. Farkhutdinova
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Clinical Manifestations ◽  
Premature Death ◽  
Developed Countries ◽  
Severe Form ◽  
Mineral Density ◽  
Target Organs ◽  
Increased Risk

The article is devoted to one of the actual medical and social problems — primary hyperparathyroidism, the late diagnosis of which leads to the development of severe complications and an increased risk of premature death. Unlike developed countries, where 80% of cases are represented by mild forms of the disease, in the Russian Federation this indicator does not exceed 30%, while 70% are manifest forms. Widespread awareness of doctors of various specialties in the diagnosis of parathyroid adenoma is necessary for the timely detection of the disease. The article reflects the main stages of the study of the disease, the pathogenesis of the clinical manifestations of primary hyperparathyroidism, the classic symptoms of which are changes in the target organs of the parathyroid hormone — bone tissue, urinary system and gastrointestinal tract, is considered. Bone disorders are the most common manifestation of hyperparathyroidism and are characterized by increased bone metabolism with a progressive decrease in bone mineral density. Typical changes in the kidneys include nephrolithiasis and nephrocalcinosis, causing the formation of renal failure. Gastrointestinal signs of hyperparathyroidism are erosion and ulcers of the stomach and duodenum, prone to bleeding, recurrent pancreatitis. Diagnosis of the disease is based on laboratory results, characterized by elevated levels of calcium and parathyroid hormone in the blood. Visualization of the paradenomas in most cases is provided by ultrasound and scintigraphy. Removal of parathyroid adenoma is the most effective treatment. A clinical case of a severe form of the disease is presented, indicating an urgent need to take measures to solve the problem of primary hyperparathyroidism.

scholarly journals Use of teriparatide in treatment of severe osteoporosis in geriatric practice: a clinical case review

2020 ◽  
Vol 16 (4) ◽  
pp. 80-89
Author(s):  
Ekaterina N. Dudinskaya ◽  
Olga N. Tkacheva ◽  
Liubov V. Machekhina ◽  
Valentina S. Ostapenko ◽  
Natalya V. Brailova
Keyword(s):  
Clinical Case ◽  
Osteoporotic Fractures ◽  
Case Review ◽  
Mineral Density ◽  
Severe Osteoporosis ◽  
Treatment Of Osteoporosis ◽  
Drug Of Choice ◽  
Age Related ◽  
Risk Of Falls ◽  
Anabolic Therapy

Elderly and senile people are characterized by a high prevalence of osteoporosis, which, in turn, increases the risk of fractures, including the repeated ones. Fractures in osteoporosis are an extremely unfavorable complication of the disease, leading to catastrophic consequences in old age. The prevalence of osteoporotic fractures progressively increases with age. At present, the cumulative frequency of hip fractures in women over 80 is about 30%. The proportion of vertebral fractures in women older than 80 years is up to 40% of all vertebral osteoporotic fractures. Despite the tremendous successes achieved in the diagnosis and treatment of osteoporosis, the disease itself and related fractures remain a serious medical, economic and social problem. Prevention of recurrent fractures in geriatric patients is a system of preventive, rehabilitative and therapeutic measures aimed at reducing the risk of falls, choosing an effective therapy, and reducing the risk of recurring fractures. A serious problem in the treatment of osteoporosis in older people is the inefficiency of the antiresorptive therapy due to an age-related decrease in bone formation. There are frequent cases of a continuing decrease in bone density, the occurrence of repeated fractures during ongoing therapy of osteoporosis. Often the therapy of choice in this case is bone-anabolic therapy with teriparatide, which allows one to achieve good results in the accumulation of bone mineral density. In this article, we will present the clinical case of an elderly patient with severe osteoporosis, in which teriparatide became the drug of choice.

scholarly journals Primary hyperparathyroidism with PTH values within the reference range: clinical case of a patient with recurrent nephrolithiasis

2019 ◽  
Vol 16 (3) ◽  
pp. 104-109
Author(s):  
Olga O. Golounina ◽  
Gyuzel E. Runova ◽  
Valentin V. Fadeyev ◽  
Anna S. Pogorelova ◽  
Gilyana V. Boldyreva
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Serum Levels ◽  
Mineral Density ◽  
Endocrine Disease ◽  
Patient Complaints ◽  
Calcium Phosphorus ◽  
Excessive Secretion ◽  
Recurrent Nephrolithiasis

Hyperparathyroidism is an endocrine disease characterized by excessive secretion of parathyroid hormone (PTH) by the parathyroid glands. Primary hyperparathyroidism (PHPT) can be diagnosed biochemically with the combination of hypercalcemia and upper-normal or elevated levels of PTH. There are few descriptions of PHPT with normal intact PTH secretion in the literature. The incidence of PHPT among patients with recurrent urolithiasis is 28%. We present a clinical case of diagnosing PHPT in a 64-year-old female patient with rare variant of the disease. Before establishing the diagnosis, the main patient complaints were long-term recurrent nephrolithiasis and nephrocalcinosis. Surgical treatment made it possible to achieve rapid normalization of biochemical parameters of calcium-phosphorus metabolism, increase bone mineral density in the lumbar spine, improve the general condition of the patient. This clinical case demonstrates errors and late diagnosis of PHPT associated with poor knowledge of the manifestations of hyperparathyroidism and its masks. The authors recommend to determine the concentrations of total calcium, albumin, serum levels of PTH in patients with clinical picture of PHPT, in order to exclude the disease.

scholarly journals A clinical case of combined differentiated thyroid cancer and primary hyperparathyroidism: the complexity of topical differential diagnosis

2019 ◽  
Vol 65 (4) ◽  
pp. 243-250
Author(s):  
Konstantin Yu. Slashchuk ◽  
Mikhail V. Degtyarev ◽  
Sergey S. Serzhenko ◽  
Pavel O. Rumyantsev ◽  
Marina S. Sheremeta ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Differentiated Thyroid Cancer ◽  
Clinical Case ◽  
Adult Population ◽  
Parathyroid Tissue ◽  
Surgical Removal ◽  
Urgent Problem ◽  
Endocrine Diseases ◽  
Topical Diagnosis ◽  
Sporadic Primary Hyperparathyroidism

In recent years, the understanding of the epidemiology, symptoms and strategies for managing patients with hyperparathyroidism has changed significantly. The most common cases in clinical practice are of sporadic primary hyperparathyroidism, which today ranks third in prevalence among endocrine diseases (the frequency of occurrence in the adult population is, on average, 12%). In primary hyperparathyroidism, solitary parathyroid adenoma is detected in up to 85% of all cases. The only treatment is radical surgical removal of pathologically altered parathyroid tissue. Early diagnosis and treatment of hyperparathyroidism makes it possible to avoid severe lesions of the skeletal bones and visceral organs. A diagnostically challenging clinical case of a combined onco-endocrine pathology in a 70-year-old patient is presented. The main difficulties in the initial diagnosis were associated with the absence of pathognomonic symptoms of the disease, which was often completely asymptomatic. The most urgent problem appears to be the topical diagnosis of pathologically altered parathyroid glands. Therefore, there is a need to develop an algorithm for the combining and sequential use of existing medical imaging methods.

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