Hypoglycemia in neonates: a review of the literature and a case report

2019 ◽  
Vol 65 (4) ◽  
pp. 251-262
Author(s):  
Tatiana E. Taranushenko ◽  
Natalia G. Kiseleva ◽  
Olga V. Lazareva ◽  
Irina I. Kalygnaja
Keyword(s):  
Case Report ◽  
Blood Glucose ◽  
Neonatal Period ◽  
Review Of The Literature ◽  
Pediatric Endocrinology ◽  
Neonatal Hypoglycemia ◽  
Brain Neurons ◽  
Carbohydrate Homeostasis ◽  
Main Factors

Hypoglycemia in the neonatal period is one of the urgent problems of pediatric endocrinology. The main factors that lead to disruption of carbohydrate homeostasis are generally known, but the issues of neonatal hypoglycemia continue to be actively studied. In the last few years, the effect of low blood glucose on brain neurons has been studied, the issues of glycemia monitoring in the first days of life have been outlined, and strategies for managing newborns with hypoglycemic syndrome are being discussed.

Transformation of a non-secretory neuroendocrine tumor to insulinoma after treatment with Sunitinib: A case report and review of the literature

2018 ◽  
Vol 25 (6) ◽  
pp. 1516-1519 ◽  
Author(s):  
Todd Clover ◽  
Amrou Abdelkader ◽  
Guru Subramanian Guru Murthy
Keyword(s):  
Case Report ◽  
Blood Glucose ◽  
Neuroendocrine Tumor ◽  
Case Series ◽  
Epigenetic Changes ◽  
Review Of The Literature ◽  
Lower Blood Glucose ◽  
Lower Blood ◽  
Cancer Phenotype ◽  
Neuroendocrine Cancers

We report a case of a non-secretory neuroendocrine tumor which transformed into an insulin secreting tumor after treatment with Sunitinib. To our knowledge, this has only been described in three other cases worldwide. Previously reported case series find transformation of non-secretory neuroendocrine cancers into secretory lesions occurs in 3.4–6.8% of cases. Sunitinib is known to have the potential to lower blood glucose and induce epigenetic changes in cells of various types. We hypothesize that the mechanism for Sunitinib-induced transformation in cancer phenotype is through epigenetic changes in DNA expression within the tumor cells.

scholarly journals Neonatal hypoglycemia in children with risk factors

2022 ◽  
pp. 80-84
Author(s):  
E. V. Antsiferova ◽  
T. E. Taranushenko ◽  
N. G. Kiseleva ◽  
E. A. Belyaeva ◽  
T. I. Donskaya
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Blood Glucose ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Large Body ◽  
Neonatal Hypoglycemia ◽  
Intrauterine Growth ◽  
Early Neonatal Period

Objective: The analysis of clinical-laboratory peculiarities and the dynamics of glycemia clarifying the terms of blood glucose stabilization during the early neonatal period in children having risk factors of the development of such state.Methods: Open, retrospective , continuous, single-center study was conducted. It was aimed at getting preliminary data that is important for planning further tactics of examining newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation).The target group of the survey included 522 newborns of both genders in the early neonatal period (from 0 to 7 days of life).Results: There is data on the frequency of first indicated hypoglycemia in newborns having risk factors of the development of such state, clinicallaboratory peculiarities, the dynamics of glycemia during early neonatal period, and also the period of blood glucose stabilization (the age of reaching normoglycemia). Neonatal hypoglycemia was detected in 40.2% of examined children. Laboratory manifestation during the first day of life was noticed 62.9% of cases with the further normalization of glucose level in blood in 24 hours in 73.3% of newborns. Significant reduction of blood glucose was observed in 54.8% of cases requiring hypoglycemia therapy with parenteral prescription of 10% glucose solution. Hypoglycemia jugulated against oral correction of 5% glucoses solution in 40.5 % of cases. 4.8% of children got the level of glucose stabilized after introduction of supplementary feeding.Conclusion: The results of the newborns having risk factors on hypoglycemia development (kids having large body weight at birth, children whose mothers have diabetes, newborns having intrauterine growth retardation) examinations are presented. The peculiarities of neonatal hypoglycemia are: the absence of a typical clinical symptoms among 89% of children. Asymptomatic course of hypoglycemia confirms the importance and necessity of glycemia monitoring in the early neonatal period in order to conduct timely and adequate therapy.

scholarly journals Transient neonatal diabetes or neonatal hyperglycaemia: A case report

2013 ◽  
Vol 40 (2) ◽  
pp. 192-194
Author(s):  
TO Obasa ◽  
OO Adesiyun ◽  
OA Mokuolu
Keyword(s):  
Weight Loss ◽  
Case Report ◽  
Blood Glucose ◽  
Neonatal Period ◽  
Neonatal Morbidity ◽  
Neonatal Diabetes ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Transient Neonatal Diabetes ◽  
Neonatal Hyperglycaemia

Transient neonatal diabetes and neonatal hyperglycaemia both present in the neonatal period with features of hyperglycaemia, dehydration and weight loss. Differentiating these conditions clinically is difficult. We describe the case of a 13 day old female whom we managed recently who could have had either condition. Hyperglycaemia is not as commonly documented as would be expected for the frequency of neonatal disease and when it does occur, it will worsen neonatal morbidity and mortality. Blood glucose levels in babies ondextrose infusion should be monitored regularly in order to help individualiseglucose requirements.

scholarly journals Sialoblastoma and Hepatoblastoma in an Infant: A Case Report and Review of the Literature

2021 ◽  
Vol 18 (4) ◽  
Author(s):  
Lin Xu ◽  
Yumin Zhong
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Neonatal Period ◽  
Salivary Gland Tumor ◽  
Review Of The Literature ◽  
Gland Tumor ◽  
Pediatric Malignancies

: Sialoblastoma is a rare salivary gland tumor, diagnosed in the neonatal period or during infancy. Hepatoblastoma accounts for less than 1% of all pediatric malignancies. The co-occurrence of these two tumors is extremely uncommon. Here, we report a case of concurrent sialoblastoma and hepatoblastoma in an infant.

Tuberculous brain abscess: A case report with a review of the literature in English

1999 ◽  
Vol 19 (3) ◽  
pp. 328-335
Author(s):  
Shanop Shuangshoti Shuangshoti ◽  
Samruay Shuangshoti
Keyword(s):  
Case Report ◽  
Brain Abscess ◽  
Review Of The Literature ◽  
Tuberculous Brain Abscess

Abstract #1038: Familial Dysalbuminemic Hyperthyroxinemia: A Case Report and Review of the Literature

2015 ◽  
Vol 21 ◽  
pp. 209-210
Author(s):  
Richa Bhattarai ◽  
Bidur Dhakal ◽  
Joseph Belsky ◽  
Nadja Pedersen ◽  
Maria Jan ◽  
...  
Keyword(s):  
Case Report ◽  
Review Of The Literature
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